Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sensitive and multidrug-resistant tumor cells.

abstract：BACKGROUND:Locally recurrent rate of advanced head and neck squamous cell carcinoma (HNSCC) still remains high and the treatment is controversial. PATIENTS AND METHODS:We retrospectively analyzed ninety-three patients with recurrent advanced oral cancer from 2009 to 2013. Sixty-four patients are in the docetaxel with ...

journal_title：Anticancer research

authors： Yang WC,Chen CH,Tang JY,Wu CF,Liu YC,Sun Y,Lin SF

更新日期：2014-07-01 00:00:00

abstract：:Apoptotic cell death, in conjunction with mitosis, plays an important role in maintaining tissue homeostasis. Many cancer treatment modalities have been shown to induce apoptosis in sensitive cells. The purpose of this study was to determine the amount of apoptosis in-situ, the expression of apoptosis related genes p5...

journal_title：Anticancer research

authors： Pulkkinen JO,Klemi P,Martikainen P,Grénman R

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:It was recently reported that expression of prospero homeobox protein-1 (PROX1) is correlated with the prognosis of esophageal cancer and colorectal cancer. However, its correlation with gastric cancer is unclear. MATERIALS AND METHODS:Our study analyzed the effect of PROX1 knockdown on the migration, invas...

journal_title：Anticancer research

authors： Ueta K,Otowa Y,Kakeji Y,Hirashima M

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND/AIM:The amino acid positron emission tomography (PET) tracer [(18)F]-3-fluoro-alpha-methyltyrosine ((18)F-FAMT) is known to be highly specific for malignancies. We evaluated the accumulation of (18)F-FDG or (18)F-FAMT in lymph nodes (LN) prior to definitive chemoradiotherapy (CRT) for esophageal cancer. PAT...

journal_title：Anticancer research

authors： Sohda M,Miyazaki T,Honjyo H,Hara K,Ozawa D,Suzuki S,Tanaka N,Sano A,Sakai M,Yokobori T,Nakajima M,Fukuchi M,Kato H,Higuchi T,Tsushima Y,Kuwano H

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND/AIM:The mechanism responsible for B-cell translocation gene 1 (BTG1) down-regulation in breast carcinoma remains unknown. We examined the BTG1 expression status in breast carcinoma cells and investigated the mechanism underlying the observed alterations. MATERIALS AND METHODS:Four breast carcinoma cell line...

journal_title：Anticancer research

authors： Woo HY,DO SI,Kim SH,Song SY,Kim HS

更新日期：2019-10-01 00:00:00

abstract：AIM:To evaluate the role of radiotherapy alone or combined with chemotherapy in the treatment of recurrent vulvar cancer, emphasising the prognostic factors and outcomes. MATERIALS AND METHODS:Twenty women with loco-regional recurrence of vulvar carcinoma were retrospectively reviewed. Eleven patients were managed wit...

journal_title：Anticancer research

authors： Raffetto N,Tombolini V,Santarelli M,Valeriani M,Galla DA,Enrici RM

更新日期：2003-05-01 00:00:00

abstract：:A pilot study to evaluate the predictive value of Indium-111-labelled somatostatin analogue [DTPA-D-Phe1]-octreotide scintigraphy (OctreoScan111) in the Octreotide treatment of hormone-refractory prostatic adenocarcinoma was initiated. Ten patients were investigated with OctreoScan111 with regard to disease extension ...

journal_title：Anticancer research

authors： Kälkner KM,Nilsson S,Westlin JE

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIM:Cabazitaxel is an approved second-line treatment for docetaxel-refractory metastatic castration-resistant prostate cancer. However, the median time to progression on cabazitaxel is 2.8 months. We aimed to determine whether DNA methylation plays a role in cabazitaxel resistance. MATERIALS AND METHODS:DU1...

journal_title：Anticancer research

authors： Ramachandran K,Speer C,Nathanson L,Claros M,Singal R

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:PAR-1 has been involved in inflammation of the gastrointestinal tract, tumour cell growth and invasion of gastric carcinoma cells. Thus, we aimed at determining, for the first time, the association between PAR-1 - 506 ins/del and -IVSn-14 A/T and risk of Helicobacter pylori-related gastric cancer (GC) in an ...

journal_title：Anticancer research

authors： Castaño-Rodríguez N,Kaakoush NO,Goh KL,Fock KM,Chionh YT,Sutton P,Mitchell HM

更新日期：2012-09-01 00:00:00

abstract：:Human epidemiological studies suggest an association between N-acetyltransferase (NAT) activity and the incidence of bladder and colorectal cancers. In this study, paclitaxel was selected to examine the inhibition of arylamine NAT activity, gene expression and 2-aminofluorene-DNA adduct formation in a human osteogenic...

