Nuclear accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokers.

abstract：:The efficacy of continuous positive airway pressure (CPAP) administered with a face mask was compared to oxygen supplementation in 40 patients with acute cardiogenic pulmonary edema. Baseline arterial blood gas values and pH, heart rate, respiratory rate, and blood pressure were recorded after patients breathed 28 per...

journal_title：Chest

authors： Väisänen IT,Räsänen J

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND:National spirometric surveillance data in the United States were last collected during 1988-1994. The objective of this study was to provide current estimates for obstructive and restrictive impairment of lung function and to examine changes since 1988-1994. METHODS:We used data from 14,360 participants age...

journal_title：Chest

authors： Ford ES,Mannino DM,Wheaton AG,Giles WH,Presley-Cantrell L,Croft JB

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Studies have demonstrated that high-flow nasal cannula (HFNC) prevents intubation in acute hypoxic respiratory failure when compared with conventional oxygen therapy (COT). However, the data examining routine HFNC use in the immediate postoperative period are less clear. RESEARCH QUESTION:Is routine HFNC us...

journal_title：Chest

authors： Chaudhuri D,Granton D,Wang DX,Burns KEA,Helviz Y,Einav S,Trivedi V,Mauri T,Ricard JD,Mancebo J,Frat JP,Jog S,Hernandez G,Maggiore SM,Mbuagbaw L,Hodgson CL,Jaber S,Goligher EC,Brochard L,Rochwerg B

更新日期：2020-11-01 00:00:00

abstract：:A 33-year-old man with a two-year history of asthma and sinusitis presented with wheezing, pleuritis, bilateral pleural effusions, and patchy basilar infiltrates on chest roentgenogram. Laboratory studies revealed peripheral blood eosinophilia, and pulmonary function studies showed an obstructive pattern which was bro...

journal_title：Chest

authors： Erzurum SC,Underwood GA,Hamilos DL,Waldron JA

更新日期：1989-06-01 00:00:00

abstract：:beta 2-agonist bronchodilators delivered by metered-dose inhalers (MDI) are commonly used in the treatment of bronchospasm in both intubated and nonintubated patients. Substantial data support the effectiveness of MDI delivery systems in nonintubated patients. However, few studies have examined the effectiveness of MD...

journal_title：Chest

authors： Manthous CA,Chatila W,Schmidt GA,Hall JB

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Productivity loss is an overlooked aspect of the burden of chronic health conditions. While modern guidelines emphasize achieving clinical control in asthma management, few studies have reported on the relationship between asthma control and productivity loss. We calculated the productivity loss that can be ...

journal_title：Chest

authors： Sadatsafavi M,Rousseau R,Chen W,Zhang W,Lynd L,FitzGerald JM

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The accuracy of combined clinical examination (CE) and chest radiography (CXR) (CE + CXR) vs thoracic ultrasonography in the acute assessment of pneumothorax, hemothorax, and lung contusion in chest trauma patients is unknown. METHODS:We conducted a prospective, observational cohort study involving 119 adul...

journal_title：Chest

authors： Hyacinthe AC,Broux C,Francony G,Genty C,Bouzat P,Jacquot C,Albaladejo P,Ferretti GR,Bosson JL,Payen JF

更新日期：2012-05-01 00:00:00

abstract：:Cidofovir, a nucleoside analog antiviral agent, has been used with moderate success in the treatment of juvenile laryngeal papillomatosis (JLP) by direct intralesional injection. We report the first case where IV cidofovir was used successfully to treat a rare but lethal multicystic lung disease complicating JLP. A 35...

journal_title：Chest

authors： Dancey DR,Chamberlain DW,Krajden M,Palefsky J,Alberti PW,Downey GP

更新日期：2000-10-01 00:00:00

abstract：:Auditors in Medicare overpayment or False Claims Act (FCA) cases often use statistical extrapolation to estimate a health-care provider's total liability from a small sample of audited claims. Courts treat statistical extrapolation differently depending on the context. They generally afford the government substantial ...

journal_title：Chest

authors： Salcido R,Rubin E

更新日期：2016-06-01 00:00:00

abstract：:A 53-year-old man with tracheobronchomalacia had two stents placed in his airways to maintain patency. He ingested one of the tracheal stents that was inadvertently dislodged during a brief coughing episode. The swallowed stent was recovered without complications. ...

