Abstract：
OBJECTIVES:Diagnosis of systemic sclerosis (SSc) is partially determined by the presence of specific autoantibodies often associated with specific clinical features. Recent studies report the presence of ACPA in SSc. We aimed to evaluate the prevalence of ACPA in SSc and to assess their influence on clinical presentation of SSc. METHODS:A systematic literature search was performed using PubMed and Cochrane databases' publications between 1999 and March 2017. Search terms were: "systemic sclerosis [MeSH] AND (ACPA OR anti-CCP OR rheumatoid factor OR cohort OR value diagnostic)". In a first step, we selected cohorts with >50 SSc patients with ACPA identification, for ACPA frequency determination. In a second step, we included studies that analysed clinical profiles according to ACPA status. Meta-analyses were performed when at least two studies were available. RESULTS:First, we identified 13 observational studies with a total of 1231 SSc patients. The mean prevalence of ACPA in SSc was 9.2%. Secondly, we identified nine studies reporting clinical aspects according to ACPA status. Our meta-analyses showed a significant association between ACPA positivity and the presence of arthritis (odds ratio (OR)=22.48 [10.71-47.21]), joint erosions seen on X-rays (OR=14.79 [6.38-34.28]), pulmonary fibrosis (OR=2.75 [1.21-6.24]), oesophagus involvement (OR=2.72 [1.05-7.07]), and diffuse skin involvement (OR=2.21 [1.21-4.03]). CONCLUSIONS:The prevalence of ACPA in scleroderma is 9.2%. Our meta-analysis shows an increased risk for erosive arthritis, pulmonary fibrosis, oesophagus involvement and diffuse skin involvement, in patients with ACPA-positive SSc. ACPA should be systematically included in SSc assessment.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Laustriat G,Ruyssen-Witrand A,Constantin A,Barnetche T,Adoue D,Cantagrel A,Degboé Ydoi
10.1016/j.jbspin.2017.11.006subject
Has Abstractpub_date
2018-03-01 00:00:00pages
147-153issue
2eissn
1297-319Xissn
1778-7254pii
S1297-319X(17)30196-3journal_volume
85pub_type
杂志文章,meta分析相关文献
JOINT BONE SPINE文献大全abstract：:Neural fibrolipoma or fibrolipomatous hamartoma is an uncommon benign tumor that usually arises in the median nerve. Fibrofatty tissue proliferates around the nerve and infiltrates the epineurium and perineurium. We report a case of fibrolipomatous hamartoma of the left median nerve in an 18-year-old woman. Our object...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2006.02.012
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVE:Sleep quality is diminished in patients with psoriatic arthritis (PsA) and close to 40% of PsA patients consider sleep difficulties a priority domain. This work analyzes determinants of impaired sleep in patients with PsA. METHODS:This was a cross-sectional analysis of an observational study (ReFlap, NCT NCT...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2020.03.014
更新日期：2020-10-01 00:00:00
abstract：:Schnitzler syndrome is characterized by monoclonal IgM gammopathy, urticaria, recurrent fever, evidence of inflammation, bone pain, and arthralgia, occasionally in combination with lymphadenopathy and/or hepatosplenomegaly. Only about 80 cases have been reported to date. Development of a hematological malignancy is th...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2007.07.014
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:Information and education are recommended for patients with inflammatory arthritis including rheumatoid arthritis (RA) and spondyloarthritis (SpA). However, there is no consensus on which knowledge is essential to enhance patients' self-management. The aim of this study was to determine such knowledge. METHO...
journal_title：Joint bone spine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jbspin.2019.06.006
更新日期：2019-11-01 00:00:00
abstract：:Once remission or low disease activity (LDA) is attained in established rheumatoid arthritis (RA) patients, attempting disease-modifying anti-rheumatic drug (DMARD) tapering appears to be a viable option to avoid patient overtreatment. Potential benefits include reduction in the treatment burden and the risk of advers...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2018.02.002
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVES:To describe the features, prognosis, and treatment of vascular involvement in Behçet's disease (BD). PATIENTS:Among 140 patients with BD seen at the Hôtel-Dieu Hospital in Beirut between 1980 and 2000, 18 (13%) had vascular involvement and were included in this retrospective study. All these patients fulfil...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/s1297-319x(03)00076-9
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the long-term efficacy of steroid injection for plantar fasciitis using clinical parameters and high-resolution ultrasonography. MATERIAL AND METHODS:Thirty patients (27 female and three male) with plantar fasciitis and 30 healthy controls matched by age, gender and body mass index (BMI), were en...
