Abstract:
:Three experiments were performed to see whether cardiac neurons contribute to the intrinsic control of heart rate in right atria of adult rats. The intrinsic heart rate response (IRR) was examined by raising right atrial pressure from 2 to 8 mmHg for 3 min. In isolated preparations of the right atrium, the IRR was not significantly altered by the addition of either 1 microM atropine (n =6; control +19+/- 3 min(-1) ; atropine+18+/-3 min(-1); (mean /+/-S.E.M.)) or 1 microM propranolol (n = 5; control +22+/- 4 min(-1); ; propranolol +21+/-3 min(-1); ). Tetrodotoxin (0.5 microm) had no effect on the IRR (n = 6; control +37+/-5 min(-1); tetrodotoxin 38+/-5 min(-1); ). In another experiment, 2-day-old rat pups were injected with capsaicin (50 mg kg(-1); treated) or with vehicle(control). There was no difference in the IRR of right atrial preparations taken from control and treated animals after they reached adulthood (control (n = 7) and treated (n = 8): +30+/- 4 and +32+/- 4 min(-1)). The influence of right atrial pressure on the efficacy of vagal stimulation was examined. The rate response to vagal stimulation was reduced similarly in control and treated preparations when pressure was elevated from 2 to 4 mmHg (control and treated: -34+/- 5% and -33+/- 3%). The effectiveness of the capsaicin treatment was confirmed by the depletion of substance P-immunoreactive nerve fibres in cardiac tissues. Together, these results strongly suggest that cardiac neurons are not involved in intrinsic heart rate control.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Wilson SJ,Bolter CPdoi
10.1113/eph8702364subject
Has Abstractpub_date
2002-11-01 00:00:00pages
675-82issue
6eissn
0958-0670issn
1469-445Xjournal_volume
87pub_type
杂志文章abstract:NEW FINDINGS:What is the topic of this review? This review covers recent evidence highlighting the crucial pathophysiological roles and molecular mechanisms of the bone morphogenetic protein (BMP) signalling pathway during the progression of pulmonary hypertension (PH) and discusses targeting of BMP signalling as a new...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP086041
更新日期:2017-09-01 00:00:00
abstract::To better understand the mechanisms underlying the pulmonary O(2) uptake (V(O(2P))) slow component during high-intensity exercise, we used (31)P magnetic resonance spectroscopy, gas exchange, surface electromyography and near-infrared spectroscopy measurements to examine the potential relationship between the slow com...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.062927
更新日期:2012-08-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? This article draws evidence from the current literature to support the hypothesis that non-coding RNA-mediated gene regulation takes place in the mitochondria. An emphasis is put on skeletal muscle. What advances does it highlight? This review highlights the potential role...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP086846
更新日期:2018-08-01 00:00:00
abstract::Transport of a number of dipolar amino acids (and the orally active antibiotic D-cycloserine) across the apical membrane of human intestinal epithelial (Caco-2) cell monolayers is mediated by a Na+-independent, pH-dependent transport mechanism. Relatively little is known about the mode of action of this transport syst...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Can low-dose inorganic nitrate supplementation prevent testicular structural and functional alterations in streptozotocin-induced type 1 diabetic male rats? What is the main finding and it's important? Treatment with a low dose of inorganic nitrate for 2 months h...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087198
更新日期:2018-12-01 00:00:00
abstract::Tumour cell survival is intimately related to blood vessel function and so the tumour vasculature represents a novel target for cancer therapy. We have investigated a murine tumour model in which a metal clamp was used to occlude the vascular supply temporarily and then removed to allow reperfusion. This allows the st...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.1997.sp004031
更新日期:1997-03-01 00:00:00
abstract::The effects of exogenous arginine vasotocin (AVT), isotocin (IT) and melatonin on the blood pressure of conscious Atlantic cod (Gadus morhua) were examined. Ventral aortic blood pressure (PVA) was recorded from a cannula inserted into the afferent branchial artery of the third gill arch. Dorsal aortic blood pressure (...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1998.sp004161
更新日期:1998-11-01 00:00:00
abstract::We present a curve-fitting approach that permits quantitative comparisons of fatigue profiles obtained with different stimulation protocols in isolated slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles of mice. Profiles from our usual stimulation protocol (125 Hz for 500 ms, evoked once every ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.041285
更新日期:2008-07-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Carotid artery longitudinal wall motion (CALM) is a bidirectional forward and backward motion of the arterial wall; however, there is no evidence in humans for what controls CALM despite proposals for pulse pressure, left ventricular motion and shear rate. What i...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086621
更新日期:2018-01-01 00:00:00
abstract::The role of endothelium in the decreased contraction to phenylephrine in aorta of pregnant Wistar rats has been studied. Contractions in response to phenylephrine were significantly decreased in aortic rings from pregnant rats compared to those from non-pregnant rats. Pretreatment of the rings with indomethacin did no...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1993.sp003694
更新日期:1993-05-01 00:00:00
abstract::What is the central question of this study? Failure to terminate apnoea and arouse is likely to contribute to sudden infant death syndrome (SIDS). Serotonin is deficient in the brainstems of babies who died of SIDS. Therefore, we tested the hypothesis that serotonin in the nucleus of the solitary tract (NTS) would sho...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085716
更新日期:2016-07-01 00:00:00
abstract::In this study we tested the hypothesis that, compared to young adult rats, senescent rats have a reduced ability to respond to muscle unloading. Unloading of the muscles was induced by hindlimb suspension (HS) of young adult and senescent rats for 21 days. Plantaris muscles from young adult rats had significantly high...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/eph8602235
更新日期:2001-07-01 00:00:00
abstract::This study presents a perfused preparation for evaluation of metabolism in pig intercostal muscle in vitro. Preserved vessels and nerves to an intercostal segment including two adjacent ribs allowed for tissue perfusion and electrical stimulation with measurement of contraction force, oxygen consumption and 31P-magnet...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.033274
