Abstract：
OBJECTIVES:In a previous study, we determined the costs over 6 months to the French public health insurance system of Hylan GF-20 (Synvisc) in 66 patients with knee osteoarthritis. Here, we compared the medicoeconomic benefits over 9 months in 506 patients given Hylan GF-20 or conventional treatment for knee osteoarthritis. PATIENTS AND METHODS:This prospective randomized study was conducted from October 1998 to February 2000. Clinical status was evaluated using the Lequesne index, the WOMAC index, and the SF12 quality-of-life questionnaire. Medical and sick leave costs to the public health insurance system were determined. RESULTS:Effectiveness criteria were evaluable in all 506 patients. Significant clinical improvements were noted from the first month to the end of the 9-month study period in the Synvisc group. A mean 2-point difference in the Lequesne index area-under-the-curve was found in favor of Synvisc (P < 0.0001). Mean medical and sick leave costs per patient over 9 months were 829.10 in the Synvisc group and 829.40 in the conventional treatment group. CONCLUSION:This study carried out over 9 months in a large population confirms that Synvisc viscosupplementation is more effective than conventional treatment, at no additional cost. It takes a step toward answering the request of international experts for medicoeconomic data on viscosupplementation for osteoarthritis.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Kahan A,Lleu PL,Salin Ldoi
10.1016/s1297-319x(03)00043-5subject
Has Abstractpub_date
2003-08-01 00:00:00pages
276-81issue
4eissn
1297-319Xissn
1778-7254pii
S1297319X03000435journal_volume
70pub_type
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