Abstract：
OBJECTIVE:To explore acceptance and retention rate of biosimilar CT-P13 after switching from originator infliximab (OI) in patients with various rheumatic diseases. METHODS:Patients with stable rheumatoid arthritis (RA), ankylosing spondylitis (AS) or psoriatic arthritis (PsA) under OI were proposed to switch to CT-P13 at the same regimen. A prospective cohort of infliximab-naïve patients beginning CT-P13 and a retrospective cohort of patients treated with OI were used as controls. The primary outcome was to evaluate the retention rate of CT-P13. Secondary outcomes were the switch acceptance rate, reasons of failure and safety. RESULTS:Switch was proposed to 100 patients and accepted by 89 of them (63 AS, 12 PsA and 14 RA). After a median follow-up of 33 weeks, 72% of patients were still treated with CT-P13. This retention rate was significantly lower than the one found in our retrospective and prospective control cohorts: 88% and 90% respectively (P-value=0.0002). Within patients who asked to be reswitched to OI, 13/25 (52%) presented clinical disease activity, one developed serum sickness and 11 (44%) presented no objective activity. A subanalysis excluding these 11 patients abrogated difference in retention rates between the 3 cohorts (P-value=0.453). After reswitching to OI, patients without objective disease activity claimed to recover original efficacy. CONCLUSIONS:Retention rate was lower after switching from OI to CT-P13 compared to our control cohorts. However, this difference faded after excluding patients without objective clinical activity, suggesting a reluctance of patients to the switch and a negative perception of the biosimilar.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Scherlinger M,Germain V,Labadie C,Barnetche T,Truchetet ME,Bannwarth B,Mehsen-Cetre N,Richez C,Schaeverbeke T,FHU ACRONIM.doi
10.1016/j.jbspin.2017.10.003subject
Has Abstractpub_date
2018-10-01 00:00:00pages
561-567issue
5eissn
1297-319Xissn
1778-7254pii
S1297-319X(17)30189-6journal_volume
85pub_type
杂志文章相关文献
JOINT BONE SPINE文献大全abstract：OBJECTIVES:To develop recommendations for TNFalpha antagonist therapy in patients with spondyloarthropathies. METHODS:The Delphi consensus procedure was used to select questions, to which evidence-based answers were sought in the literature. Expert opinion was used when needed to estimate the risks and benefits of TNF...
journal_title：Joint bone spine
pub_type： 杂志文章,实务指引
doi：10.1016/j.jbspin.2006.02.005
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVES:To examine the effects of soccer in relation with the hormonal concentration, on the bone mass of young Tunisian players at different pubertal stages. METHODS:Two groups of 152 young boys (age: 13.3+/-0.9 years) participated in this study: (1) 91 soccer players, and (2) 61 non-athletic boys used as control ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2008.03.002
更新日期：2009-01-01 00:00:00
abstract：:Drug-induced aseptic meningitis is uncommon and occurs primarily in patients with autoimmune disease. We report the first known case of leflunomide-induced aseptic meningitis, in a patient with rheumatoid arthritis. ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/S1297-319X(03)00127-1
更新日期：2004-05-01 00:00:00
abstract：OBJECTIVES:To describe the care trajectories of adults aged ≥50 years with fragility fractures in France. METHODS:A postal questionnaire was sent to 15,000 individuals aged ≥50 years extracted from a representative panel of the French population (METASKOPE) in April-May 2018. Respondents experiencing a single fragilit...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2020.04.007
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:Hypophosphatasia (HP; MIM 241510) is an inborn error of bone metabolism, characterized by a genetic defect in the gene of the tissue-non-specific alkaline phosphatase TNSALP. Long-term data on bone mineral density measurements are not available. METHODS:We have analyzed changes of bone mineral density (pQCT ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2006.06.017
更新日期：2007-05-01 00:00:00
abstract：:We report the case of a 38-year-old man who presented with severe diarrhea, weight loss of 10 kg, ankles paresthesia and severe motor weakness in the left fibular nerve territory after introduction of azathioprine and corticosteroid for proteinuria. Coloscopy and gastroscopy revealed a typical aspect of Whipple diseas...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2013.10.007
更新日期：2014-05-01 00:00:00
abstract：:Conventional chemotherapies are no longer the only treatment in multiple myelomatosis. High-dose chemotherapy and autologous transplantation are not curative but do increase relapse-free survival time in young patients. Thalidomide is efficacious in refractory and relapsing myeloma and its evaluation is going on. Cura...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/s1297-319x(03)00018-6
