Cost of atopic dermatitis and eczema in the United States.

Abstract:

BACKGROUND:Atopic dermatitis/eczema (AD/E) is a common disease. Few studies have attempted to quantify the cost to third-party payers. OBJECTIVE:Our purpose was to identify the annual cost of medical services and prescription drugs for the treatment of AD/E to private insurance and Medicaid payers in the United States. METHODS:We used a retrospective study design employing claims data from 1997 and 1998 from a private insurer and a state Medicaid program to analyze costs incurred. Beneficiaries were considered to have AD/E if they had at least one claim in 1997 with a primary or secondary listing of 1 of 3 diagnosis codes: 691.8, other atopic dermatitis and related conditions; 692.9, contact dermatitis and other eczema when no cause is specified; or 373.3, noninfectious dermatoses of eyelid. Patients who did not meet the diagnosis criteria served as a control group in each payer for comparisons of expenditures with the AD/E group. RESULTS:Disease prevalence was 2.4% (private insurer) to 2.6% (Medicaid) of all eligible beneficiaries, and 3.5% to 4.1% of patients submitted at least one health care claim during the study period. Medicaid-insured patients used outpatient hospital visits and hospitalizations at a greater rate than did privately insured patients; neither used emergency departments extensively. The third-party payer cost of illness for AD/E ranged from $0.9 billion to $3.8 billion when projected across the total number of persons younger than 65 years insured by private insurers and Medicaid in the United States. More than one fourth of all health care costs for patients with AD/E may be attributed to AD/E and co-morbid conditions. CONCLUSIONS:Annual costs of AD/E are similar to those of other diseases such as emphysema, psoriasis, and epilepsy. Patients incur significant costs associated with AD/E and co-morbid conditions.

journal_name

J Am Acad Dermatol

authors

Ellis CN,Drake LA,Prendergast MM,Abramovits W,Boguniewicz M,Daniel CR,Lebwohl M,Stevens SR,Whitaker-Worth DL,Cheng JW,Tong KB

doi

10.1067/mjd.2002.120528

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

361-70

issue

3

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(02)97717-0

journal_volume

46

pub_type

杂志文章
  • Treatment of anogenital warts with imiquimod 5% cream followed by surgical excision of residual lesions.

    abstract::Cytodestructive or surgical therapy for patients with anogenital warts is frequently associated with recurrence. In February 1997, the US Food and Drug Administration approved imiquimod as a 5% cream for the treatment of anogenital warts. Activity of the drug results primarily from interferon alfa and other cytokine i...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1067/mjd.2002.126579

    authors: Carrasco D,vander Straten M,Tyring SK

    更新日期:2002-10-01 00:00:00

  • Epidermal nevus syndrome: association with central precocious puberty and woolly hair nevus.

    abstract::The epidermal nevus syndrome is characterized by the association of epidermal nevi with abnormalities of the skin, skeletal system, central nervous system, eyes, and cardiovascular system, as well as with malignant conditions. We describe a 2-year-old girl with an extensive epidermal nevus involving the left side of t...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(96)90098-5

    authors: Tay YK,Weston WL,Ganong CA,Klingensmith GJ

    更新日期:1996-11-01 00:00:00

  • Comparative Safety of Systemic Immuno-modulatory Medications in Adults with Atopic Dermatitis.

    abstract:BACKGROUND:Severe atopic dermatitis (AD) is increasingly treated with systemic immuno-modulatory drugs yet their safety is unclear. OBJECTIVE:We evaluated the comparative risk of serious bacterial and opportunistic infections among users of systemic immuno-modulatory medications in patients with severe AD in routine c...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2019.05.073

    authors: Schneeweiss MC,Perez-Chada L,Merola JF

    更新日期:2019-05-31 00:00:00

  • A nongrading histologic approach to Clark (dysplastic) nevi: A potential to decrease the excision rate.

    abstract:BACKGROUND:Despite a lack of evidence that dysplastic nevi are precursors to melanoma, a large proportion of dermatologists continue to treat them as such. Emerging data suggest that histologic grading approach may result in many unnecessary excisions. OBJECTIVE:Using a nongrading approach to diagnosis of Clark/dyspla...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2015.09.030

    authors: Lozeau DF,Farber MJ,Lee JB

    更新日期:2016-01-01 00:00:00

  • Accuracy of dermoscopic criteria for the differential diagnosis between irritated seborrheic keratosis and squamous cell carcinoma.

    abstract:BACKGROUND:Even with the addition of dermoscopy, a significant morphologic overlap exists between irritated seborrheic keratosis (ISK) and squamous cell carcinoma (SCC). OBJECTIVE:The aim of this study was to investigate the dermoscopic criteria that could serve as potent predictors for the differential diagnosis betw...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2020.02.019

    authors: Papageorgiou C,Spyridis I,Manoli SM,Busila I,Nasturica IE,Lallas K,Panagopoulou A,Papadimitriou I,Sideris N,Gentsidi T,Gonzalez-Cuevas R,Ilieva A,Ioannides D,Apalla Z,Lallas A

