Abstract：
:We describe a patient in whom sporadic Creutzfeldt-Jakob disease (sCJD) occurred one year after the onset of etanercept therapy for rheumatoid arthritis (RA). This association could be a chance occurrence. However, TNF-alpha has been implicated in the pathogenesis of neurodegeneration in sCJD and etanercept might worsen the disease. Such an aggravation has been observed in multiple sclerosis, in which TNF-alpha is the key mediator of demyelination. It may be of interest studying the impact of treatment with TNF-alpha antagonists on prevalence and incidence of those neurodegenerative diseases involving TNF-alpha mediation, such as Alzheimer disease.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Soubrier M,Haïk S,Hauw JJ,Corvol JC,Lyon-Caen O,Dougados Mdoi
10.1016/j.jbspin.2009.05.016subject
Has Abstractpub_date
2010-03-01 00:00:00pages
174-5issue
2eissn
1297-319Xissn
1778-7254pii
S1297-319X(09)00246-2journal_volume
77pub_type
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