Circulating Endometrial Cells in Women With Spontaneous Pneumothorax.

Abstract:

BACKGROUND:The occurrence of catamenial pneumothorax (CP) is rare, and the awareness of this diagnosis among physicians is insufficient. CP is highly correlated with pelvic endometriosis and remains the most common form of thoracic endometriosis syndrome. Circulating endometrial cells (CECs) have been previously detected in patients with pelvic endometriosis. Could CECs bring new insights into pneumothorax management? METHODS:This study aims to describe the occurrence and molecular characteristics of CECs in women with spontaneous pneumothorax (SP) (N = 20) with high suspicion of its catamenial character. CECs were enriched from peripheral blood by size-based separation (MetaCell). In addition to cytomorphology, gene expression profiling of captured cells was performed for 24 endometriosis-associated genes. RESULTS:CECs were present in all 20 patients with SP. Enriched CECs exhibited four character features: epithelial, stem cell-like, stroma-like, and glandular. However, not all of them were present in every sampling. Gene expression profiling revealed two distinct phenotypes of CECs in SP and/or CP: one of them refers to the diaphragm openings syndrome and the other to endometrial tissue pleural implantations. Comparisons of the gene expression profiles of CECs in pneumothorax (CECs-SP group) with CECs in pelvic endometriosis (CECs-non-SP group) have revealed significantly higher expression of HER2 in the CECs-SP group compared with the CECs-non-SP group. CONCLUSIONS:This proof-of-concept study demonstrates successful isolation and characterization of CECs in patients with SP. Identification of CECs in SP could alert endometriosis involvement and help early referral to gynecologic consultation for further examination and treatment.

journal_name

Chest

journal_title

Chest

authors

Kiss I,Pospisilova E,Kolostova K,Maly V,Stanek I,Lischke R,Schutzner J,Pawlak I,Bobek V

doi

10.1016/j.chest.2019.09.008

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

342-355

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(19)33873-5

journal_volume

157

pub_type

杂志文章

相关文献

CHEST文献大全
  • Genetics of asthma and COPD. Similar results for different phenotypes.

    abstract::Asthma and COPD are common respiratory diseases that are caused by the interaction of genetic susceptibility with environmental factors. Environmental influences are important in both diseases, and although there are differences in genetic susceptibilities, there are also similarities. Three examples of interest for b...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.126.2_suppl_1.105S

    authors: Meyers DA,Larj MJ,Lange L

    更新日期:2004-08-01 00:00:00

  • Pulmonary complications in lead miners.

    abstract::We carried out a study to assess the prevalence of respiratory disease in lead miners and to investigate the roles of silica and lead. We used a questionnaire for symptoms and examinations for signs of respiratory disease, chest roentgenograms, and spirometric study in 45 lead miners. Six underwent bronchoscopy and tr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.96.1.18

    authors: Masjedi MR,Estineh N,Bahadori M,Alavi M,Sprince NL

    更新日期:1989-07-01 00:00:00

  • Pulmonary embolism among patients with a nearly normal ventilation/perfusion lung scan.

    abstract:BACKGROUND:Among patients with nearly normal ventilation/perfusion (V/Q) lung scans in the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED), pulmonary embolism (PE) was diagnosed more frequently in those who underwent pulmonary angiography than in those in whom PE was diagnosed on the basis of an adve...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.110.2.395

    authors: Henry JW,Stein PD,Gottschalk A,Raskob GE

    更新日期:1996-08-01 00:00:00

  • Reperfusion adequacy and functional recovery.

    abstract::Ischemic myocardium undergoes many physiologic changes, including alterations in contractile function, histologic condition, and oxygen utilization. Reperfusion of ischemic myocardium may reverse some of these changes; however, the level of reperfusion needed for adequate functional recovery, as opposed to myocyte sal...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.112.4.1075

    authors: Rohs TJ Jr,Benedict MB,Bolling SF

    更新日期:1997-10-01 00:00:00

  • A comparison of albuterol administered by metered-dose inhaler and spacer with albuterol by nebulizer in adults presenting to an urban emergency department with acute asthma.

    abstract:STUDY OBJECTIVES:To determine the efficacy of albuterol by metered-dose inhaler (MDI) and spacer compared to a nebulizer. DESIGN:A prospective, open-label study. SETTING:Large urban emergency department (ED). PATIENTS:All consecutive adult asthma patients over a 2.5-year period. INTERVENTIONS:ED personnel used a st...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.121.4.1036

    authors: Newman KB,Milne S,Hamilton C,Hall K

    更新日期:2002-04-01 00:00:00

  • Thrombolysis with tissue plasminogen activator in suspected acute myocardial infarction. The ASSET Study.

