Histone deacetylase inhibitors: new treatment options for inflammatory joint disease?

Abstract:

:Histone deacetylase inhibitors (HDIs) are a new class of compounds that are being developed for the treatment of malignancies such as cutaneous T-cell lymphoma. HDIs inhibit the removal of acetyl groups from histones. The histone acetylation process is dependent on two enzymes, histone acetyl transferase (HAT) and histone deacetylase (HDAC), and regulates the expression of genes, including those encoding cell survival or apoptosis. In addition to regulating cell growth, HDIs exert anti-inflammatory effects by controlling the production of anti-inflammatory cytokines; modulating the function of cells such as T cells, monocytes-macrophages, chondrocytes, and osteoclasts; and modulating angiogenesis. In several animal models of arthritis, HDIs improve the clinical manifestations and prevent damage to the bone and cartilage. In humans, the only relevant data available so far come from studies of HAT and HDAC expression in the synovial membrane of patients with rheumatoid arthritis. HDIs may hold promise for the treatment of inflammatory joint disease.

journal_name

Joint Bone Spine

journal_title

Joint bone spine

authors

Toussirot E,Khan KA,Bertolini E,Wendling D,Herbein G

doi

10.1016/j.jbspin.2010.03.009

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

395-8

issue

5

eissn

1297-319X

issn

1778-7254

pii

S1297-319X(10)00067-9

journal_volume

77

pub_type

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