Abstract：
BACKGROUND:Although the cause of adolescent idiopathic scoliosis remains unclear, pinealectomy is followed by the development of scoliosis in chickens. Melatonin is the only hormone secreted by pineal gland. OBJECTIVE:To assess serum melatonin levels in adolescents with idiopathic scoliosis. METHODS:Serum melatonin was assayed once, at 12:00 hours, in each of 20 adolescents with idiopathic scoliosis and 10 age-matched siblings. In the patient group, mean age was 14.3 years and the mean Cobb angle was 54.5 degrees (range, 20 degrees-110 degrees). Mean age in the control group was 14 years. RESULTS:Serum melatonin was significantly lower in the patients (mean, 7.7 pg/mL; range, 4 to 13 pg/mL) than in the controls (mean, 29.9 pg/mL; range, 19.3 to 46 pg/mL) (P < 0.00001). The 12 surgically treated patients had a mean melatonin level of 8.1 pg/mL, versus 7.2 pg/mL in the eight other patients (nonsignificant P and regression coefficient values). Serum melatonin was not significantly correlated with the Cobb's angle (regression coefficient, 0.18; P < 0.44). CONCLUSION:Our data suggest that serum melatonin levels may contribute to the pathogenesis of idiopathic scoliosis.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Sadat-Ali M,al-Habdan I,al-Othman Asubject
Has Abstractpub_date
2000-01-01 00:00:00pages
62-4issue
1eissn
1297-319Xissn
1778-7254journal_volume
67pub_type
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