    abstract::Intravenous rtPA (total dose, 100 mg over 3 h) was compared with placebo in a prospective, randomized, double-blind trial in 5,011 patients with suspected AMI of less than 5 h duration. No ECG or enzymatic confirmation of the diagnosis was required for study entry. At 1 month 9.8% of patients given placebo had died co...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Wilcox RG

    更新日期:1989-05-01 00:00:00

  • Psychosocial issues in the assessment and management of patients undergoing lung transplantation.

    abstract::This review examines psychosocial issues among lung transplant patients from the time of assessment through the posttransplant period. Although psychological factors are recognized as being important in the transplant evaluation, no standard approach to psychological assessment currently exists. Lung transplant candid...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.129.5.1367

    authors: Barbour KA,Blumenthal JA,Palmer SM

    更新日期:2006-05-01 00:00:00

  • Accuracy of BAL galactomannan in diagnosing invasive aspergillosis: a bivariate metaanalysis and systematic review.

    abstract:BACKGROUND:A serum galactomannan (GM) assay has been approved for diagnosing invasive aspergillosis (IA). However, the role of the BAL-GM assay has not been well established. Therefore, we conducted a metaanalysis to determine the overall accuracy of BAL-GM in the diagnosis of IA. METHODS:After a systematic review of ...

    journal_title:Chest

    pub_type: 杂志文章,meta分析

    doi:10.1378/chest.10-0488

    authors: Guo YL,Chen YQ,Wang K,Qin SM,Wu C,Kong JL

    更新日期:2010-10-01 00:00:00

  • A Blueprint for Success: Design and Implementation of an Ideal Bronchoscopy Suite.

    abstract::Bronchoscopy is essential to the practice of pulmonary medicine. It is an important diagnostic and therapeutic tool for many disease processes. Bronchoscopy can be performed in a variety of clinical settings, from the bedside to an operating room. Although bronchoscopy has been practiced for more than a century, conse...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2019.09.024

    authors: Mehta AC,Avasarala SK,Jain P,Deshwal H,Gildea TR

    更新日期:2020-03-01 00:00:00

  • Is sick sinus syndrome an adenosine-mediated disease? Effects of intravenous aminophylline on sick sinus node function after pharmacologic autonomic blockade.

    abstract::To assess the effects of intravenous aminophylline on the sinus node, 12 patients with clinical and Holter monitor-documented sick sinus syndrome were studied (1) during the control state, (2) after pharmacologic autonomic blockade and (3) 5 min after intravenous administration of aminophylline. The effects of aminoph...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.4.887

    authors: Lai WT,Lai HM,Lin CT,Sheu SH,Hwang YS

    更新日期:1991-04-01 00:00:00

  • Host factors affecting longitudinal decline in lung spirometry among grain elevator workers.

    abstract::The host factors affecting the longitudinal decline in lung function among 267 white male grain elevator workers who were still working in the industry and did not change their smoking habits over a period of six years were studied. Spirometric measures declined more rapidly in older grain handlers as compared with yo...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.85.6.782

    authors: Tabona M,Chan-Yeung M,Enarson D,MacLean L,Dorken E,Schulzer M

    更新日期:1984-06-01 00:00:00

  • Measurement of dynamic hyperinflation after a 6-minute walk test in patients with COPD.

    abstract:BACKGROUND:Dynamic hyperinflation (DH) develops in patients with COPD during incremental exercise with a cycle ergometer. The aims of this study were to determine whether DH can be evidenced after walking with a handheld spirometer and to determine its functional consequences. METHODS:Fifty patients with COPD (39 men;...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.09-0410

    authors: Callens E,Graba S,Gillet-Juvin K,Essalhi M,Bidaud-Chevalier B,Peiffer C,Mahut B,Delclaux C

    更新日期:2009-12-01 00:00:00

  • Alternative therapies among adults with a reported diagnosis of asthma or rhinosinusitis : data from a population-based survey.

    abstract:BACKGROUND:Asthma and rhinosinusitis are common medical conditions among adults. Alternative treatments could have important impacts on health status among those individuals with these conditions, but specific prevalence data for these treatments are limited. OBJECTIVE:To estimate the prevalence of specific alternativ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.120.5.1461

    authors: Blanc PD,Trupin L,Earnest G,Katz PP,Yelin EH,Eisner MD

    更新日期:2001-11-01 00:00:00

  • Sensitivity and Safety of Electromagnetic Navigation Bronchoscopy for Lung Cancer Diagnosis: Systematic Review and Meta-analysis.

