Abstract：
:Demonstration of amyloid deposits in biopsy specimens is the only means of confirming the diagnosis of amyloidosis. In experienced hands, nonsurgical biopsies of the rectal mucosa or, preferably, of the abdominal fat pad or labial salivary glands provide the diagnosis in 80 to 85% of cases. Immunolabeling studies help to determine the histological type of amyloidosis but are not performed routinely in everyday practice. In patients with a family history of amyloidosis, studies of the genome and amyloid protein can identify the protein variants capable of causing systemic amyloidosis. Once the diagnosis of amyloidosis is established, the extent of systemic involvement with amyloid should be evaluated by performing renal and hepatic function tests, a proteinuria assay, and an echocardiogram. Scintigraphy with radiolabeled serum amyloid P (SAP) component is a rapid and specific investigation that provides a map of the amyloid deposits. Deposits are usually seen in the liver and spleen. SAP component scintigraphy can provide support for the diagnosis of amyloidosis in patients with negative histological studies. Tissue retention of radioactivity predicts survival.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Hachulla E,Grateau Gdoi
10.1016/s1297-319x(02)00449-9subject
Has Abstractpub_date
2002-12-01 00:00:00pages
538-45issue
6eissn
1297-319Xissn
1778-7254pii
S1297319X02004499journal_volume
69pub_type
杂志文章,评审相关文献
JOINT BONE SPINE文献大全abstract：BACKGROUND:Although the cause of adolescent idiopathic scoliosis remains unclear, pinealectomy is followed by the development of scoliosis in chickens. Melatonin is the only hormone secreted by pineal gland. OBJECTIVE:To assess serum melatonin levels in adolescents with idiopathic scoliosis. METHODS:Serum melatonin w...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:We report a case of a culture-negative osteomyelitis in which our newly developed real-time polymerase chain reaction (PCR) could differentiate Staphylococcus aureus from Staphylococcus epidermidis. This is the first report that described the application of this novel assay to an orthopedics clinical sample. This assa...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2005.11.014
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVES:To study and compare the clinical and serological features of patients with elderly versus adult and younger onset of primary Sjögren's syndrome (pSS). METHODS:We analyzed retrospectively 336 consecutive pSS patients followed at our unit. They were subdivided into three groups according to the age at diseas...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2010.05.008
更新日期：2011-03-01 00:00:00
abstract：:We present a case of giant chronic expanding hematoma occurring in the left lateral thigh without any history of trauma or chronic medical disease. In our case, a diagnosis was unable to perform through conventional diagnosis method, which was confirmed by histopathological examination after successful surgical treatm...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2007.01.041
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:To assess if the use of biological marker of bone resorption (CTX) feedback is a mean to improve persistence on monthly oral ibandronate. METHODS:One year prospective multicenter study using a cluster randomisation design with physicians as randomized units into two groups, A and B; in group B, physicians us...
journal_title：Joint bone spine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jbspin.2011.05.001
更新日期：2012-07-01 00:00:00
abstract：:Nitric oxide (NO) is attracting considerable interest because it mediates many functions. This gas is ubiquitously produced in the body by three enzymes, called NO synthases. Two NO synthases are constitutively expressed, one in the nervous system and the other in the blood vessels, where it regulates tissue perfusion...
journal_title：Joint bone spine
pub_type： 社论,评审
doi：10.1016/s1297-319x(01)00308-6
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVES:Despite the efficacy of TNF inhibitors, most patients with psoriatic arthritis maintain a residual synovial inflammation. The main aim of the study was to evaluate the effects of mud-bath therapy on clinical picture of PsA patients treated with TNF inhibitors. The secondary outcome was to assess synovial inf...
journal_title：Joint bone spine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jbspin.2014.11.002
更新日期：2015-03-01 00:00:00
abstract：:Osteoarthritis is a major public health burden. The incidence of osteoarthritis increases with advancing age. Symptomatic treatments aimed at alleviating the pain and thereby restoring joint function form the basis of the treatment. The chronic course requires long-term treatment with special attention to minimizing t...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2003.09.010
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVES:To describe the care trajectories of adults aged ≥50 years with fragility fractures in France. METHODS:A postal questionnaire was sent to 15,000 individuals aged ≥50 years extracted from a representative panel of the French population (METASKOPE) in April-May 2018. Respondents experiencing a single fragilit...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2020.04.007
更新日期：2020-10-01 00:00:00
abstract：:Androgen-deprivation therapy (ADT) in patients with prostate cancer can be achieved surgically or chemically, notably by prescribing LHRH analogs. Major bone loss occurs rapidly in both cases, due to the decrease in testosterone levels, and can increase the fracture risk. The objective of developing these recommendati...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2018.09.017
更新日期：2019-01-01 00:00:00
abstract：:Macrophage activation syndrome (MAS) is a rare and serious complication of adult-onset Still's disease. We describe a case in a 49-year-old woman with Still's disease refractory to glucocorticoids, methotrexate, and infliximab. Anakinra provided satisfactory disease control for 1 year, after which escape phenomenon oc...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2013.04.011
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVE:To determine in real-life conditions the safety of treatment with rituximab (RTX) in patients with rheumatoid arthritis (RA) regarding malignancies. METHODS:Analysis of safety data from a cohort of RA patients who received at least one course of RTX. RA patients with previous malignancies were followed-up an...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2010.11.012
更新日期：2011-10-01 00:00:00
abstract：:Clinical data suggested that parathyroid hormone (PTH) might be effective in improving bone mass in patients with osteoporosis, providing its resorptive effects, which are particularly marked at cortical sites, were kept under control. We reviewed the evidence that intermittent PTH therapy is a valid treatment option ...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2005.11.007
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVES:The aims of this study in SLE population were (1) to describe ultrasonography (US) joint abnormalities, (2) to estimate the reliability of clinical swollen joint count (C-SJC) and SLEDAI (C-SLEDAI) versus US-SJC and US-SLEDAI scores, (3) to highlight specific patterns of lupus patients with Power Doppler (PD...
