Abstract：
:Nitric oxide (NO) is attracting considerable interest because it mediates many functions. This gas is ubiquitously produced in the body by three enzymes, called NO synthases. Two NO synthases are constitutively expressed, one in the nervous system and the other in the blood vessels, where it regulates tissue perfusion. The third NO synthase can be induced by several stimuli (bacterial endotoxins, cytokines), most notably in inflammatory cells and chondrocytes. The effects of NO produced by the inducible NO synthase range from T-cell response modulation to formation of free radicals responsible fortissue damage and cartilage matrix degradation. Administration of NO synthase inhibitors in animal models of arthritis yields ambiguous effects, often with prevention of arthritis, but sometimes with worsening of established arthritis. The data available to date do not support the use of such inhibitors in the treatment of human arthritis.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Bernardeau C,Dernis-Labous E,Blanchard H,Lamarque D,Breban Mdoi
10.1016/s1297-319x(01)00308-6subject
Has Abstractpub_date
2001-12-01 00:00:00pages
457-62issue
6eissn
1297-319Xissn
1778-7254journal_volume
68pub_type
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