Systemic sclerosis and gastric MALT lymphoma.

Abstract:

CASE-REPORT:A 76-year-old woman was admitted for evaluation of esophagitis complicating limited cutaneous systemic sclerosis. Endoscopy showed persistent grade III esophagitis and an erythematous antral lesion found upon biopsy to be a lymphoma of mucosa-associated lymphoid tissue (MALT). Tests were positive for Helicobacter pylori. Moderate mucosal infiltration by endoscopic ultrasonography was the only finding from staging investigations. Six months after treatment to eradicate H. pylori, a repeat endoscopy showed no evidence of the lesion. DISCUSSION:MALT lymphomas are usually confined to the gastric wall. Gastric MALT lymphomas have a well-established association with H. pylori infection. The clinical manifestations are nonspecific. Endoscopy usually shows a focus of erythema or, less often, erosion. The diagnosis rests on histological examination of a biopsy, which shows infiltration by monoclonal cells whose immunophenotype is characteristic of marginal-zone B cells. Eradication of H. pylori is the mainstay of treatment.

journal_name

Joint Bone Spine

journal_title

Joint bone spine

authors

Arnaud L,Chryssostalis A,Terris B,Pavy S,Chaussade S,Kahan A,Allanore Y

doi

10.1016/j.jbspin.2005.01.009

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

105-8

issue

1

eissn

1297-319X

issn

1778-7254

pii

S1297-319X(05)00074-6

journal_volume

73

pub_type

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