Relationship of chloroquine-induced redistribution of a neutral aminopeptidase to hemoglobin accumulation in malaria parasites.

abstract：:Cocoa flavonoids are able to reduce cardiovascular risk by improving endothelial function and decreasing blood pressure (BP). Interest in the biological activities of cocoa is daily increasing. A recent meta-analysis shows flavanol-rich cocoa administration decreases mean systolic (-4.5mm Hg; p<0.001) and diastolic (-...

journal_title：Archives of biochemistry and biophysics

authors： Grassi D,Desideri G,Ferri C

更新日期：2010-09-01 00:00:00

abstract：:Glyceraldehyde (GA) has been used to study insulin secretion for decades and it is widely assumed that beta-cell metabolism of GA after its phosphorylation by triokinase is similar to metabolism of glucose; that is metabolism through distal glycolysis and oxidation in mitochondria. New data supported by existing infor...

journal_title：Archives of biochemistry and biophysics

authors： MacDonald MJ,Chaplen FW,Triplett CK,Gong Q,Drought H

更新日期：2006-03-15 00:00:00

abstract：:Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool to investigate the structure and dynamics of RNA, because many biologically important RNAs have conformationally flexible structures, which makes them difficult to crystallize. Functional, independently folded RNA domains, range in size between simple st...

journal_title：Archives of biochemistry and biophysics

authors： Barnwal RP,Yang F,Varani G

更新日期：2017-08-15 00:00:00

abstract：:Human malic enzyme was studied by steady state kinetics, deuterium isotope effects, and 13C isotope effects with both the physiological dinucleotide cofactor and several alternate cofactors. The log V vs pH profile with NAD revealed two pK(a) values too close to be separately determined, but with an average value of 7...

journal_title：Archives of biochemistry and biophysics

authors： Rishavy MA,Yang Z,Tong L,Cleland WW

更新日期：2001-12-01 00:00:00

abstract：:Lipid homeostasis in liver is known to be altered with diabetes mellitus, ultimately leading to liver damage and related complications. The present work aimed to evaluate changes in the liver phospholipid profile after 4 months of uncontrolled hyperglycemia. Twenty Wistar rats were divided into two groups: control and...

journal_title：Archives of biochemistry and biophysics

authors： Simões C,Domingues P,Ferreira R,Amado F,Duarte JA,Vitorino R,Neuparth MJ,Nunes C,Rocha C,Duarte I,Domingues MR

更新日期：2013-10-15 00:00:00

abstract：:The enhancement of the binding of plasma fibronectin to collagen or gelatin by heparin was previously thought to be due primarily to interaction of heparin with fibronectin. We observed, however, that the elution of purified human plasma fibronectin from heparin-treated gelatin-agarose required the same high urea conc...

journal_title：Archives of biochemistry and biophysics

authors： Smith RL,Griffin CA

更新日期：1988-10-01 00:00:00

abstract：:We measured temporal oscillations of intracellular K+ concentration in yeast cells exhibiting glycolytic oscillations using fluorescence spectroscopy and microscopy methods. These oscillations showed the same period as those of glycolytic metabolites (NADH, ATP), indicating a strong coupling between them. We experimen...

journal_title：Archives of biochemistry and biophysics

authors： Olsen LF,Stock RP,Bagatolli LA

更新日期：2020-03-15 00:00:00

abstract：:After an energy source shift-down, Escherichia coli accumulates 70 S ribosome-mRNA complexes ("70 S monosomes"). The monosome mRNA strands are predominantly primary transcription products with purine nucleoside 5'-triphosphate and 5'-diphosphate termini present at a 1:2 ratio. The number-average chain length is 564 +/...

journal_title：Archives of biochemistry and biophysics

authors： Wnek AP,Jacobson LA

更新日期：1985-08-15 00:00:00

abstract：:Mycobactin acylation plays a crucial role in the ability of Mycobacterium tuberculosis to acquire intracellular iron during infection. M. tuberculosis Rv1347c, the lysine N(epsilon)-acyltransferase responsible for mycobactin acylation, represents a valid target for the development of novel anti-tubercular agents. Here...

journal_title：Archives of biochemistry and biophysics

authors： Frankel BA,Blanchard JS

更新日期：2008-09-15 00:00:00

abstract：:The application of 1H-nuclear Overhauser enhancement, 1H-spin-lattice-relaxation-time and 1H-chemical shift measurements for the assessment of the conformational preferences of oligosaccharides are briefly reviewed. It is demonstrated that additivity rules, for the correlation of the chemical shifts of similar hydroge...

journal_title：Archives of biochemistry and biophysics

authors： Lemieux RU,Bock K

更新日期：1983-02-15 00:00:00

abstract：:The portrait of osteoblasts and osteocytes has been subjected to a revision, since a large body of evidence is attributing these cells amazing roles both inside and outside the bone. The osteoblast, long confined to its bone building function, is actually a very eclectic cell, actively regulating osteoclast formation ...

