Estimating HIV-1 transmission efficiency through unsafe medical injections.

Abstract:

:The transmission efficiency of HIV-1 through unsafe medical injections can be estimated from seroconversions among health care workers (HCWs) after percutaneous exposures and documented iatrogenic outbreaks. Data from a case-control study of seroconversion after percutaneous exposures among US and European HCWs shows an average rate of seroconversion after deep injuries - arguably comparable to unsafe injections - of 2.3%. Information from an iatrogenic HIV outbreak in a Romanian orphanage suggests a transmission efficiency of 2-7%. Even these estimates may be too low to explain the rapid spread of HIV among Russian and Libyan children in iatrogenic outbreaks discovered in 1988 and 1998, respectively. In countries in sub-Saharan Africa and elsewhere with high HIV prevalence and large numbers of unsafe injections, personal risk as well as the share of the HIV epidemic associated with unsafe injections may be an order of magnitude higher that many experts have supposed.

journal_name

Int J STD AIDS

authors

Gisselquist DP

doi

10.1258/0956462021924820

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

152-9

issue

3

eissn

0956-4624

issn

1758-1052

journal_volume

13

pub_type

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