Apheresis to treat systemic vasculitis.

Abstract:

:Apheresis has been used in the treatment of severe systemic vasculitides, in conjunction with immunosuppressive therapies, for over 40 years. The aim is to rapidly remove autoantibodies or circulating immune complexes from the plasma. The two main indications at present are vasculitis associated with Antineutrophil Cytoplasmic Antibodies (ANCAs) manifesting as severe renal involvement and/or intraalveolar hemorrhage and antiglomerular basement membrane disease (Goodpasture syndrome). The ongoing PEXIVAS randomized controlled trial is assessing plasmapheresis to treat ANCA-associated vasculitis with or without severe renal involvement or intraalveolar hemorrhage. The two main apheresis techniques used to treat systemic vasculitis are plasmapheresis (by filtration, centrifugation, or double filtration) and immunoadsorption. The advantages and drawbacks of each technique are discussed here. Whether one technique is superior over the other in the current indications has not been proven.

journal_name

Joint Bone Spine

journal_title

Joint bone spine

authors

Moussi-Frances J,Sallée M,Jourde-Chiche N

doi

10.1016/j.jbspin.2017.06.001

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

177-183

issue

2

eissn

1297-319X

issn

1778-7254

pii

S1297-319X(17)30117-3

journal_volume

85

pub_type

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