更新日期：2003-06-01 00:00:00
abstract：OBJECTIVES:In the past decade many countries around the world have produced clinical practice guidelines to assist practitioners in providing a care that is aligned with the best evidence. The aim of this study was to present and compare the most established evidence-based recommendations for the management of chronic ...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2011.03.019
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVES:Rheumatoid arthritis (RA)-associated lung involvement is a cause of mortality. This study aimed to evaluate mortality rate and mortality-associated factors in RA patients with high-resolution computed tomography (HRCT)-proven lung involvement. METHODS:Patients followed-up for RA between 2010 and 2018 were e...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2021.105133
更新日期：2021-01-20 00:00:00
abstract：UNLABELLED:The role of epidural fibrosis in postoperative sciatica is unclear. Few therapeutic trials have been published. We evaluated the mechanical effects of forceful saline injections through the sacrococcygeal hiatus comparatively with glucocorticoid injections. PATIENTS AND METHODS:Forty-seven patients with pos...
journal_title：Joint bone spine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s1297-319x(00)00234-7
更新日期：2001-02-01 00:00:00
abstract：OBJECTIVES:This study explores changes in the bone homeostasis by testing the N-terminal collagen type I extension propeptide (PINP) marker for osteo-formation and the carboxy-terminal region of collagen type I (CTX-I) marker for osteo-resorption in patients taking tocilizumab for polymyalgia rheumatica (PMR). METHODS...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2020.105117
更新日期：2020-12-07 00:00:00
abstract：OBJECTIVES:This study was performed to investigate whether leptin mRNA expression is increased from peripheral blood mononuclear cells (PBMCs) of patients with active ankylosing spondylitis (AS) and whether it stimulates the production of pro-inflammatory cytokines. METHODS:Twenty patients with active AS were enrolled...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2008.04.018
更新日期：2009-03-01 00:00:00
abstract：:C-reactive protein (CRP) is an acute-phase protein whose concentration rises sharply during the inflammatory response (1000-fold). CRP belongs to the pentraxin family of proteins, of which a key property is the ability to opsonize apoptotic cells, which can then undergo phagocytosis without triggering an inflammatory ...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2010.04.010
更新日期：2010-10-01 00:00:00
abstract：:Familial arthropathy associated with congenital camptodactyly has been previously recognized as a definite clinical entity in the literature. The clinical spectrum of this disease seems to be variable. The typical features of congenital camptodactyly, arthropathy, coxa vara and pericarditis (CACP syndrome) appear to b...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2013.01.010
更新日期：2013-10-01 00:00:00
abstract：:Clinical data suggested that parathyroid hormone (PTH) might be effective in improving bone mass in patients with osteoporosis, providing its resorptive effects, which are particularly marked at cortical sites, were kept under control. We reviewed the evidence that intermittent PTH therapy is a valid treatment option ...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2005.11.007
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVES:Severe hidradenitis suppurativa (HS), under infliximab, can be associated with different forms of arthritis whose mechanism is unclear. Our objective is to establish the frequency and clinical presentation of new-onset arthritis in HS under infliximab. METHODS:Severe HS patients under infliximab were follow...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2015.01.020
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:Sleep quality is diminished in patients with psoriatic arthritis (PsA) and close to 40% of PsA patients consider sleep difficulties a priority domain. This work analyzes determinants of impaired sleep in patients with PsA. METHODS:This was a cross-sectional analysis of an observational study (ReFlap, NCT NCT...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2020.03.014
更新日期：2020-10-01 00:00:00
abstract：:Carpal tunnel syndrome is the most common nerve entrapment syndrome. The majority of cases are due to compression or irritation of the median nerve in the carpal canal. It is diagnosed clinically, often being confirmed by an electromyogram, while ultrasonography criteria have become increasingly useful for the diagnos...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2017.11.003
更新日期：2018-10-01 00:00:00