journal_title：Joint bone spine
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbspin.2004.03.006
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVES:Severe hidradenitis suppurativa (HS), under infliximab, can be associated with different forms of arthritis whose mechanism is unclear. Our objective is to establish the frequency and clinical presentation of new-onset arthritis in HS under infliximab. METHODS:Severe HS patients under infliximab were follow...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2015.01.020
更新日期：2015-10-01 00:00:00
abstract：:Androgen-deprivation therapy (ADT) in patients with prostate cancer can be achieved surgically or chemically, notably by prescribing LHRH analogs. Major bone loss occurs rapidly in both cases, due to the decrease in testosterone levels, and can increase the fracture risk. The objective of developing these recommendati...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2018.09.017
更新日期：2019-01-01 00:00:00
abstract：:In the 20-50-year age group, hip pain usually indicates dysplasia. Chronic mechanical pain is the usual pattern, although acute pain caused by avulsion or degeneration of the labrum may occur. The morphological characteristics of the dysplastic hip should be evaluated, and the link between the dysplasia and the osteoa...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2006.09.001
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVE:We assessed the efficacy, tolerance and cost of a 3 mg/kg starting dose of infliximab for ankylosing spondylitis (AS) and psoriatic arthritis (PsA). METHODS:We retrospectively followed-up 45 biologic-naive consecutive patients (11 with axial AS, 24 with axial and peripheral [mixed] AS and 10 with PsA) who we...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2010.04.017
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVES:To develop recommendations about pharmacotherapy (excluding biotherapeutic agents) in patients with axial forms of ankylosing spondylitis (AS) seen in everyday clinical practice. METHODS:The recommendations were based on evidence from the literature. First, a scientific committee used a Delphi procedure to ...
journal_title：Joint bone spine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jbspin.2007.04.003
更新日期：2007-07-01 00:00:00
abstract：:Interferons (IFNs) play essential roles in regulating osteoclast differentiation and bone resorption. Over the last decade, we have seen tremendous developments in our understanding of the mechanisms by which interferons regulate osteoclastogenesis. Of the type I interferons, IFN-β inhibits osteoclastogenesis via auto...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2015.07.010
更新日期：2016-05-01 00:00:00
abstract：:A case of severe hyperparathyroidism (HPT), secondary to chronic renal failure, with massive distal phalangeal osteolysis is reported. After parathyroidectomy, brachydactyly and osteosclerosis of the distal phalanges were observed; the phalanx of the thumbs healed with shortened and sclerotic beaked appearance. These ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/s1297-319x(03)00023-x
更新日期：2003-03-01 00:00:00
abstract：:The prominent role for mast cells in the inflammatory response has been increasingly well documented in recent years. Mast cells not only contribute to maintain homeostasis via degranulation and to generate IgE-mediated allergic reactions, but also sit at a major crossroads for both innate and adaptive immune response...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2012.08.013
更新日期：2013-03-01 00:00:00
abstract：:Clinical data suggested that parathyroid hormone (PTH) might be effective in improving bone mass in patients with osteoporosis, providing its resorptive effects, which are particularly marked at cortical sites, were kept under control. We reviewed the evidence that intermittent PTH therapy is a valid treatment option ...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2005.11.007
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVES:To assess the effect of periodontal treatment on clinical and biochemical parameters of rheumatoid arthritis (RA) and quality of life (QoL) in patients with moderately active RA who were diagnosed with periodontitis. METHODS:In this open-label randomised controlled trial, RA subjects (n = 22) were allocated...
