Intra-articular botulinum toxin A as an adjunctive therapy for refractory joint pain in patients with rheumatoid arthritis receiving biologics: a report of two cases.


:We report the use of intra-articular Botulinum toxin A in two RA patients with persistently painful monoarthritis in ankle/feet joints. Both patients had monarticular pain despite a good response of all other joints to a combination therapy that included anti-tumor necrosis factor therapy. Both patients had failed intra-articular corticosteroid injections and declined surgical options. After a single, "off-label", intra-articular injection of Botulinum toxin A into the right ankle (100 unit) and left first metatarsophalangeal joint (25 unit), respectively, pain and function improved significantly (> or =40%) in both patients. Durable response with improvement of pain and function lasting 15-18 months was noted (follow-up continuing). Ankle joint swelling resolved by 15 months and MTP joint swelling by one month. Intra-articular BoNT/A may be an additional therapeutic option in RA patients with persistent monoarthritis. A randomized study is underway to confirm these findings.


Joint Bone Spine


Joint bone spine


Singh JA,Mahowald ML




Has Abstract


2009-03-01 00:00:00














  • Acromegaly is associated with vertebral deformations but not vertebral fractures: Results of a cross-sectional monocentric study.

    abstract:OBJECTIVES:Patients with acromegaly appear to be at increased risk of vertebral fractures despite normal bone mineral density. We investigated the prevalence of vertebral fractures in a cohort of acromegalic patients under 80 years of age. METHODS:Monocentric cross-sectional study performed at Nantes University Hospit...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Plard C,Hochman C,Hadjadj S,Le Goff B,Maugars Y,Cariou B,Drui D,Guillot P

    更新日期:2020-12-01 00:00:00

  • A critical review of weight loss recommendations before total knee arthroplasty.

    abstract:OBJECTIVE:Increased infection risk after total knee arthroplasty (TKA) in patients with a higher body mass index (BMI), particularly a BMI ≥40 kg/m2, suggests that BMI reduction (through weight loss) prior to TKA may be important. However, the impact of weight loss on TKA risk reduction is unclear. Further, weight loss...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Godziuk K,Prado CM,Beaupre L,Jones CA,Werle J,Forhan M

    更新日期:2020-12-02 00:00:00

  • Verification of Berlin algorithm for diagnosing undifferentiated spondyloarthropathy patients in Chinese population.

    abstract:OBJECTIVE:To evaluate the diagnosing value of the Berlin algorithm, comparing to that of the established ESSG and Amor criteria in Chinese patients with undifferentiated spondyloarthropathy. METHODS:A total of 92 clinically diagnosed undifferentiated spondyloarthropathy patients with axial involvement were compared to...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Liao Z,Gu J,Huang F,Lin Z,Zhao L,Yu B

    更新日期:2009-03-01 00:00:00

  • Contribution of autoantibodies to the diagnosis and nosology of inflammatory muscle disease.

    abstract::The myositides are systemic autoimmune conditions of which the most important are polymyositis, dermatomyositis, and inclusion body myositis. In addition to the classic clinical diagnostic criteria, myositis-specific autoantibodies were identified about 15 years ago. Among the dozen or so myositis-specific autoantibod...

    journal_title:Joint bone spine

    pub_type: 杂志文章,评审


    authors: Sordet C,Goetz J,Sibilia J

    更新日期:2006-12-01 00:00:00

  • Assessing damage in individual joints in rheumatoid arthritis: a new method based on the Larsen system.

    abstract:OBJECTIVES:To evaluate observer agreement using the Larsen system (LS) and a Modified Larsen system (ML) when assessing individual joints of the hands and wrists in rheumatoid arthritis, and to compare the two systems. To determine the minimally important difference (MID) for the ML. METHODS:Thirty radiographs of hand...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Zangger P,Kachura JR,Bombardier C,Redelmeier DA,Badley EM,Bogoch ER

    更新日期:2004-09-01 00:00:00

  • Prevalence of gout with comorbidity aggregations in southern Taiwan.

    abstract:OBJECTIVE:Comorbidity is an important concern for chronic gout patients. We evaluated the relationship between comorbidity profiles and gout in Taiwan aborigines and Taiwanese Han. METHODS:We used the claims data from the Taiwan national health insurance database for 2004 to 2006. Physician-diagnosed gout and comorbid...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Tu FY,Lin GT,Lee SS,Tung YC,Tu HP,Chiang HC

    更新日期:2015-01-01 00:00:00

  • Familial hypocalciuric hypercalcemia revealed by chondrocalcinosis.