journal_title：Chest

authors： Mattison LE,Frye MD,Collop NA

更新日期：1995-09-01 00:00:00

abstract：:To investigate the influence of resting pulmonary mechanics on the pattern of breathing during exercise in chronic obstructive pulmonary disease (COPD), we studied 29 patients with moderate to severe COPD (FEV1 50 +/- 20 percent predicted), and 10 normal subjects. Lung mechanics were studied using esophageal balloon t...

journal_title：Chest

authors： Marin JM,Hussain SN,Gibbons WJ,Polverino M,Levy RD,Cosio MG

更新日期：1993-09-01 00:00:00

abstract：:Two patients are described who had congestive heart failure with loculated interlobar air-fluid collections. Although pseudotumor (interlobar effusion) is a well-known finding in congestive heart failure, the additional presence of air is unique. Both are somewhat related to the underlying failure. ...

journal_title：Chest

authors： Rabinowitz JG,Kongtawng T

更新日期：1978-12-01 00:00:00

abstract：:A case of disseminated histoplasmosis followed later by disseminated coccidioidomycosis is described. The clinical illness and immunologic studies suggest subtle defects that may have existed antecedent to infection and, thus, provided an opportunity for widespread dissemination by these normally nonopportunistic orga...

journal_title：Chest

authors： Kaplan P,Graybill JR,Thor D

更新日期：1977-08-01 00:00:00

abstract：:Forty-three consecutive patients requiring endotracheal intubation in an emergency room were studied prospectively to define the complications associated with intubation and the survival of these patients, and to evaluate emergency room policies. The indications for intubation were acute respiratory failure (ARF) in 2...

journal_title：Chest

authors： Taryle DA,Chandler JE,Good JT Jr,Potts DE,Sahn SA

更新日期：1979-05-01 00:00:00

abstract：:Acute chest syndrome complicating sickle cell anemia may progress to adult respiratory distress syndrome despite appropriate therapy. Extra-alveolar air leaks may complicate the care of these patients as conventional mechanical ventilation becomes increasingly difficult. We successfully treated a child with sickle cel...

journal_title：Chest

authors： Baird JS,Johnson JL,Escudero J,Powars DR

更新日期：1994-12-01 00:00:00

abstract：STUDY OBJECTIVES:To investigate whether oxidative stress occurs following lobectomy and pneumonectomy and to evaluate whether markers of oxidative stress might be of value in the assessment of the diagnosis, course, and prognosis of postoperative complications. DESIGN:A prospective study. SETTING:A specialized thorac...

journal_title：Chest

authors： Lases EC,Duurkens VA,Gerritsen WB,Haas FJ

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:FEV1 may remain stable while high-resolution CT (HRCT) appearances deteriorate in children with cystic fibrosis (CF). However, spirometry results commonly decline in older age groups. OBJECTIVES:To compare the rate of decline in HRCT abnormalities and spirometry results over time in an adult cohort with CF....

journal_title：Chest

authors： Judge EP,Dodd JD,Masterson JB,Gallagher CG

更新日期：2006-11-01 00:00:00

abstract：:There is a small population of peripheral T cells bearing the gamma delta T-cell receptor, which may be involved in the defense against invading microorganisms and tumor cells. The present study was designed to evaluate the levels of gamma delta T cells in patients with pulmonary tuberculosis, bacterial pneumonia, chr...

journal_title：Chest

authors： Ito M,Kojiro N,Ikeda T,Ito T,Funada J,Kokubu T

更新日期：1992-07-01 00:00:00

abstract：:The hemodynamic effects of a new orally active vasodilator, flosequinan, were compared with placebo (single blind) over 24 h in eight patients with pulmonary hypertension secondary to severe chronic obstructive pulmonary disease. Mean pulmonary artery pressure was reduced by 5.1 (3.4, 6.7) mm Hg (mean 95 percent CI) (...

journal_title：Chest

authors： Elborn JS,Richardson G,Murphy P,MacMahon J

更新日期：1992-10-01 00:00:00

abstract：:In a double-blind study the fiberoptic bronchoscope was contaminated with five pathogenic organisms, each at a concentration of 10(9) organisms per milliliter. The shaft and inner channel of the bronchoscope were cleansed with five antiseptic regimens. Each regimen included equal 120-ml aliquots of one, two, or three ...