abstract：:Ultrasonography is currently widely used in the rheumatology practice. Although mainly performed to study peripheral joint, several articles have underlined its interest to study spinal anatomy. However, its ability to provide diagnostic features is unknown. We studied the case of a 25-year-old woman having low back p...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2015.09.009
更新日期：2016-07-01 00:00:00
abstract：:We describe a patient in whom sporadic Creutzfeldt-Jakob disease (sCJD) occurred one year after the onset of etanercept therapy for rheumatoid arthritis (RA). This association could be a chance occurrence. However, TNF-alpha has been implicated in the pathogenesis of neurodegeneration in sCJD and etanercept might wors...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2009.05.016
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:Musculoskeletal pain is a common complaint among patients with primary Sjogren's syndrome (pSS). Joints clinical examination is oftenly normal. A periarticular origin of this pain may be possible. Since clinical examination lacks sensitivity and precision, the use of musculoskeletal ultrasound (US) is more in...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2020.03.003
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVES:To examine beliefs about cracking sounds heard during high-velocity low-amplitude (HVLA) thrust spinal manipulation in individuals with and without personal experience of this technique. METHODS:We included 100 individuals. Among them, 60 had no history of spinal manipulation, including 40 who were asymptom...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2017.04.006
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Infliximab (IFX) can be immunogenic for humans and lead to the formation of antibodies against IFX (anti-IFX Ab), which could induce acquired IFX resistance. OBJECTIVE:To test whether the presence of anti-IFX Ab and residual circulating IFX levels are associated with acquired IFX resistance in RA. METHODS:...
journal_title：Joint bone spine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jbspin.2010.02.021
更新日期：2010-07-01 00:00:00
abstract：:Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic nonbacterial osteomyelitis, is an orphan disease that manifests as recurrent flares of inflammatory bone pain with or without a fever. The pain is related to one or more foci of nonbacterial osteomyelitis. To distinguish unifocal CRMO from a tumo...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2011.02.010
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Behcet's disease (BD) may complicate with arterial and venous thrombosis. The purpose of this work is to evaluate in an Italian group of BD patients with thrombotic events a large panel of inherited and acquired thrombophilic factors. METHODS:Thirty BD patients, of which nine with previously arterial or ven...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2010.02.022
更新日期：2010-07-01 00:00:00
abstract：:We report a case of Behçet's disease that presented as protracted fever of unknown origin. The diagnosis was established when a thromboembolic event and ora3l aphthous ulcers occurred simultaneously. Antibiotics had no effect on the fever, which resolved when glucocorticoid and anticoagulant therapy was given. Among c...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2003.12.003
更新日期：2005-03-01 00:00:00
abstract：:[(18)F]fluorodeoxyglucose-positron emission tomography (FDG-PET) has demonstrated its usefulness in giant cell arteritis, Takayasu's arteritis, and unclassified aortitis. FDG-PET imaging could be more effective than CT-scan or magnetic resonance imaging in detecting the earliest stages of vascular wall inflammation. D...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2012.11.003
更新日期：2013-07-01 00:00:00
abstract：:Despite therapeutic innovations in the past 20 years, glucocorticoids (GC) are still widely used for the symptomatic treatment of rheumatoid arthritis (RA). Studies have demonstrated the clinical and structural efficacy of moderate doses (i.e. 30-60 mg/d) GC in addition to disease modifying anti-rheumatic drug (DMARD)...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2017.12.002
更新日期：2018-07-01 00:00:00
abstract：:Vertebral osteonecrosis classically presents with an intravertebral vacuum cleft phenomenon or a fluid-filled cleft on MR images. These clefts are usually found in older patients presenting with more severe fractures, more significant collapse and instability. Therefore, although considered for a long time as pathogno...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2007.05.010
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the geoepidemiology of Sjögren's syndrome (SS) in Latin America. METHODS:This was a three phase study in which original data from a Colombian cohort of patients with SS is presented, followed by a systematic review of Colombian and Latin American studies. Lastly, the geoepidemiology of SS in Lati...
journal_title：Joint bone spine
pub_type： 杂志文章,meta分析
doi：10.1016/j.jbspin.2019.02.004
更新日期：2019-10-01 00:00:00