    abstract:BACKGROUND:Calcium pyrophosphate dihydrate crystal deposition disease (CPPD-CDD) has been associated to hypercalcemia. Familial hypocalciuric hypercalcemia (FHH) is a rare but important consideration in the differential diagnosis of hypercalcemia. This autosomal dominantly inherited condition is characterized by elevat...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Volpe A,Guerriero A,Marchetta A,Caramaschi P,Furlani L

    更新日期:2009-12-01 00:00:00

  • Premature epiphyseal closure in an adolescent treated by retinoids for acne: an unusual cause of anterior knee pain.

    abstract::Retinoids are effective and widely prescribed in the treatment of severe acne. However their use can be associated with numerous side effects. Some rare cases of premature epiphyseal closure were reported. We present the case of a sixteen-year-old soccer player referred for progressive anterior pain in both knees, evo...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Luthi F,Eggel Y,Theumann N

    更新日期:2012-05-01 00:00:00

  • Shoulder surgery: from cuff repair to joint replacement. An update.

    abstract::REPAIRING FULL THICKNESS CUFF TEARS.--Despite the sound rationale for repairing full-thickness rotator cuff tears, the procedure may fail to restore cuff integrity, which is indispensable to optimal cuff function. The functional role of each cuff muscle and the factors associated with anatomic failure (particularly th...

    journal_title:Joint bone spine



    authors: Goutallier D,Postel JM,Zilber S,Van Driessche S

    更新日期:2003-12-01 00:00:00

  • Distraction to treat knee osteoarthritis.

    abstract::The objective of this article is to review data on joint distraction used to treat knee osteoarthritis. Joint distraction is a surgical procedure in which the two bony ends of the joint are gradually pulled apart then kept separated for 2 months in an external fixation frame. Weight bearing is continued to ensure vari...

    journal_title:Joint bone spine

    pub_type: 杂志文章,评审


    authors: Flouzat-Lachaniette CH,Roubineau F,Heyberger C,Bouthors C

    更新日期:2017-03-01 00:00:00

  • Creutzfeldt-Jakob disease in a patient treated by etanercept for rheumatoid arthritis (RA): just a coincidence?

    abstract::We describe a patient in whom sporadic Creutzfeldt-Jakob disease (sCJD) occurred one year after the onset of etanercept therapy for rheumatoid arthritis (RA). This association could be a chance occurrence. However, TNF-alpha has been implicated in the pathogenesis of neurodegeneration in sCJD and etanercept might wors...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Soubrier M,Haïk S,Hauw JJ,Corvol JC,Lyon-Caen O,Dougados M

    更新日期:2010-03-01 00:00:00

  • Osteitis pubis after Marshall-Marchetti-Krantz urethropexy.

    abstract::We report a case of osteitis pubis after Marshall-Marchetti-Krantz urethropexy. There are several theories on the pathogenesis of the postoperative osteitis pubis and inconsistent results with a wide variety of treatments. Also, osteomyelitis and osteitis pubis can have identical symptoms. In our case, the use of a Mi...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Garcia-Porrua C,Picallo JA,Gonzalez-Gay MA

    更新日期:2003-02-01 00:00:00

  • Elderly onset of primary Sjögren's syndrome: clinical manifestations, serological features and oral/ocular diagnostic tests. Comparison with adult and young onset of the disease in a cohort of 336 Italian patients.

    abstract:OBJECTIVES:To study and compare the clinical and serological features of patients with elderly versus adult and younger onset of primary Sjögren's syndrome (pSS). METHODS:We analyzed retrospectively 336 consecutive pSS patients followed at our unit. They were subdivided into three groups according to the age at diseas...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Botsios C,Furlan A,Ostuni P,Sfriso P,Andretta M,Ometto F,Raffeiner B,Todesco S,Punzi L

    更新日期:2011-03-01 00:00:00

  • IgD kappa myeloma: a new case.

    abstract:UNLABELLED:IgD myeloma, which is particularly severe, accounts for only 1-3% of all myeloma cases, and the kappa subtype contributes only 10-30% of IgD myelomas. We report a new case. CASE-REPORT:A 59-year-old man was admitted for inflammatory low back pain with L5 sciatica and diffuse bone pain. The symptoms had been...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Amine B,Benbouazza K,Harzy T,Rahmouni R,Guedira N,Lazrak N,Hajjaj-Hassouni N

    更新日期:2004-07-01 00:00:00

  • Clinical and functional status in 88 rheumatoid arthritis patients followed for 15 years or more by office-based (n = 41) or hospital-based (n = 47) physicians.

