Cancer epidemiology in populations of the United States--with emphasis on Hawaii and California--and Japan.

abstract：:Integrin alpha(5)beta(1) is overexpressed on endothelial cells of tumor vessels and is uniformly and rapidly accessible to antibodies in the bloodstream. Here, we determined whether antibodies rapidly gain access to integrin overexpressed on the abluminal (basolateral) surface of endothelial cells through vascular lea...

journal_title：Cancer research

authors： Magnussen A,Kasman IM,Norberg S,Baluk P,Murray R,McDonald DM

更新日期：2005-04-01 00:00:00

abstract：:We used three techniques to examine excision repair in human cells treated with ultraviolet radiation, N-acetoxy-2-acetylaminofluorene, and a combination of the two. The three techniques gave similar results. Two types of human cells were used: (a) excision repair proficient (normal human fibroblasts and xeroderma pig...

journal_title：Cancer research

authors： Ahmed FE,Setlow RB

更新日期：1979-02-01 00:00:00

abstract：:The study by Jaratlerdsiri and colleagues represents the first whole-genome sequencing study of prostate cancer from men in sub-Saharan Africa. Preliminary findings include a higher tumor mutation burden in these tumors compared with data from other available prostate cancer cohorts. Although larger studies are needed...

journal_title：Cancer research

authors： Huang FW

更新日期：2018-12-15 00:00:00

abstract：:The human breast cancer (Br-10) serially transplanted to nude mice (BALB/c-nu/nu) grew well in female mice but very slowly or not at all in untreated male mice and female mice treated with 1 mg of testosterone i.m. twice a week. The growth in female mice was arrested by ovariectomy, and that in male mice was accelerat...

journal_title：Cancer research

authors： Hirohashi S,Shimosato Y,Kameya T,Nagai K,Tsunematsu R

更新日期：1977-09-01 00:00:00

abstract：:Activation of the PI3K pathway occurs commonly in a wide variety of cancers. Experience with other successful targeted agents suggests that clinical resistance is likely to arise and may reduce the durability of clinical benefit. Here, we sought to understand mechanisms underlying resistance to PI3K inhibition in PTEN...

journal_title：Cancer research

authors： Nakanishi Y,Walter K,Spoerke JM,O'Brien C,Huw LY,Hampton GM,Lackner MR

更新日期：2016-03-01 00:00:00

abstract：:Aniline of unknown purity has been reported to induce spleen hemangiosarcoma in rats. Aniline has been found to be negative in terms of mutagenicity in both bacteria and yeasts. We have found that both commercial (already rather pure) and repurified aniline are clearly positive to a similar extent in inducing DNA dama...

journal_title：Cancer research

authors： Parodi S,Pala M,Russo P,Zunino A,Balbi C,Albini A,Valerio F,Cimberle MR,Santi L

更新日期：1982-06-01 00:00:00

abstract：:Alteration in epidermal growth factor receptor (EGFR) expression is frequently associated with malignant transformation of epithelial tissues, including oral mucosa. This study examines the mutations in the coding region of the human EGFR gene in normal and malignant human oral keratinocytes. To examine the intragenic...

journal_title：Cancer research

authors： Shintani S,Matsuo K,Crohin CC,McBride J,Tsuji T,Donoff RB,Posner M,Todd R,Wong DT

更新日期：1999-08-15 00:00:00

abstract：:Recent investigations have documented that constitutively activated phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling is a common feature of T-cell acute lymphoblastic leukemia (T-ALL), where it strongly influences growth and survival. These findings lend compelling weight for the...

journal_title：Cancer research

authors： Chiarini F,Falà F,Tazzari PL,Ricci F,Astolfi A,Pession A,Pagliaro P,McCubrey JA,Martelli AM

更新日期：2009-04-15 00:00:00

abstract：:The ability of culture dishes coated with an extracellular matrix (ECM) to act as a suitable substrate for human ovarian carcinoma cells in vitro has been examined. The plating efficiency on ECM was 30 to 80% (dispersed tumor cells from solid tumor tissue and effusions) with active proliferation of tumor cells being o...

journal_title：Cancer research

authors： Crickard K,Crickard U,Yoonessi M

更新日期：1983-06-01 00:00:00

abstract：:It is currently widely accepted that genetic instability is key to cancer development. Many types of cancers arise as a consequence of a gradual accumulation of nucleotide aberrations, each mutation conferring growth and/or survival advantage. Genetic instability could also proceed in sudden bursts leading to a more d...

journal_title：Cancer research

authors： Bavoux C,Leopoldino AM,Bergoglio V,O-Wang J,Ogi T,Bieth A,Judde JG,Pena SD,Poupon MF,Helleday T,Tagawa M,Machado C,Hoffmann JS,Cazaux C

更新日期：2005-01-01 00:00:00

abstract：:This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RB itself and p107. After a brief analysis of the established structural and functional similarities among the three genes, the main purp...