    abstract:BACKGROUND:Bronchoscopy is a useful tool for the diagnosis of lesions near central airways; however, the diagnostic accuracy of these procedures for peripheral pulmonary lesions (PPLs) is a matter of ongoing debate. In this setting, electromagnetic navigation bronchoscopy (ENB) is a technique used to navigate and obtai...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2020.05.534

    authors: Folch EE,Labarca G,Ospina-Delgado D,Kheir F,Majid A,Khandhar SJ,Mehta HJ,Jantz MA,Fernandez-Bussy S

    更新日期:2020-10-01 00:00:00

  • Proinflammatory cytokines and fibrinolytic enzymes in tuberculous and malignant pleural effusions.

    abstract:OBJECTIVES:To measure tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in pleural effusions caused by tuberculosis (TB) and malignancy and their relationship with plasminogen activator inhibitor type I (PAI-1) and tissue type plasminogen activator (tPA), and to compare the differences between tu...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.5.1292

    authors: Hua CC,Chang LC,Chen YC,Chang SC

    更新日期:1999-11-01 00:00:00

  • Changes in BP induced by passive leg raising predict response to fluid loading in critically ill patients.

    abstract:OBJECTIVE:To test the hypothesis that passive leg raising (PLR) induces changes in arterial pulse pressure that can help to predict the response to rapid fluid loading (RFL) in patients with acute circulatory failure who are receiving mechanical ventilation. DESIGN:Prospective clinical study. SETTING:Two medical ICUs...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.121.4.1245

    authors: Boulain T,Achard JM,Teboul JL,Richard C,Perrotin D,Ginies G

    更新日期:2002-04-01 00:00:00

  • AIDS, public policy and biomedical research.

    abstract::The current epidemic of acquired immune deficiency syndrome (AIDS) raises numerous public policy concerns for the medical community. The issues can be divided into two groups. Those concerns which require both immediate action and results are referred to as short-term issues. Those issues whose results will not be for...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.85.3.416

    authors: Panem S

    更新日期:1984-03-01 00:00:00

  • Living cytology: A new diagnostic technique for malignant pleural effusions.

    abstract::The efficacy of a new tissue-culture technique for the diagnosis of malignant pleural effusions was contrasted with conventional cytologic methods. The new technique is based on the ability of the tissue-culture medium to transform mesothelial cells into fibroblasts while not sustaining lymphoreticular cells. Against ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.69.5.626

    authors: Monif GR,Stewart BN,Block AJ

    更新日期:1976-05-01 00:00:00

  • Peak expiratory flow with or without a brief postinspiratory pause.

    abstract:BACKGROUND:The duration of postinspiratory pause prior to forced expiration may significantly influence the peak expiratory flow (PEF) measured during maximal forceful expirations. In comparison with maneuvers without a postinspiratory pause, maneuvers with 4 to 6-s pause at total lung capacity (TLC) result in decrease...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.1.442

    authors: Omar T,Alawadhi H,Soubani AO,Tzelepis GE

    更新日期:2005-07-01 00:00:00

  • Assessment and diagnosis of renal dysfunction in the ICU.

    abstract::Identifying patients with impaired renal function is crucial in the setting of critical illness. Serum creatinine serves as the gold standard for assessing steady-state renal function, helping to define those with chronic kidney disease (CKD). Although these baseline creatinine values are often not available in the se...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.11-1513

    authors: Koyner JL

    更新日期:2012-06-01 00:00:00

  • Prediction of PaO2 during treadmill walking in patients with COPD.

    abstract::We studied the possibility of predicting PaO2 during exercise of a given oxygen uptake (VO2) from resting pulmonary function tests (PFTs) in patients with chronic obstructive pulmonary disease (COPD). The three-minute incremental treadmill exercise was performed with serial measurements of PaO2 via intra-arterial cath...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.91.3.328

    authors: Kurihara N,Fujimoto S,Terakawa K,Yamamoto M,Takeda T

    更新日期:1987-03-01 00:00:00

  • Small- and moderate-size right-to-left shunts identified by saline contrast echocardiography are normal and unrelated to migraine headache.

    abstract:BACKGROUND:We suspected, based on clinical experience, that the prevalence of both intracardiac and pulmonary arteriovenous malformations (PAVMs) is higher than previously reported in a healthy population when using modern ultrasound technology combined with a rigorous saline contrast echocardiogram (SCE) protocol. We ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.09-2797

    authors: Woods TD,Harmann L,Purath T,Ramamurthy S,Subramanian S,Jackson S,Tarima S