    abstract:OBJECTIVE:To determine the very long-term clinical and functional outcomes in rheumatoid arthritis (RA) patients followed by office-based or hospital-based physicians. PATIENTS AND METHODS:A questionnaire including items on clinical outcomes (active disease, remission, burn-out) and the Health Assessment Questionnaire...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Laborie Y,Berthelot JM,Alliaume C,Baron J,Caumon JP,Desmas V,Rossard A,Maugars Y,Prost A

    更新日期:2002-03-01 00:00:00

  • Optimizing combination rifampin therapy for staphylococcal osteoarticular infections.

    abstract::Staphylococcus spp. causes more than half of all osteoarticular infections of native structures or implanted material. The ability of Staphylococcus spp. to persist within infected bone tissue and to produce a bacterial biofilm, most notably in infections of implanted material, can lead to treatment failures and micro...

    journal_title:Joint bone spine

    pub_type: 杂志文章,评审


    authors: Coiffier G,Albert JD,Arvieux C,Guggenbuhl P

    更新日期:2013-01-01 00:00:00

  • Schnitzler syndrome.

    abstract::Schnitzler syndrome is characterized by monoclonal IgM gammopathy, urticaria, recurrent fever, evidence of inflammation, bone pain, and arthralgia, occasionally in combination with lymphadenopathy and/or hepatosplenomegaly. Only about 80 cases have been reported to date. Development of a hematological malignancy is th...

    journal_title:Joint bone spine

    pub_type: 杂志文章,评审


    authors: Soubrier M

    更新日期:2008-05-01 00:00:00

  • Animal models of HLA-B27-associated diseases: new outcomes.

    abstract::The HLA-B27 molecule is strongly associated with the spondyloarthropathies, a group of chronic inflammatory diseases, affecting the skeleton, the bowel and the skin. This association has been largely studied, but mechanisms of pathology remain unclear. The HLA-B27 transgenic rats develop a spontaneous disease that str...

    journal_title:Joint bone spine

    pub_type: 杂志文章,评审


    authors: Hacquard-Bouder C,Ittah M,Breban M

    更新日期:2006-03-01 00:00:00

  • Kimura disease of extremity: unusual manifestation in a long bone.

    abstract::Kimura's disease is a rare, chronic inflammatory disorder, presenting usually as head and neck swellings and regional cervical lymphadenopathy. The disease is more often described from oriental literature but the osseous manifestations and involvement of extremity are rare and unidentified in literature. We present an...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Varshney MK,Kumar A,Khan SA,Yadav CS

    更新日期:2008-07-01 00:00:00

  • Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy.

    abstract::We report on an unusual case of a 40-year-old Caucasian male displaying severe Kawasaki-like symptoms. The disease lasted for seven years before diffuse coronary aneurysms occurred, leading to the patient's death, despite ongoing treatment by intravenous immunoglobulins (IVIGs). The patient had also been suffering fro...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Soltner E,Neel A,Tiab M,Varin S,Cormier G,Maisonneuve H,Maugars Y,Tanguy G,Hamidou M,Berthelot JM

    更新日期:2009-10-01 00:00:00

  • Reactive macrophage activation syndrome possibly triggered by canakinumab in a patient with adult-onset Still's disease.

    abstract::Macrophage activation syndrome (MAS) is a rare and serious complication of adult-onset Still's disease. We describe a case in a 49-year-old woman with Still's disease refractory to glucocorticoids, methotrexate, and infliximab. Anakinra provided satisfactory disease control for 1 year, after which escape phenomenon oc...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Banse C,Vittecoq O,Benhamou Y,Gauthier-Prieur M,Lequerré T,Lévesque H

    更新日期:2013-12-01 00:00:00

  • Group B streptococcal arthritis.

    abstract::Recent data suggest that group B streptococcal arthritis is being increasingly diagnosed. We retrospectively reviewed the records of patients admitted to our Teaching Hospital Rheumatology Department for septic arthritis between May 2000 and May 2004 and we reviewed the relevant literature to determine the characteris...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Binard A,Devauchelle V,Goulesque K,Jousse S,Saraux A

    更新日期:2006-07-01 00:00:00

  • Gastric bleeding in a patient with rheumatoid arthritis complicated by immune thrombocytopenic purpura.

    abstract::Rheumatoid arthritis, in common with other systemic autoimmune diseases, can involve several other organs presenting with complex immunological manifestations. Immune thrombocytopenic purpura caused by an autoimmune reaction against platelets is an infrequent haematological complications. A female patient with rheumat...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Gál I,Tóth L,Szegedi L,Kiss GG