journal_title：Cancer research

authors： Paggi MG,Giordano A

更新日期：2001-06-15 00:00:00

abstract：:Measurements of respiration, CO2 and lactate production, and changes in the levels of various key metabolites of the glycolytic sequence and tricarboxylic acid cycle were made on five lines of rodent ascites tumor cells (two strains of Ehrlich ascites tumor cells, Krebs II carcinoma, AS-30D carcinoma, and L1210 cells)...

journal_title：Cancer research

authors： Greenhouse WV,Lehninger AL

更新日期：1977-11-01 00:00:00

abstract：:The induction, accumulation, and persistence of sister chromatid exchanges (SCEs) and high SCE frequency cells (HFCs) was measured in peripheral blood lymphocytes of women with breast cancer before chemotherapy and on multiple occasions during and after therapy. Chemotherapy consisted of i.v. infusion of cyclophospham...

journal_title：Cancer research

authors： Tucker JD,Wyrobek AJ,Ashworth LK,Christensen ML,Burton GV,Carrano AV,Everson RB

更新日期：1990-08-15 00:00:00

abstract：:The production of CD73-derived adenosine (Ado) by Tregs has been proposed as a resistance mechanism to anti-PD-1 therapy in murine tumor models. We reported that human Tregs express the ectonucleotidase CD39, which generates AMP from ATP, but do not express the AMPase CD73. In contrast, CD73 defined a subset of effect...

journal_title：Cancer research

authors： Gourdin N,Bossennec M,Rodriguez C,Vigano S,Machon C,Jandus C,Bauché D,Faget J,Durand I,Chopin N,Tredan O,Marie JC,Dubois B,Guitton J,Romero P,Caux C,Ménétrier-Caux C

更新日期：2018-07-01 00:00:00

abstract：:Beta-L-(-)-dioxolane cytidine [(-)-OddC] is the first nucleoside analogue with the unnatural L configuration shown to have anticancer activity. The transport and metabolism of this unique compound were studied in human prostate carcinoma DU-145 cells. (-)-OddC was translocated rapidly into the cells by both equilibrat...

journal_title：Cancer research

authors： Grove KL,Cheng YC

更新日期：1996-09-15 00:00:00

abstract：:The localization of biliary glycoprotein (BGP) and its mRNA in normal colonic mucosa was studied by immunohistochemistry and in situ hybridization. BGP mRNA was confined to columnar epithelial cells and expressed abundantly in the superficial mature cells and at low levels in differentiating cells in the upper crypts....

journal_title：Cancer research

authors： Frängsmyr L,Baranov V,Prall F,Yeung MM,Wagener C,Hammarström S

更新日期：1995-07-15 00:00:00

abstract：:To prevent their recognition as DNA breaks, the ends of linear chromosomes are organized into telomeres, which are made of proteins bound to telomere-specific, double-stranded repeats and to single-stranded DNA extensions, the G-tails. The mammalian heterogeneous nuclear ribonucleoparticule A1 and A2 proteins can bind...

journal_title：Cancer research

authors： Patry C,Bouchard L,Labrecque P,Gendron D,Lemieux B,Toutant J,Lapointe E,Wellinger R,Chabot B

更新日期：2003-11-15 00:00:00

abstract：:Our understanding of noncoding mutations in cancer genomes has been derived primarily from mutational recurrence analysis by aggregating clinical samples on a large scale. These cohort-based approaches cannot directly identify individual pathogenic noncoding mutations from personal cancer genomes. Therefore, although ...

journal_title：Cancer research

authors： Wang C,Li J

更新日期：2020-11-01 00:00:00

abstract：:In the immediately preceding paper, we demonstrated that the microvasculature supplying peritoneal lining tissues of mice bearing either of two transplantable ascites carcinomas was hyperpermeable to circulating macromolecules. Solid tumors have been shown to exhibit similar levels of microvascular hyperpermeability, ...

journal_title：Cancer research

authors： Nagy JA,Meyers MS,Masse EM,Herzberg KT,Dvorak HF

更新日期：1995-01-15 00:00:00

abstract：:Metronomic chemotherapy refers to the close, regular administration of comparatively low doses of cytotoxic drugs, with minimal or no drug-free breaks, over prolonged periods. It is thought to have an antiangiogenic basis. However, whereas surprisingly durable and potent tumor responses have been observed in a number ...

journal_title：Cancer research

authors： Shaked Y,Emmenegger U,Francia G,Chen L,Lee CR,Man S,Paraghamian A,Ben-David Y,Kerbel RS

更新日期：2005-08-15 00:00:00

abstract：:Targeting cancer cell metabolism is a new promising strategy to fight cancer. Metformin, a widely used antidiabetic agent, exerts antitumoral and antiproliferative action. In this study, the addition of metformin to 2-deoxyglucose (2DG) inhibited mitochondrial respiration and glycolysis in prostate cancer cells leadin...