    更新日期:2020-02-14 00:00:00

  • Remission of refractory pyoderma gangrenosum, severe acne, and hidradenitis suppurativa (PASH) syndrome using targeted antibiotic therapy in 4 patients.

    abstract::Pyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance thera...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2015.07.040

    authors: Join-Lambert O,Duchatelet S,Delage M,Miskinyte S,Coignard H,Lemarchand N,Alemy-Carreau M,Lortholary O,Nassif X,Hovnanian A,Nassif A

    更新日期:2015-11-01 00:00:00

  • Epstein-Barr virus-associated large granular lymphocyte leukemia with cutaneous infiltration.

    abstract::A 36-year-old man had a high titer of antibody to Epstein-Barr virus (EBV) and recurrent necrotizing papules and nodules on his face and oral mucosa. The disease was diagnosed as CD3+4- 8+ large granular lymphocyte leukemia of T-cell origin. Southern blot analysis demonstrated that EBV DNA was present in CD8+ lymphocy...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(94)70157-1

    authors: Asada H,Okada N,Tei H,Yamamura T,Hashimoto K,Kondo K,Yamanishi K,Yoshikawa K

    更新日期:1994-08-01 00:00:00

  • A systematic review of patient-reported outcome instruments of nonmelanoma skin cancer in the dermatologic population.

    abstract:BACKGROUND:Treatment of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) has traditionally focused on minimizing recurrence and complication rates. However, the assessment of patient satisfaction and quality of life (QOL) is also important. These outcomes are best assessed by patient-reported outcome (PRO) ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2012.09.017

    authors: Lee EH,Klassen AF,Nehal KS,Cano SJ,Waters J,Pusic AL

    更新日期:2013-08-01 00:00:00

  • Histiocytoid Sweet syndrome may indicate leukemia cutis: a novel application of fluorescence in situ hybridization.

    abstract:BACKGROUND:In patients with malignancy-associated Sweet syndrome, a thorough evaluation for leukemia cutis should be considered. OBJECTIVE:We sought to describe the clinicopathologic characteristics of histiocytoid Sweet syndrome. METHODS:We retrospectively identified patients with histiocytoid Sweet syndrome at our ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2014.01.874

    authors: Chavan RN,Cappel MA,Ketterling RP,Wada DA,Rochet NM,Knudson R,Gibson LE

    更新日期:2014-06-01 00:00:00

  • Characterization of clinical photosensitivity in cutaneous lupus erythematosus.

    abstract:BACKGROUND:Photosensitivity (PS) in lupus erythematosus (LE) is frequently determined by patient report. OBJECTIVE:We sought to characterize self-reported PS in cutaneous LE (CLE). METHODS:The PS survey was used to classify subject responses into 5 phenotypes: direct sun-induced CLE flare (directCLE); general exacerb...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2013.03.015

    authors: Foering K,Chang AY,Piette EW,Cucchiara A,Okawa J,Werth VP

    更新日期:2013-08-01 00:00:00

  • Bath-5-methoxypsoralen-UVA therapy for psoriasis.

    abstract:BACKGROUND:After oral intake, 5-methoxypsoralen (5-MOP) is as effective as 8-MOP for PUVA therapy for psoriasis, with a lower incidence of acute cutaneous side effects. OBJECTIVE:We compared bath-water delivery of 5-MOP and 8-MOP for photochemotherapy of psoriasis. METHODS:Twenty-two patients underwent phototesting w...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(97)80278-2

    authors: Calzavara-Pinton PG,Zane C,Carlino A,De Panfilis G

    更新日期:1997-06-01 00:00:00

  • UV hardening therapy: a novel intervention in patients with photosensitive cutaneous lupus erythematosus.

    abstract:BACKGROUND:Patients with cutaneous lupus erythematosus (LE) and a history of disease- related photoaggravation, confirmed by phototesting, may not respond to photoprotection and/or medical intervention. Ultraviolet B-hardening therapy may improve tolerance for environmental ultraviolet radiation (UVR) in photosensitive...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2005.10.046

    authors: Sanders CJ,Lam HY,Bruijnzeel-Koomen CA,Sigurdsson V,van Weelden H

    更新日期:2006-03-01 00:00:00

  • Cutaneous side effects of epidermal growth factor receptor inhibitors: clinical presentation, pathogenesis, and management.