journal_title：Anticancer research

authors： Lu KH,Wang DY,Lue KH,Hsiao YM,Chou MC,Chen YS,Chung JG

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Concurrent chemoradiotherapy (CCRT) is used to treat advanced head and neck cancer. The accuracy of evaluating lymph nodes metastases following CCRT is important for subsequent therapy. PATIENTS AND METHODS:Patients were divided into two groups, the complete response (CR) and the non-CR groups, as determine...

journal_title：Anticancer research

authors： Nishimura G,Matsuda H,Taguchi T,Takahashi M,Komatsu M,Sano D,Sakuma N,Arai Y,Takahashi H

更新日期：2012-02-01 00:00:00

abstract：:Human papillomavirus (HPV)-positive tonsillar- and base of tongue cancer is increasing epidemically and has much better outcome than corresponding HPV-negative cancer and most other head and neck cancers with around 80% 3-year disease free survival with conventional radiotherapy and surgery. Consequently, most HPV-pos...

journal_title：Anticancer research

authors： Näsman A,Bersani C,Lindquist D,Du J,Ramqvist T,Dalianis T

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Intraosseous lipoma remains a poorly-characterized tumor. In paticular, the natural course of intracalcaneus lipoma after conservative treatment and the appropriate surgical modalities are still quite controversial. PATIENTS AND METHODS:We reviewed six symptomatic patients who underwent curettage of intraca...

journal_title：Anticancer research

authors： Muramatsu K,Tominaga Y,Hashimoto T,Taguchi T

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway is critical in inflammation, proliferation and carcinogenesis. There exist three main players in this pathway. The inhibitor of NF-κB (IκB), IκB kinase (IκK)- NF-κB essential modulator (NEMO) complex and NF-κB. The IkK-NEMO co...

journal_title：Anticancer research

authors： Kadioglu O,Nass J,Saeed ME,Schuler B,Efferth T

更新日期：2015-05-01 00:00:00

abstract：:The belief that n-3 polyunsaturated fatty acids are in general cytotoxic to tumor cells appears not to be accurate. Of four tumor cell lines exposed to 35 microM docosahexaenoic acid (DHA, 22:6 n-3), we found only one (A-427, lung carcinoma) to be sensitive, whereas three (A-172, A549 and SK-LU-1) in fact were stimula...

journal_title：Anticancer research

authors： Schønberg SA,Skorpen F

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:It is of great clinical concern to preoperatively predict the need for blood transfusions during hepatectomy for hepatocellular carcinoma (HCC). PATIENTS AND METHODS:A total of 168 consecutive patients undergoing elective hepatectomy for HCC were retrospectively reviewed. We investigated preoperative factor...

journal_title：Anticancer research

authors： Yamamoto Y,Ikoma H,Morimura R,Konishi H,Murayama Y,Komatsu S,Shiozaki A,Kuriu Y,Kubota T,Nakanishi M,Ichikawa D,Fujiwara H,Okamoto K,Sakakura C,Ochiai T,Otsuji E

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The role of combination chemotherapy regimens in the management of ovarian cancer patients with tumors previously exposed to platinum compounds and paclitaxel has not yet been defined. The present phase II study evaluated the activity and toxicity of a paclitaxel-ifosfamide-cisplatin combination in the afore...

journal_title：Anticancer research

authors： Polyzos A,Kosmas C,Tsavaris N,Toufexi H,Lagadas A,Gogas H,Giannakopoulos K,Kouraklis G,Griniatsos J,Felekouras E,Tsigris C,Nikiteas N,Papadopoulos O,Giannopoulos A

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Laparoscopic pelvic lymph node staging is widely used in patients with cervical cancer prior to the initiation of primary chemoradiation therapy. Data on the morbidity of this procedure are sparse. PATIENTS AND METHODS:Between 1995 and 2007, 71 patients with locally advanced cervical cancer (FIGO stage IB2-...

journal_title：Anticancer research

authors： Polterauer S,Hefler LA,Petry M,Seebacher V,Tempfer C,Reinthaller A

更新日期：2008-05-01 00:00:00

abstract：:Vitamin D is a steroid hormone traditionally recognized for maintaining calcium and phosphorous homeostasis in the body. However, it is now widely accepted that it exerts several extraskeletal actions, including anti-tumorigenic and immunomodulatory effects in vitro and in vivo. There is now a huge interest in studyin...

journal_title：Anticancer research

authors： Norton R,O'Connell MA

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Our purpose was to determine the effects of amifostine, a cytoprotective agent, on doxorubicin tolerance and cardiotoxicity in rats. MATERIALS AND METHODS:Male Wistar rats were treated every other day with an intraperitoneal injection of amifostine or saline 30 minutes before intraperitoneal injection of do...

journal_title：Anticancer research

authors： Nazeyrollas P,Frances C,Prevost A,Costa B,Lorenzato M,Kantelip JP,Elaerts J,Millart H

更新日期：2003-01-01 00:00:00

abstract：:2-4 Dinitrochlorobenzene (D.N.C.B.) is a synthetic primary allergenic molecule which has proved to have at least two useful clinical applications as regards neoplastic conditions. As a diagnostic measure, it serves in the detection of global alterations of cellular immunity. As a therapeutical measure, its epicutaneou...