journal_title：Cancer research

authors： Ben Sahra I,Laurent K,Giuliano S,Larbret F,Ponzio G,Gounon P,Le Marchand-Brustel Y,Giorgetti-Peraldi S,Cormont M,Bertolotto C,Deckert M,Auberger P,Tanti JF,Bost F

更新日期：2010-03-15 00:00:00

abstract：:In normal tissues, the steady-state level of CD44 mRNA is low, and the variety of alternatively spliced transcripts produced by this complex gene is limited. Conversely, increased and disorderly expression of this gene has been observed in a number of types of cancer. This study analyzed the order in which the CD44 va...

journal_title：Cancer research

authors： Goodison S,Yoshida K,Sugino T,Woodman A,Gorham H,Bolodeoku J,Kaufmann M,Tarin D

更新日期：1997-08-01 00:00:00

abstract：:Nkx2.8, a homeodomain transcription factor, has been characterized in liver cancer and in the developing central nervous system. We now show that this factor is also expressed in the lung, where it localizes in adults to a discrete population of tracheobronchial basal cells. To target the mouse gene, the first exon wa...

journal_title：Cancer research

authors： Tian J,Mahmood R,Hnasko R,Locker J

更新日期：2006-11-01 00:00:00

abstract：:Mice bearing the immunosuppressive plasmacytoma TEPC-183 exhibit a marked splenic hyperplasia. We have characterized these tumor-reactive splenocytes on the basis of cell surface marker expression, nonspecific esterase activity, and morphology. Although splenocyte numbers increased progressively throughout tumor growt...

journal_title：Cancer research

authors： Shanahan TC,Ceglowski WS,Havas HF

更新日期：1985-12-01 00:00:00

abstract：:Pluripotent cells within embryonal carcinoma (EC) can differentiate in vivo or in vitro on treatment with specific agents. Differentiating EC cells express lower levels of stem cell-related genes, such as Cripto-1. We show that migration of human EC cells (NTERA/2 and NCCIT) can be reduced following treatment with the...

journal_title：Cancer research

authors： Mancino M,Esposito C,Watanabe K,Nagaoka T,Gonzales M,Bianco C,Normanno N,Salomon DS,Strizzi L

更新日期：2009-03-01 00:00:00

abstract：:A monoclonal antibody prepared against the Rauscher virus envelope glycoprotein with a molecular weight of 70,000 targeted to neoplastic cells and cured the Rauscher leukemia virus-induced erythroleukemia in BALB/c mice. This antibody, 103A, specifically reacted with the Rauscher and Friend erythroleukemia viruses and...

journal_title：Cancer research

authors： Scheinberg DA,Strand M

更新日期：1982-01-01 00:00:00

abstract：:There is a paucity of data on whether or not women can be reinfected with human papillomavirus (HPV) types to which they were exposed to earlier in life and on the role of natural immunity. The observation of HPV infection at older ages may be explained by the reactivation of a latent infection or new exposure from se...

journal_title：Cancer research

authors： Trottier H,Ferreira S,Thomann P,Costa MC,Sobrinho JS,Prado JC,Rohan TE,Villa LL,Franco EL

更新日期：2010-11-01 00:00:00

abstract：:Elevation of the DNA-unwinding helicase RECQL4, which participates in various DNA repair pathways, has been suggested to contribute to the pathogenicity of various human cancers, including gastric cancer. In this study, we addressed the prognostic and chemotherapeutic significance of RECQL4 in human gastric cancer, wh...

journal_title：Cancer research

authors： Mo D,Fang H,Niu K,Liu J,Wu M,Li S,Zhu T,Aleskandarany MA,Arora A,Lobo DN,Madhusudan S,Balajee AS,Chi Z,Zhao Y

更新日期：2016-05-15 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a member of the nuclear receptor (NR) family of transcription factors with important regulatory roles in cellular growth, differentiation, and apoptosis. Using proteomic analysis, we showed expression of PPARgamma protein in a series of 260 newly diagnose...

journal_title：Cancer research

authors： Tsao T,Kornblau S,Safe S,Watt JC,Ruvolo V,Chen W,Qiu Y,Coombes KR,Ju Z,Abdelrahim M,Schober W,Ling X,Kardassis D,Meyer C,Schimmer A,Kantarjian H,Andreeff M,Konopleva M

更新日期：2010-06-15 00:00:00

abstract：:Mismatch repair (MMR) deficiency was reported to increase resistance of mammalian cells to killing by several genotoxic substances. However, although MMR-deficient cells are approximately 100-fold more resistant to killing by S(N)1 type methylating agents than MMR-proficient controls, the sensitivity differences repor...

journal_title：Cancer research

authors： Papouli E,Cejka P,Jiricny J

更新日期：2004-05-15 00:00:00