journal_title：Joint bone spine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jbspin.2018.01.013
更新日期：2018-12-01 00:00:00
abstract：UNLABELLED:The management of spondyloarthritis is challenging and has changed with the development of new concepts and treatments. OBJECTIVE:To develop practice guidelines for the everyday management of patients with spondyloarthritis (including psoriatic arthritis), by updating previous national and international rec...
journal_title：Joint bone spine
pub_type： 杂志文章,实务指引
doi：10.1016/j.jbspin.2013.12.002
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To investigate plasma and synovial fluid (SF) periostin of knee osteoarthritis (OA) patients and to determine the relationship between periostin levels and the radiographic severity. METHODS:A total of 110 subjects (90 knee OA patients and 20 healthy controls) were enrolled in this study. Plasma and SF perio...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2015.01.023
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:To determine the very long-term clinical and functional outcomes in rheumatoid arthritis (RA) patients followed by office-based or hospital-based physicians. PATIENTS AND METHODS:A questionnaire including items on clinical outcomes (active disease, remission, burn-out) and the Health Assessment Questionnaire...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/s1297-319x(02)00370-6
更新日期：2002-03-01 00:00:00
abstract：:The objective of this article is to review data on joint distraction used to treat knee osteoarthritis. Joint distraction is a surgical procedure in which the two bony ends of the joint are gradually pulled apart then kept separated for 2 months in an external fixation frame. Weight bearing is continued to ensure vari...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2016.03.004
更新日期：2017-03-01 00:00:00
abstract：:Disseminated extrapulmonary tuberculosis is uncommon, particularly among immunocompentent individuals. We report the case of a 38-year-old woman from the Ivory Coast who had osteomyelitis in the right humerus, a cold abscess in the pectoralis major muscle, T11 spondylitis, deep lymphadenopathies, peritoneal nodules, a...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2004.05.005
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVES:Some immunological abnormalities have been described in seronegative spondyloarthropathies (SpA). The aim of this study is to determine the serum levels of IL-1beta, TNF-alpha and IL-8, which are proinflammatory cytokines in active and inactive patients with SpA, to compare the results with those of controls...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/s1297-319x(02)00431-1
更新日期：2002-10-01 00:00:00
abstract：:Giant cell arteritis (GCA) affects middle-sized or large arteries in individuals over 50 years of age. GCA is characterized by a combination of focal inflammation responsible for arterial stenosis or occlusion and of systemic inflammation manifesting as polymyalgia rheumatica, a decline in general health, and inflamma...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2011.09.015
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVE:To investigate the cutaneous tolerance of febuxostat in gouty patients with skin intolerance to allopurinol. METHODS:We identified all gouty patients who had sequentially received allopurinol and febuxostat in the rheumatology departments of 4 university hospitals in France and collected data from hospital f...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2015.07.011
更新日期：2016-05-01 00:00:00
abstract：:Canakinumab is indicated for patients with frequent gouty arthritis attacks who cannot be managed with standard-of-care medication, and should be used according to the labeled indication. Given its mechanism of action, physicians need to be aware of the potential contraindications and precautions with its use. When de...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/S1297-319X(15)30005-1
更新日期：2015-10-01 00:00:00
abstract：:Although fractures involving the wrist, spine, and proximal femur are known to be strongly associated with osteoporosis, the underlying bone insufficiency often receives insufficient diagnostic and therapeutic attention. Osteoporosis also increases the risk of fractures at other sites. Low-energy fractures in patients...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2004.04.002
更新日期：2005-10-01 00:00:00
abstract：:Musculoskeletal symptoms are not infrequent in leprosy and, when inaugural, may be difficult to differentiate from other conditions, most notably rheumatoid arthritis. We report the case of a 24 year-old man with a 5 year history of intermittent inflammatory arthritis and fever. Physical findings and radiographs were ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2005.03.014
更新日期：2006-05-01 00:00:00
abstract：:Stickler syndrome is a group of rare genetic conditions (incidence, 1/7500 births) related to mutations in the collagen genes. Both the mutations and the clinical features vary widely across affected patients. The main manifestations are craniofacial birth defects, bone and joint symptoms, ocular abnormalities, and he...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2010.03.012
更新日期：2011-01-01 00:00:00
abstract：:Cystic fibrosis (CF) is the most common autosomal recessive disease among Caucasians. It is due to a mutation in the cftr gene, which encodes the CF transmembrane conductance regulator (CFTR), a chloride channel located in the plasma membrane of mucus-secreting epithelial cells. Numerous other functions of the CFTR pr...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2010.11.015
更新日期：2011-10-01 00:00:00
abstract：:We report the use of intra-articular Botulinum toxin A in two RA patients with persistently painful monoarthritis in ankle/feet joints. Both patients had monarticular pain despite a good response of all other joints to a combination therapy that included anti-tumor necrosis factor therapy. Both patients had failed int...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2008.05.006
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:To assess 5-year treatment responses and TGFB1 gene abnormalities in five patients with ribbing disease. METHODS:PCR analysis and bidirectional sequencing of TGFβ1 exons 1 through 7 were performed in all five patients. RESULTS:The five patients, four women and one man with a mean age of 34 years at symptom ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2013.01.007
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVES:Anti-citrullinated protein/peptide antibodies (ACPA) represent an important tool for the diagnosis of rheumatoid arthritis (RA) and the presence of multiple ACPA specificities is highly correlated with the evolution towards RA. However, little is known about the association of single specificities with disea...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2017.07.009
更新日期：2018-07-01 00:00:00