    更新日期:2010-08-01 00:00:00

  • Bronchoscopic protected catheter brush for the diagnosis of pulmonary infections.

    abstract::A new bronchoscopic-protected catheter brush (BPCB), designed to obtain uncontaminated bronchial secretions, was studied in vitro and in vivo. The device was composed of a standard biopsy brush, protected by a single catheter and occluded with an agar plug. Ejection of the plug was obtained neither by advancing the br...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.93.4.746

    authors: Marquette CH,Ramon P,Courcol R,Wallaert B,Tonnel AB,Voisin C

    更新日期:1988-04-01 00:00:00

  • Ischemia and reperfusion during intermittent coronary occlusion in man. Studies of electrocardiographic changes and CPK release.

    abstract::The course of 357 balloon inflations performed during 38 angioplasties for single-vessel coronary artery disease was prospectively studied using continuous ECG recording. Ischemic ECG changes appeared during 91 percent of the inflations at a mean of 20 +/- 8 seconds after inflation and resolved in 97 percent of those ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.2.386

    authors: Mager A,Sclarovsky S,Wurtzel M,Menkes H,Strasberg B,Rechavia E

    更新日期:1991-02-01 00:00:00

  • The relationship between left ventricular function assessed by multigated radionuclide test and cardiopulmonary exercise test in patients with ischemic heart disease.

    abstract:STUDY OBJECTIVES:To compare the oxygen pulse curve (O(2)P-C) as measured during cardiopulmonary exercise testing (CPET) with left ventricular (LV) ejection fraction (LVEF) rest-exercise response as measured by multigated equilibrium (99m)Tc radionuclide cineangiography (MUGA) in patients with different degrees of ische...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.121.3.841

    authors: Klainman E,Fink G,Lebzelter J,Krelbaumm T,Kramer MR

    更新日期:2002-03-01 00:00:00

  • Frequency spectra of normal breath sounds in childhood.

    abstract::Clinicians who auscultate the chest of normal children note that the frequency content of their breath sounds appears to vary with age. Because these changes have not been systematically documented before, we recorded and analyzed inspiratory breath sounds in 35 children (0 to 13 years) and five adults (34 to 43 years...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.4.999

    authors: Hidalgo HA,Wegmann MJ,Waring WW

    更新日期:1991-10-01 00:00:00

  • Diagnosis of tracheal injury in mechanically ventilated premature infants by flexible bronchoscopy. A pilot study.

    abstract::Flexible bronchoscopy (FB) is uniquely suited for the study of large airway lesions in the ventilated premature infant. However, no standardized clinical scoring system of distal tracheal injury exists and the adverse consequences of FB in ventilated premature infants are not well described. Using a prototype Olympus ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.98.5.1219

    authors: Schellhase DE,Graham LM,Fix EJ,Sparks LM,Fan LL

    更新日期:1990-11-01 00:00:00

  • Left atrial myxoma and acute myocardial infarction. A dangerous duo in the thrombolytic agent era.

    abstract::Systemic embolization is a common complication of left atrial myxoma; however, coronary embolism leading to acute myocardial infarction is rare. The use of echocardiography has increased the detection of intracardiac tumors when signs and symptoms are not evident. Echocardiography is the diagnostic procedure of choice...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.109.4.1106

    authors: Abascal VM,Kasznica J,Aldea G,Davidoff R

    更新日期:1996-04-01 00:00:00

  • Anomalous pulmonary venous pathway traversing pulmonary parenchyma. Diagnosis and implication.

    abstract:STUDY OBJECTIVES:To describe four patients having total anomalous pulmonary venous connection with an intrapulmonary vertical vein, rendering difficulty in diagnosis and surgery. SETTING:a tertiary referral center. PATIENTS AND METHODS:By reviewing medical records, 4 of 25 patients with right atrial isomerism and tot...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.110.5.1363

    authors: Wang JK,Chiu IS,How SW,Wu MH,Wu FF,Hung CR,Lue HC

    更新日期:1996-11-01 00:00:00

  • Renal and vascular effects of atrial natriuretic factor during cardiopulmonary bypass.

    abstract:STUDY OBJECTIVE:To evaluate renal and vasodilator effects of synthetic atrial natriuretic factor (ANF) in patients undergoing cardiopulmonary bypass (CPB) with special reference to the applicability of ANF as a diuretic and natriuretic. DESIGN:The study consisted of two parts. The first 15 consecutive patients in a un...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.100.5.1203

    authors: Hynynen M,Palojoki R,Heinonen J,Tikkanen I,Harjula AL,Fyhrquist F

    更新日期:1991-11-01 00:00:00