Abstract：
:Retinoids are effective and widely prescribed in the treatment of severe acne. However their use can be associated with numerous side effects. Some rare cases of premature epiphyseal closure were reported. We present the case of a sixteen-year-old soccer player referred for progressive anterior pain in both knees, evoking a patellar problem. Careful pharmacological questioning revealed use of isotretinoin for several months. MRI findings showed an irregularity of the growth plate and an important metaphyso-epiphyseal oedema, more noticeable in the left knee. Retinoid-induced premature epiphyseal closure was diagnosed. The treatment was stopped, with a resolution of pain within two months. After recovery a persisting small sequelar thumbprint-like growth plate lesion was observed on the control MRI. Retinoids induce an invasion of the growth plate by osteoclasts and a decrease in proteoglycans synthesis. It seems that the knee is the most affected joint. This complication being rare, a radiological follow-up of the young patients treated by retinoids is not proposed.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Luthi F,Eggel Y,Theumann Ndoi
10.1016/j.jbspin.2011.11.001subject
Has Abstractpub_date
2012-05-01 00:00:00pages
314-6issue
3eissn
1297-319Xissn
1778-7254pii
S1297-319X(11)00273-9journal_volume
79pub_type
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