更新日期:2006-07-01 00:00:00
abstract::Previously, we undertook simultaneous recording of ventilation and pulmonary gas exchange in mice and revealed that dopamine D(2) receptors participate in exercise hyperpnoea via behavioural control of ventilation with unchanged pulmonary gas exchange. Here, we examined the hypothesis that D(1) receptors also contribu...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.068312
更新日期:2013-02-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Can targeted ablation of cardiac sympathetic neurons suppress myocardial infarction-induced adverse cardiac remodelling and left ventricular dysfunction? What is the main finding and its importance? Targeted ablation of cardiac sympathetic neurons significantly a...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086928
更新日期:2018-09-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? I focus on clinical aspects of uterine physiology, specifically, myometrial contractility. I bring together and contrast findings using physiological approaches and those using newer techniques, 'omics'. What advances does it highlight? Physiological studies have recently ...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP085131
更新日期:2015-12-01 00:00:00
abstract::The inward transport of two purines, adenosine and hypoxanthine, at 37 degrees C by horse erythrocytes was compared. No mediated transport of adenosine was detected in horse erythrocytes, nor was saturable, high-affinity binding of the potent facilitated-diffusion inhibitor nitrobenzylthioinosine demonstrable in horse...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1998.sp004104
更新日期:1998-03-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Does the combination of methazolamide and theophylline reduce symptoms of acute mountain sickness (AMS) and improve aerobic performance in acute hypobaric hypoxia? What is the main finding and its importance? The oral combination of methazolamide (100 BID) and th...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088461
更新日期:2021-01-01 00:00:00
abstract::The effects of hypotonic solutions on intracellular Ca2+ were determined on primary cultures of human detrusor smooth muscle cells. In the presence of external Ca2+, changing from a solution containing 290 mosmol l-1 to one containing 240 mosmol l-1 (80% normal tonicity) activated a rise in intracellular Ca2+. If the ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1997.sp004056
更新日期:1997-07-01 00:00:00
abstract::Growing lambs fed a diet containing NaHCO3 were made acidotic by intravenously infusing HCl at the rate of 1 mmol/min over a 4 h period. Acid infusion led to a fall in blood and urine pH and a prompt increase in urinary Ca excretion. This in turn led to a fall in plasma Ca concentration and a rise in parathyroid hormo...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1993.sp003676
更新日期:1993-03-01 00:00:00
abstract::Neural activation decreases cerebral deoxyhaemoglobin (HHb(C)) and increases oxyhaemoglobin concentration (O(2)Hb(C)). In contrast, patients who present with restricted cerebral blood flow, such as those suffering from cerebral ischaemia or Alzheimer's disease, and during the course of ageing the converse occurs, in t...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.061978
更新日期:2012-02-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? We present a new non-invasive medical technology, the inspired sine-wave technique, which involves inhalation of sinusoidally fluctuating concentrations of a tracer gas. The technique requires only passive patient cooperation and can monitor different cardiorespi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086867
更新日期:2018-05-01 00:00:00
abstract::A great deal of knowledge exists regarding neural control of myocardial function in the rat. Most of the studies addressing this issue were conducted either under general anaesthesia or in isolated hearts in vitro. Our principal aim was to provide a detailed quantitative description of mechanisms controlling cardiac c...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.048710
更新日期:2010-01-01 00:00:00
abstract::In the present study, the ontogenic changes in gluconeogenic enzyme activities and in hepatic glycogen and beta-adrenergic receptor levels were investigated in fetal pigs from 70 days of gestation until delivery at term (114 +/- 2 days). The values were compared with those observed in fetuses infused subcutaneously wi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003860
更新日期:1995-05-01 00:00:00
abstract::It is unknown whether changes in corticomotor excitability follow prolonged exercise in healthy humans. Furthermore, the role of supraspinal fatigue in decrements of force production and voluntary activation following prolonged exercise has not been established. This study investigated peripheral and central fatigue a...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.035972
更新日期:2007-03-01 00:00:00
abstract::The aims of this study were: (1) to determine the within-subject, between-day variability in end-tidal P(CO2) (P(ET,CO2)); (2) to determine whether the within-subject, between-day variability in P(ET,CO2) was caused by variations in metabolic acid-base status; and (3) to determine whether between-subject variations in...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:10.1113/eph8802585
更新日期:2003-09-01 00:00:00
abstract::This study examined the effect of pre-exercise carbohydrate (CHO) ingestion on pyruvate dehydrogenase complex (PDC) activation, acetyl group availability and substrate level phosphorylation (glycogenolysis and phosphocreatine (PCr) hydrolysis) in human skeletal muscle during the transition from rest to steady-state ex...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::What is the central question of this study? Neurocognitive functions can be enhanced by acute aerobic exercise, which could be associated with changes in serum brain-derived neurotrophic factor (BDNF) concentrations. We aimed to explore acute exercise-induced changes in BDNF concentrations, neuropsychological and neur...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085682
更新日期:2016-07-01 00:00:00
abstract::Previous studies have shown that prolactin administration to pregnant rats results in offspring with enhanced abundance of the brown adipose tissue-specific uncoupling protein (UCP) 1. The present study therefore aimed to determine whether a similar effect was observed after birth and if the sex of the animal further ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/eph8802575
更新日期:2003-07-01 00:00:00
abstract::The autonomic adjustments to exercise are mediated by central signals from the higher brain (central command) and by a peripheral reflex arising from working skeletal muscle (exercise pressor reflex), with further modulation provided by the arterial baroreflex. Although it is clear that central command, the exercise p...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2005.032037
更新日期:2006-01-01 00:00:00