Abstract：
OBJECTIVE:To investigate the cutaneous tolerance of febuxostat in gouty patients with skin intolerance to allopurinol. METHODS:We identified all gouty patients who had sequentially received allopurinol and febuxostat in the rheumatology departments of 4 university hospitals in France and collected data from hospital files using a predefined protocol. Patients who had not visited the prescribing physician during at least 2 months after febuxostat prescription were excluded. The odds ratio (OR) for skin reaction to febuxostat in patients with a cutaneous reaction to allopurinol versus no reaction was calculated. For estimating the 95% confidence interval (95% CI), we used the usual Wald method and a bootstrap method. RESULTS:In total, 113 gouty patients had sequentially received allopurinol and febuxostat; 12 did not visit the prescribing physician after febuxostat prescription and were excluded. Among 101 patients (86 males, mean age 61±13.9 years), 2/22 (9.1%) with a history of cutaneous reactions to allopurinol showed skin reactions to febuxostat. Two of 79 patients (2.5%) without a skin reaction to allopurinol showed skin intolerance to febuxostat. The ORs were not statistically significant with the usual Wald method (3.85 [95% CI 0.51-29.04]) or bootstrap method (3.86 [95% CI 0.80-18.74]). CONCLUSION:The risk of skin reaction with febuxostat seems moderately increased in patients with a history of cutaneous adverse events with allopurinol. This moderate increase does not support the cross-reactivity of the two drugs.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Bardin T,Chalès G,Pascart T,Flipo RM,Korng Ea H,Roujeau JC,Delayen A,Clerson Pdoi
10.1016/j.jbspin.2015.07.011subject
Has Abstractpub_date
2016-05-01 00:00:00pages
314-7issue
3eissn
1297-319Xissn
1778-7254pii
S1297-319X(15)00288-2journal_volume
83pub_type
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