Abstract:
:Histone deacetylase inhibitors (HDIs) are a new class of compounds that are being developed for the treatment of malignancies such as cutaneous T-cell lymphoma. HDIs inhibit the removal of acetyl groups from histones. The histone acetylation process is dependent on two enzymes, histone acetyl transferase (HAT) and histone deacetylase (HDAC), and regulates the expression of genes, including those encoding cell survival or apoptosis. In addition to regulating cell growth, HDIs exert anti-inflammatory effects by controlling the production of anti-inflammatory cytokines; modulating the function of cells such as T cells, monocytes-macrophages, chondrocytes, and osteoclasts; and modulating angiogenesis. In several animal models of arthritis, HDIs improve the clinical manifestations and prevent damage to the bone and cartilage. In humans, the only relevant data available so far come from studies of HAT and HDAC expression in the synovial membrane of patients with rheumatoid arthritis. HDIs may hold promise for the treatment of inflammatory joint disease.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Toussirot E,Khan KA,Bertolini E,Wendling D,Herbein Gdoi
10.1016/j.jbspin.2010.03.009subject
Has Abstractpub_date
2010-10-01 00:00:00pages
395-8issue
5eissn
1297-319Xissn
1778-7254pii
S1297-319X(10)00067-9journal_volume
77pub_type
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