    更新日期:2008-05-01 00:00:00

  • Aortic involvement in relapsing polychondritis.

    abstract:OBJECTIVE:To assess prevalence of aortic involvement in relapsing polychondritis (RP) patients; to evaluate clinical features and long-term outcome of RP patients exhibiting aortitis, aortic ectasia and/or aneurysm. METHODS:One hundred and seventy-two RP patients underwent aortic computed tomography (CT)-scan; they we...

    journal_title:Joint bone spine

    pub_type: 杂志文章,多中心研究


    authors: Le Besnerais M,Arnaud L,Boutémy J,Bienvenu B,Lévesque H,Amoura Z,Marie I

    更新日期:2018-05-01 00:00:00

  • Acetaminophen as symptomatic treatment of pain from osteoarthritis.

    abstract::Osteoarthritis is a major public health burden. The incidence of osteoarthritis increases with advancing age. Symptomatic treatments aimed at alleviating the pain and thereby restoring joint function form the basis of the treatment. The chronic course requires long-term treatment with special attention to minimizing t...

    journal_title:Joint bone spine

    pub_type: 杂志文章,评审


    authors: Bertin P,Keddad K,Jolivet-Landreau I

    更新日期:2004-07-01 00:00:00

  • Evolution of hydrogels for cartilage tissue engineering of the knee: A systematic review and meta-analysis of clinical studies.

    abstract:INTRODUCTION:In recent years, studies have boosted our knowledge about the biology and disorders of articular cartilage. In this regard, the design of hydrogel-based scaffolds has advanced to improve cartilage repair. However, the efficacy of knee cartilage repair using hydrogels remains unclear. The aim of systematic ...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Hosseini SA,Mohammadi R,Noruzi S,Ganji R,Oroojalian F,Sahebkar A

    更新日期:2020-11-03 00:00:00

  • Forceful sacrococcygeal injections in the treatment of postdiscectomy sciatica. A controlled study versus glucocorticoid injections.

    abstract:UNLABELLED:The role of epidural fibrosis in postoperative sciatica is unclear. Few therapeutic trials have been published. We evaluated the mechanical effects of forceful saline injections through the sacrococcygeal hiatus comparatively with glucocorticoid injections. PATIENTS AND METHODS:Forty-seven patients with pos...

    journal_title:Joint bone spine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Meadeb J,Rozenberg S,Duquesnoy B,Kuntz JL,Le Loët X,Sebert JL,Le Goff P,Fallut M,Marty M,Blévin S,Guggenbuhl P,Chalès G,Duvauferrier R

    更新日期:2001-02-01 00:00:00

  • Real-world care for individuals aged over fifty with fractures in France: Evidence for a wide care gap-The EPIFRACT Study.

    abstract:OBJECTIVES:To describe the care trajectories of adults aged ≥50 years with fragility fractures in France. METHODS:A postal questionnaire was sent to 15,000 individuals aged ≥50 years extracted from a representative panel of the French population (METASKOPE) in April-May 2018. Respondents experiencing a single fragilit...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Briot K,Grange L,Cortet B,Feron JM,Chauvin P,Coulomb A,Alliot-Launois F,Sellami R,Touboul C,Perrin L,Joubert JM,Launois R

    更新日期:2020-10-01 00:00:00

  • Radiographic progression in patients with ankylosing spondylitis according to tumor necrosis factor blocker exposure: Observation Study of Korean Spondyloarthropathy Registry (OSKAR) data.

    abstract:OBJECTIVE:To evaluate the influence of tumor necrosis factor (TNF) blocker on the radiographic progression in ankylosing spondylitis (AS) patients. METHODS:A total of 610 patients were recruited. We stratified two groups (TNF blocker naïve and exposure patients). After then, we analyzed the radiographic spinal progres...

    journal_title:Joint bone spine

    pub_type: 杂志文章


    authors: Kim TJ,Shin JH,Kim S,Sung IH,Lee S,Song Y,Kim TH

    更新日期:2016-10-01 00:00:00

  • Validation of the KOFUS (Knee Osteoarthritis Flare-Ups Score).

    abstract:OBJECTIVE:To develop a diagnostic score for knee osteoarthritis flare-ups and to evaluate its sensitivity and specificity. METHODS:We used two epidemiological databases built using the same methodology. One database was from a general-practice study and served to develop the score, whereas the other was from a rheumat...

    journal_title:Joint bone spine

    pub_type: 杂志文章,多中心研究


    authors: Marty M,Hilliquin P,Rozenberg S,Valat JP,Vignon E,Coste P,Savarieau B,Allaert FA

    更新日期:2009-05-01 00:00:00