journal_title：Archives of biochemistry and biophysics

authors： Capulli M,Paone R,Rucci N

更新日期：2014-11-01 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are reported to exert beneficial effects in Alzheimer's disease. Some PUFAs are known to reduce amyloid-beta (Aβ) toxicity by promoting its degradation and clearance. Studies on the direct interactions of PUFAs with Aβ peptides are limited and contradictory. In this study, we report...

journal_title：Archives of biochemistry and biophysics

authors： El Shatshat A,Pham AT,Rao PPN

更新日期：2019-03-15 00:00:00

abstract：:Rats were fed toxic levels of methionine with or without simultaneous dietary supplements of glycine and serine. Feed intake, growth rate, and metabolite concentrations in intestine, plasma, liver, skeletal muscle, and kidneys were monitored. Both toxic amounts of methionine and supplemental glycine and serine affecte...

journal_title：Archives of biochemistry and biophysics

authors： Regina M,Korhonen VP,Smith TK,Alakuijala L,Eloranta TO

更新日期：1993-02-01 00:00:00

abstract：:The spinach stromal, thylakoid-bound, and cytosolic ascorbate peroxidase isozymes (EC 1.11.1.11) were overexpressed in Escherichia coli, and their enzymatic properties were compared with the respective native isozymes. The purification of the recombinant stromal and cytosolic ascorbate peroxidases using the convention...

journal_title：Archives of biochemistry and biophysics

authors： Yoshimura K,Ishikawa T,Nakamura Y,Tamoi M,Takeda T,Tada T,Nishimura K,Shigeoka S

更新日期：1998-05-01 00:00:00

abstract：:Chloride ion is found to be an essential factor in photoreactivation of the oxygen-evolving center. Tris-washed, 2,6-dichlorophenol indophenol-treated grana are low in both Mn content and oxygen-evolving activity. These grana can restore high oxygen-evolving activity, however, by incorporating Mn2+ ion under weak ligh...

journal_title：Archives of biochemistry and biophysics

authors： Yamashita T,Ashizawa A

更新日期：1985-05-01 00:00:00

abstract：:Interleukin-1 alpha (IL-1) stimulated the release of degraded proteoglycan from primary cultures of chondrocyte monolayers in a time- and dose-dependent fashion. Bafilomycin A1, a specific inhibitor of the vacuolar H(+)-ATPase, efficiently blocked acidification of the chondrocyte vacuolar system. Under these condition...

journal_title：Archives of biochemistry and biophysics

authors： Yocum SA,Lopresti-Morrow LL,Gabel CA,Milici AJ,Mitchell PG

更新日期：1995-02-01 00:00:00

abstract：:Evidence for the formation of a positional isomer of leukotriene (LT) C3 (8,9-LTC3) from dihomo-gamma-linolenic acid has been published (Hammarström, S. J. Biol. Chem. 256, 7712-7714, 1981). This report describes the conversion of dihomo-gamma-linolenic acid to a postulated intermediate in former reaction, 8,9-LTA3, b...

journal_title：Archives of biochemistry and biophysics

authors： Reddy CC,Bertler C,Hammarström S

更新日期：1990-06-01 00:00:00

abstract：:Progress of mutagenesis studies on the relation of the structure of Na+/K+-ATPase to its reaction mechanism has been impeded by the paucity of information on the properties of small amounts of impure recombinant enzyme obtained in the currently available expression systems, and the uncertainty of whether expression in...

journal_title：Archives of biochemistry and biophysics

authors： Xie Z,Wang Y,Liu G,Zolotarjova N,Periyasamy SM,Askari A

更新日期：1996-06-01 00:00:00

abstract：:Systemic exposure to gram-negative bacterial substances such as lipopolysaccharide (LPS, or endotoxin) induces an uncontrolled, massive inflammatory reaction which culminates in multiple system organ failure and death. Septic shock often does not respond to corticosteroids; however, certain low-molecular-weight antiox...

journal_title：Archives of biochemistry and biophysics

authors： Stewart CA,Hyam K,Wallis G,Sang H,Robinson KA,Floyd RA,Kotake Y,Hensley K

更新日期：1999-05-01 00:00:00

abstract：:Low-molecular-weight (LMW) thiols are a class of highly reactive compounds massively involved in the maintenance of cellular redox homeostasis. They are implicated in plant responses to almost all stress factors, as well as in the regulation of cellular metabolism. The most studied LMW thiols are glutathione and its b...