journal_title：Chest

authors： Donaldson JC,Stoop DR,Williams SA

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:The occurrence of catamenial pneumothorax (CP) is rare, and the awareness of this diagnosis among physicians is insufficient. CP is highly correlated with pelvic endometriosis and remains the most common form of thoracic endometriosis syndrome. Circulating endometrial cells (CECs) have been previously detect...

journal_title：Chest

authors： Kiss I,Pospisilova E,Kolostova K,Maly V,Stanek I,Lischke R,Schutzner J,Pawlak I,Bobek V

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To assess the incidence of pseudomonal infection, colonization, and inflammation in the allograft of lung transplant recipients with cystic fibrosis (CF) as compared with recipients with other end-stage lung disease. DESIGN:Retrospective review. SETTING:University medical center transplant service. PATIENT...

journal_title：Chest

authors： Nunley DR,Grgurich W,Iacono AT,Yousem S,Ohori NP,Keenan RJ,Dauber JH

更新日期：1998-05-01 00:00:00

abstract：:Plug closure of patent ductus arteriosus without thoracotomy is reliable and can be a good alternative to surgical closure for selected patients. We report our experiences with plug closure in 87 consecutive patients (age range, 3 to 38 years). Closure was successful in 83 patients (95 percent). There has been no mort...

journal_title：Chest

authors： Kitamura S,Sato K,Naito Y,Shimizu Y,Fujino M

更新日期：1976-11-01 00:00:00

abstract：:Epidemiologic research has revealed a substantial portion of the general population with abnormal spirometry results that are characterized by decreased FEV1 and FVC but a preserved FEV1/FVC ratio. This restrictive spirometry pattern (RSP) is inconsistently defined in the literature and not well addressed by current g...

journal_title：Chest

authors： Godfrey MS,Jankowich MD

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Acquired somatic mutations induced by oxidative stress may contribute to the molecular pathogenesis of chronic inflammatory airway diseases. The objective of this study was to assess the intensity of oxidative DNA damage and the presence of microsatellite DNA instability (MSI), a marker of acquired somatic m...

journal_title：Chest

authors： Tzortzaki EG,Dimakou K,Neofytou E,Tsikritsaki K,Samara K,Avgousti M,Amargianitakis V,Gousiou A,Menikou S,Siafakas NM

更新日期：2012-05-01 00:00:00

abstract：:To assess the value of bronchoalveolar lavage (BAL) for diagnosis, understanding, and treatment of amiodarone-associated pneumonitis, we examined the results of BAL total and differential cell counts and phenotyping of lymphocytes in 22 patients with this lung disorder and in 33 normal subjects. Overall, the total cel...

journal_title：Chest

authors： Akoun GM,Cadranel JL,Blanchette G,Milleron BJ,Mayaud CM

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of repeated thoracenteses on the fluid characteristics and the levels of various cytokines, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-5, IL-6, and IL-8, and of plasminogen activator inhibitor type 1 (PAI-1) and tissue type plasminogen activator in malignant...

journal_title：Chest

authors： Chung CL,Chen YC,Chang SC

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:In recent years, the population of patients with pulmonary arterial hypertension (PAH) has changed dramatically, including more advanced age at diagnosis. We hypothesized that older patients have a distinct clinical profile with different disease characteristics and response to intervention. METHODS:All pre...

journal_title：Chest

authors： Rose JA,Cleveland JM,Rao Y,Minai OA,Tonelli AR

更新日期：2016-05-01 00:00:00

abstract：:From 1982 to 1989, ECD was performed on 18 patients suffering from poorly-tolerated massive pulmonary embolism, for whom classic treatments (fibrinolytics and surgery) were impossible. Eleven of these 18 patients immediately improved (S group). This procedure was unsuccessful in other seven patients (F group). Thirtee...

journal_title：Chest

authors： Timsit JF,Reynaud P,Meyer G,Sors H

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Histopathologic evidence of fibrosis on surgical lung biopsy has been associated with reduced survival in patients with hypersensitivity pneumonitis (HP). Changes of pulmonary fibrosis detected on CT may also correlate with prognosis in patients with HP. METHODS:We identified 69 consecutive patients with HP...

journal_title：Chest

authors： Hanak V,Golbin JM,Hartman TE,Ryu JH

更新日期：2008-07-01 00:00:00