    abstract::The growing investigation and use of epidermal growth factor receptor (EGFR) inhibitors in anticancer therapy has been motivated by their specificity for EGFR, which improves their ability to target cancer cells and enhances their safety profile compared with many other conventional chemotherapeutic agents. However, t...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2006.09.005

    authors: Hu JC,Sadeghi P,Pinter-Brown LC,Yashar S,Chiu MW

    更新日期:2007-02-01 00:00:00

  • Alopecia and periorificial dermatitis in biotin-responsive multiple carboxylase deficiency.

    abstract::Three siblings with infantile-onset biotin-responsive multiple carboxylase deficiency are described. Recognition of the characteristic dermatologic manifestations, alopecia and periorificial dermatitis, should result in early diagnosis and institution of potentially lifesaving therapy with biotin. Other metabolic diso...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(83)70113-1

    authors: Williams ML,Packman S,Cowan MJ

    更新日期:1983-07-01 00:00:00

  • Patient burden of moderate to severe atopic dermatitis (AD): Insights from a phase 2b clinical trial of dupilumab in adults.

    abstract:BACKGROUND:The adult burden of atopic dermatitis (AD) is poorly characterized. OBJECTIVE:We sought to characterize AD burden in adults with moderate to severe disease from the patient's perspective. METHODS:Patient-reported outcomes collected at screening in a phase 2b clinical trial of dupilumab included pruritus nu...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaad.2015.10.043

    authors: Simpson EL,Bieber T,Eckert L,Wu R,Ardeleanu M,Graham NM,Pirozzi G,Mastey V

    更新日期:2016-03-01 00:00:00

  • Mental health impairment among children with atopic dermatitis: A United States population-based cross-sectional study of the 2013-2017 National Health Interview Survey.

    abstract:BACKGROUND:Atopic dermatitis (AD) is associated with mental health disorders, but its impact on global mental health symptoms is less clear. OBJECTIVE:To determine the association between pediatric AD and mental health impairment. METHODS:In a cross-sectional study using 2013-2017 United States National Health Interv...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2019.10.019

    authors: Wan J,Takeshita J,Shin DB,Gelfand JM

    更新日期:2020-06-01 00:00:00

  • Linear extragenital lichen sclerosus with underlying bony atrophy.

    abstract::We describe a 21-year-old male patient with linear extragenital lichen sclerosus. The lesions are confined to the left side of his body and consist of 3 long bands running along the left leg and several patchy and linear lesions on the left side of his trunk. An associated finding is a smaller diameter of the distal p...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2003.09.015

    authors: Pavlović MD

    更新日期:2004-03-01 00:00:00

  • A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women.

    abstract:BACKGROUND:Although twice-daily application of propylene glycol-containing 2% minoxidil topical solution (MTS) stimulates new hair growth, higher concentrations of minoxidil in a once-daily, propylene glycol-free formulation may improve efficacy and reduce unpleasant side effects. OBJECTIVE:We sought to compare the ef...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaad.2010.09.724

    authors: Blume-Peytavi U,Hillmann K,Dietz E,Canfield D,Garcia Bartels N

    更新日期:2011-12-01 00:00:00

  • Methyldibromoglutaronitrile (Euxyl K400): a new and important sensitizer in the United States?

    abstract:BACKGROUND:Methyldibromoglutaronitrile (MDGN) is a component of Euxyl K400, a preservative used in many skin care products in Europe. MDGN has been used in skin care products in the United States for the last 5 years. Contact allergy from MDGN has been reported from Europe. OBJECTIVE:The purpose of this study was to d...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(98)70589-4

    authors: Jackson JM,Fowler JF

    更新日期:1998-06-01 00:00:00

  • Porokeratosis of Mibelli: benzylhydrochlorothiazide-induced new lesions accompanied by eosinophilic spongiosis.

    abstract::We observed the course of development of porokeratosis stimulated by benzylhydrochlorothiazide (BHCTh) in normal-appearing skin of a patient with long-standing stable porokeratosis of Mibelli. A 72-year-old Japanese man had had porokeratosis of Mibelli for more than 50 years. During administration of BHCTh for 1 year ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(84)70172-1

    authors: Inamoto N,Watanabe T,Nakamura K

    更新日期:1984-08-01 00:00:00

  • The inadequacy of punch-excised melanocytic lesions: sampling through the block for the determination of "margins".

    abstract:BACKGROUND:Dermatopathologists often are asked by clinicians to report margins on punch excisions of melanocytic lesions. OBJECTIVE:We sought to determine the adequacy of surgical margins on melanocytic lesions submitted with intention of complete excision using punch removal technique. METHODS:We conducted prospecti...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2008.09.037

    authors: Chang TT,Somach SC,Wagamon K,Somani AK,Pomeranz J,Jaworsky C,Bass J,Winfield HL,Sigel JE,Rosenberg AS

    更新日期:2009-06-01 00:00:00

  • Superantigens in dermatology.

