Abstract：
OBJECTIVE:To investigate plasma and synovial fluid (SF) periostin of knee osteoarthritis (OA) patients and to determine the relationship between periostin levels and the radiographic severity. METHODS:A total of 110 subjects (90 knee OA patients and 20 healthy controls) were enrolled in this study. Plasma and SF periostin were examined using an enzyme-linked immunosorbent assay. OA grading was performed using the Kellgren-Lawrence classification. RESULTS:Although plasma periostin was greater in OA patients than in controls, the difference was not significant. Additionally, SF periostin was significantly higher with respect to paired plasma (P<0.001). Moreover, plasma and SF periostin demonstrated significantly positive correlation with the radiographic severity of knee OA (r=0.537, P<0.001 and r=0.427, P<0.001, respectively). Subsequent analysis revealed that there was a positive correlation between plasma and SF periostin (r=0.368, P<0.001). CONCLUSIONS:Plasma and SF periostin levels were positively correlated with the radiographic severity of knee OA.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Honsawek S,Wilairatana V,Udomsinprasert W,Sinlapavilawan P,Jirathanathornnukul Ndoi
10.1016/j.jbspin.2015.01.023subject
Has Abstractpub_date
2015-10-01 00:00:00pages
352-5issue
5eissn
1297-319Xissn
1778-7254pii
S1297-319X(15)00041-Xjournal_volume
82pub_type
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