journal_title：Joint bone spine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jbspin.2019.02.006
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:To explore acceptance and retention rate of biosimilar CT-P13 after switching from originator infliximab (OI) in patients with various rheumatic diseases. METHODS:Patients with stable rheumatoid arthritis (RA), ankylosing spondylitis (AS) or psoriatic arthritis (PsA) under OI were proposed to switch to CT-P1...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2017.10.003
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVES:Candidate cell types for disc cell transplantation therapy include anulus fibrosus (AF) cells, chondrocytes, and bone marrow derived cells (BMDCs). We compared the disc matrix production in these three types of cells, before and after stimulation with rhBMP-2. There is no study extant that compares these thr...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2008.02.021
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:Rheumatoid arthritis (RA) is a common, complex autoimmune disease known to be associated with inheritance of certain human leukocyte antigen (HLA)-DR alleles in different populations. This study investigated the association of DRB1 alleles in Kuwaiti patients with RA. MATERIALS AND METHODS:DRB1 alleles were...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2004.12.006
更新日期：2006-01-01 00:00:00
abstract：:To assess the bone mineral density status in primary hyperparathyroidism (PHPT), we studied 64 females with PHPT and 17 healthy women. Regional BMD (arms, trunk, legs) from the whole body scan and conventional sites (lumbar spine, femur, radius) were assessed by DXA. Quantitative ultrasound (QUS) imaging measurements ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2004.08.015
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:To report our single centre experience in treating 4 children affected by childhood primary central nervous system vasculitis (cPACNS) using mycophenolate mofetil (MMF). METHODS:From December 2011 to August 2015, 4 patients (3 males; age range: 9 months-13 years) affected by cPACNS were collected. Enrolled c...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2016.12.004
更新日期：2017-05-01 00:00:00
abstract：:Pain is an ubiquitous symptom in osteoarticular diseases, occurring much more commonly than stiffness or disability. OA of the knee, hand, or hip affects around 20% of adults in various populations and is dramatically increasing in many countries, mostly related to age and obesity, leading to an increased number of pe...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2017.08.002
更新日期：2018-07-01 00:00:00
abstract：:Pseudo-xanthoma elasticum (PXE) is an inherited disorder of the connective tissue characterized by cutaneous, ocular and vascular lesions. Coexisting PXE and rheumatoid arthritis (RA) is rare because three cases have only been described. We report three new cases of this association. Analysis of these six cases failed...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/s1297-319x(01)00317-7
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVE:Previous studies reported that anti-CCP antibody positivity predicts good response to rituximab (RTX) in rheumatoid arthritis (RA). A quantitative approach to such possibility could be a good way to detect the subset of patients most likely to respond. We investigated whether serum anti-CCP antibody titres co...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2014.06.001
更新日期：2014-10-01 00:00:00
abstract：:Carpal tunnel syndrome is the most common nerve entrapment syndrome. The majority of cases are due to compression or irritation of the median nerve in the carpal canal. It is diagnosed clinically, often being confirmed by an electromyogram, while ultrasonography criteria have become increasingly useful for the diagnos...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2017.11.003
更新日期：2018-10-01 00:00:00
abstract：:Stickler syndrome is a group of rare genetic conditions (incidence, 1/7500 births) related to mutations in the collagen genes. Both the mutations and the clinical features vary widely across affected patients. The main manifestations are craniofacial birth defects, bone and joint symptoms, ocular abnormalities, and he...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2010.03.012
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVES:To examine the effects of soccer in relation with the hormonal concentration, on the bone mass of young Tunisian players at different pubertal stages. METHODS:Two groups of 152 young boys (age: 13.3+/-0.9 years) participated in this study: (1) 91 soccer players, and (2) 61 non-athletic boys used as control ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2008.03.002
更新日期：2009-01-01 00:00:00
abstract：:Recent progress in the management of rheumatoid arthritis (RA) is turning attention toward comorbidities, such as diabetes. The objectives of this review are to clarify the links between RA and diabetes and to assess potential effects of disease-modifying antirheumatic drugs (DMARDs) on diabetes. The increased insulin...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2016.09.001
更新日期：2017-07-01 00:00:00
abstract：:The combination of synovitis, acne, pustulosis, hyperostosis and aseptic osteitis is known as SAPHO syndrome. Osteitis involves the anterior chest, particularly the sternoclavicular and upper costosternal junctions. Diagnosis is difficult when there are no typical skin and bone lesions and differential diagnosis inclu...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2007.05.009
更新日期：2008-05-01 00:00:00