journal_title：Archives of biochemistry and biophysics

authors： Pivato M,Fabrega-Prats M,Masi A

更新日期：2014-10-15 00:00:00

abstract：:The activities, properties, and steady-state kinetics of the five enzymes catalyzing the synthesis of 1-acyl- and 1-alkyl-sn-glycerol 3-phosphate in the cultured skin fibroblasts from Zellweger syndrome patients and normal controls were studied in detail. Judging from their Km and Vmax values, glycerol phosphate acylt...

journal_title：Archives of biochemistry and biophysics

authors： Webber KO,Datta NS,Hajra AK

更新日期：1987-05-01 00:00:00

abstract：:Peroxynitrite-mediated one-electron oxidations may be an important event in its cytotoxic mechanisms, and yet, free radical formation in the presence of peroxynitrite is difficult to study by EPR-spin trapping because adducts from most spin traps are destroyed by the oxidant. This led to some controversy with regard t...

journal_title：Archives of biochemistry and biophysics

authors： Gatti RM,Alvarez B,Vasquez-Vivar J,Radi R,Augusto O

更新日期：1998-01-01 00:00:00

abstract：:Osmolytes are small organic molecules accumulated by organisms under stress conditions to protect macromolecular structure and function. In the present study, we have investigated the effect of several binary osmolyte mixtures on the protein folding/stability and function of RNase-A. For this, we have measured ΔGD(o) ...

journal_title：Archives of biochemistry and biophysics

authors： Warepam M,Singh LR

更新日期：2015-05-01 00:00:00

abstract：:The amino acid sequences of two very different high-potential iron-sulfur protein (HiPIP) isozymes have been determined from the moderately halophilic purple phototrophic bacterium, Rhodospirillum salinarum. Iso-1 HiPIP, which is monomeric and contains 57 amino acid residues, is most similar to the Thiobacillus ferroo...

journal_title：Archives of biochemistry and biophysics

authors： Ambler RP,Daniel M,Meyer TE,Cusanovich MA

更新日期：1999-09-01 00:00:00

abstract：:Cytochrome P450 (P450) 2D6 is the classic human liver debrisoquine 4-hydroxylase, the first human P450 for which genetic polymorphism was clearly demonstrated. We prepared 11 different constructs of P450 2D6, with modification at the N-terminus, for expression in Escherichia coli with the vector pCW. These varied cons...

journal_title：Archives of biochemistry and biophysics

authors： Gillam EM,Guo Z,Martin MV,Jenkins CM,Guengerich FP

更新日期：1995-06-01 00:00:00

abstract：:Prior exposure of guinea pig macrophages to LPS (lipopolysaccharide) resulted in reduced cAMP-generating responses to prostaglandin E1 and epinephrine. LPS-induced refractoriness was diminished when LPS treatment was carried out in the presence of an inhibitor of prostaglandin synthesis, hydrocortisone, or indomethaci...

journal_title：Archives of biochemistry and biophysics

authors： Hazeki K,Mori Y,Ui M

更新日期：1986-05-01 00:00:00

abstract：:The regulation of expression of hepatic iron-related proteins was examined during iron deficiency caused by scurvy in guinea pigs. Previous studies showed that some effects of scurvy, such as suppression of collagen gene expression, result from events associated with weight loss. During the initial phase of scurvy whe...

journal_title：Archives of biochemistry and biophysics

authors： Gosiewska A,Mahmoodian F,Peterkofsky B

更新日期：1996-01-15 00:00:00

abstract：:Soybean Bowman-Birk protease inhibitor (BBI) is an inhibitor of serine proteases with two functional inhibitory domains of different specificities: one is specific for chymotrypsin-like proteases, the other for trypsin-like proteases. Chymase and tryptase are serine proteases which are stored in mast cell granules and...

journal_title：Archives of biochemistry and biophysics

authors： Ware JH,Wan XS,Rubin H,Schechter NM,Kennedy AR

更新日期：1997-08-01 00:00:00

abstract：:Reperfusion of ischemic myocardial tissue results in an increase in mitochondrial free radical production and declines in respiratory activity. The effects of ischemia and reperfusion on the activities of Krebs cycle enzymes, as well as enzymes involved in electron transport, were evaluated to provide insight into whe...

journal_title：Archives of biochemistry and biophysics

authors： Sadek HA,Humphries KM,Szweda PA,Szweda LI

更新日期：2002-10-15 00:00:00

abstract：:Nitroxides stable radicals are unreactive toward most diamagnetic molecules, but readily undergo one-electron redox reactions with paramagnetic species such as free radicals and transition metals, thus serving as cell-permeable antioxidants. The cytotoxicity of juglone (5-hydroxy-1,4-naphthoquinone), like that of othe...

journal_title：Archives of biochemistry and biophysics

authors： Zhang R,Hirsch O,Mohsen M,Samuni A

更新日期：1994-08-01 00:00:00