journal_title：Anticancer research

authors： Truchetet F,Heid E,Friedel J,Chartier C,Grosshans E

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Patients with advanced pancreatic carcinoma have a risk of relapse after primary therapy, and the prognosis for these patients remains bleak. The effect of immuno-cell therapy in advanced pancreatic carcinoma, with or without other standard therapies, was examined. PATIENTS AND METHODS:Forty-six patients wi...

journal_title：Anticancer research

authors： Kaneko T,Goto S,Kato A,Akeyama A,Tomonaga M,Fujimoto K,Miyamoto Y,Eriguchi M,Egawa K

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIM:The main objective of the present study was to evaluate the significance of apoptosis in the Fletcher's risk classification for gastrointestinal stromal tumors (GISTs). MATERIALS AND METHODS:Apoptotic cells were identified by immunostaining for single-stranded DNA (ssDNA). We assigned each GIST to one o...

journal_title：Anticancer research

authors： Mochizuki K,Kondo T,Oishi N,Tahara I,Inoue T,Kasai K,Nakazawa T,Katoh R

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Despite the key role of mutational analysis in targeted therapy, the difficulty in acquisition of adequate tumor tissues for molecular genotyping in advanced non-small cell lung cancer (NSCLC) has led to the need for a fast and efficient method for detecting genetic alterations for targeted therapy. PATIENT...

journal_title：Anticancer research

authors： Maeng CH,Lee HY,Kim YW,Choi MK,Hong JY,Jung HA,Lee KS,Kim H,Kwon OJ,Sun JM,Ahn JS,Park K,Um SW,Ahn MJ

更新日期：2013-11-01 00:00:00

abstract：:The effects of silybinin, an antioxidant, on the pharmacokinetics of tamoxifen and its metabolite, 4-hydroxytamoxifen, were investigated in rats. A single dose of tamoxifen was administered intravenously (2 mg/kg) and orally (10 mg/kg) without or with silybinin (0.5, 2.5 and 10 mg/kg) to rats. Silybinin significantly ...

journal_title：Anticancer research

authors： Kim CS,Choi SJ,Park CY,Li C,Choi JS

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIM:To investigate the impact of inguinal lymph node dissection (ILND) following neoadjuvant chemoradiotherapy (NACRT) for rectal cancer patients with ILN metastasis. PATIENTS AND METHODS:Forty-three patients with rectal cancer underwent NACRT followed by curative surgery between January 2005 and December 2...

journal_title：Anticancer research

authors： Ueta K,Matsuda T,Yamashita K,Hasegawa H,Mukohyama J,Yamamoto M,Matsuda Y,Kanaji S,Oshikiri T,Nakamura T,Suzuki S,Kakeji Y

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) are important regulators of cancer invasion and metastasis. Their associations to high-risk (HR) human papillomavirus (HPV) in cervical intra-epithelial neoplasia (CIN) and cervical cancer (CC) are unexplored and their prognostic significanc...

journal_title：Anticancer research

authors： Branca M,Ciotti M,Giorgi C,Santini D,Di Bonito L,Costa S,Benedetto A,Bonifacio D,Di Bonito P,Paba P,Accardi L,Syrjänen S,Favalli C,Syrjänen K,HPV-PathogenISS Study Group.

更新日期：2006-03-01 00:00:00

abstract：:We examined the expression of survivin using immunohistochemistry in 102 cases of laryngeal squamous cell carcinoma (LSCC). Overall, 65.7% (67 out of 102) of tumors were positive for survivin expression and significantly associated with tumor site, poor differentiation, tumor size, lymph node metastasis and advanced s...

journal_title：Anticancer research

authors： Dong Y,Sui L,Watanabe Y,Sugimoto K,Tokuda M

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:In vitro studies have indicated that epidermal growth factor receptor (EGFR) may intensify signaling output by the receptor's overexpression, heterodimerization with HER-2, or autocrine expression of ligands. The purpose of the present study was to evaluate the correlation between EGFR and its related protei...

journal_title：Anticancer research

authors： Mukohara T,Kudoh S,Matsuura K,Yamauchi S,Kimura T,Yoshimura N,Kanazawa H,Hirata K,Inoue K,Wanibuchi H,Fukushima S,Yoshikawa J

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Randomized controlled trials had demonstrated local therapy, such as radiotherapy, can improve outcomes of patients with lung cancer with oligometastatic disease (OMD). However, the definition of OMD is not uniform and the European Society for Radiotherapy and Oncology (ESTRO) and European Organisation for R...

journal_title：Anticancer research

authors： Chen HJ,Tu CY,Hsia TC,Fang HY,Chen CH,Chen SC,Li CH,Liao YM,Hsieh CY,Lein MY,Liang JA,Chien CR

更新日期：2020-10-01 00:00:00