    abstract::Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against S...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2010.03.044

    authors: Macias ES,Pereira FA,Rietkerk W,Safai B

    更新日期:2011-03-01 00:00:00

  • Primary idiopathic cutaneous pustular vasculitis.

    abstract::Pustular cutaneous vasculitis results from a heterogeneous group of disorders characterized by pustules on purpuric bases. Although the cause of this group of conditions is diverse, the histopathologic picture of the lesions is the same, showing a Sweet's-like or leukocytoclastic vasculitis. These distinctive lesions ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(86)70116-3

    authors: McNeely MC,Jorizzo JL,Solomon AR Jr,Schmalstieg FC,Cavallo T

    更新日期:1986-05-01 00:00:00

  • A nomogram to identify high-risk melanoma patients with a negative sentinel lymph node biopsy.

    abstract:BACKGROUND:Melanoma patients with negative nodes after sentinel lymph node biopsy are a heterogeneous group. Current guidelines fail to adequately stratify surveillance and treatment for this group. Also, there is scarce data on adjuvant treatments for these patients. OBJECTIVE:To create a nomogram including clinical ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2018.10.060

    authors: Bertolli E,de Macedo MP,Calsavara VF,Pinto CAL,Duprat Neto JP

    更新日期:2019-03-01 00:00:00

  • Comparison of detection of varicella-zoster virus by the Tzanck smear, direct immunofluorescence with a monoclonal antibody, and virus isolation.

    abstract::A study comparing direct immunofluorescence assay using a new monoclonal antibody specific for a varicella-zoster virus glycoprotein complex, the Tzanck smear, and virus isolation for detection of varicella-zoster virus in 56 patients with clinically apparent herpes zoster is presented. Of 47 patients with clinical he...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(87)70172-8

    authors: Sadick NS,Swenson PD,Kaufman RL,Kaplan MH

    更新日期:1987-07-01 00:00:00

  • A clinical trial comparing the safety and efficacy of a topical erythromycin-zinc formulation with a topical clindamycin formulation.

    abstract::One hundred three patients with acne vulgaris were randomly designated to receive either a topical formulation of erythromycin plus zinc or a topical solution of 1% clindamycin phosphate (Cleocin-T). The patients treated themselves twice daily and were examined at 3, 6, 9, and 12 weeks after the start of therapy. By w...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0190-9622(90)70069-t

    authors: Schachner L,Pestana A,Kittles C

    更新日期:1990-03-01 00:00:00

  • Tumid lupus erythematosus occurring following highly active antiretroviral therapy for HIV infection: a manifestation of immune restoration.

    abstract::Tumid lupus erythematosus (LE) is a relatively rare and only recently recognized subset of chronic cutaneous lupus. We report a case occurring in a male with HIV infection whereby his rash was only unmasked by immune restoration following highly active antiretroviral therapy (HAART). The phenomenon of latent inflammat...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2004.04.020

    authors: Chamberlain AJ,Hollowood K,Turner RJ,Byren I

    更新日期:2004-11-01 00:00:00

  • Indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells and macrophages in infectious and noninfectious cutaneous granulomas.

    abstract:BACKGROUND:The enzyme indoleamine 2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan, and this degradation is an immunosuppressive mechanism that is mainly used by antigen-presenting cells. IDO-expressing dendritic cells and macrophages have previously been identified as components of lymph node granulo...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2010.07.050

    authors: von Bubnoff D,Scheler M,Wilms H,Wenzel J,von Bubnoff N,Häcker G,Schultze J,Popov A,Racz P,Bieber T,Wickenhauser C

    更新日期:2011-10-01 00:00:00

  • A randomized pilot comparative study of topical methyl aminolevulinate photodynamic therapy versus imiquimod 5% versus sequential application of both therapies in immunocompetent patients with actinic keratosis: clinical and histologic outcomes.

    abstract:BACKGROUND:Photodynamic therapy (PDT) and imiquimod are the treatments of choice for actinic keratosis (AK). As they have different mechanisms of action, it seems reasonable to assume that applying both treatments sequentially would be efficacious. OBJECTIVES:We sought to determine which of these therapeutic modalitie...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaad.2011.11.933

    authors: Serra-Guillén C,Nagore E,Hueso L,Traves V,Messeguer F,Sanmartín O,Llombart B,Requena C,Botella-Estrada R,Guillén C

    更新日期:2012-04-01 00:00:00

  • Immunohistochemical staining of lentigo maligna during Mohs micrographic surgery using MART-1.

    abstract:BACKGROUND:Lentigo maligna (LM) often displays extensive subclinical spread. Mohs micrographic surgery (MMS) has been proposed to help delineate the true histologic margin; however, visualizing atypical melanocytes on frozen section is challenging and often requires confirmatory permanent paraffin sections. OBJECTIVE:...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2002.119197

    authors: Kelley LC,Starkus L

    更新日期:2002-01-01 00:00:00