Abstract:
:Apheresis has been used in the treatment of severe systemic vasculitides, in conjunction with immunosuppressive therapies, for over 40 years. The aim is to rapidly remove autoantibodies or circulating immune complexes from the plasma. The two main indications at present are vasculitis associated with Antineutrophil Cytoplasmic Antibodies (ANCAs) manifesting as severe renal involvement and/or intraalveolar hemorrhage and antiglomerular basement membrane disease (Goodpasture syndrome). The ongoing PEXIVAS randomized controlled trial is assessing plasmapheresis to treat ANCA-associated vasculitis with or without severe renal involvement or intraalveolar hemorrhage. The two main apheresis techniques used to treat systemic vasculitis are plasmapheresis (by filtration, centrifugation, or double filtration) and immunoadsorption. The advantages and drawbacks of each technique are discussed here. Whether one technique is superior over the other in the current indications has not been proven.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Moussi-Frances J,Sallée M,Jourde-Chiche Ndoi
10.1016/j.jbspin.2017.06.001subject
Has Abstractpub_date
2018-03-01 00:00:00pages
177-183issue
2eissn
1297-319Xissn
1778-7254pii
S1297-319X(17)30117-3journal_volume
85pub_type
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