Abstract:
:The retrognathic Brachyrrhine (Br) heterozygote mouse mutant has a very localized morphological deficiency in the sphenoethmoidal region of the anterior cranial base. The purpose of this study was to test the hypothesis that a primary growth defect occurs in that region of Br mice. Primary cell cultures were derived from presumptive nasal septal and sphenoethmoidal regions of Br and wild-type littermates. Cultures were stimulated with 1.0 ng/ml epidermal growth factor (EGF), and [3H]thymidine and [35S] incorporation was measured. Growth of the nasal septal chondrocytes did not differ significantly between groups. In the cultures derived from the sphenoethmoidal region [35S] incorporation was greater, but not significantly so, in the normal group. However, EGF did significantly stimulate proliferation of the sphenoethmoidal chondrocytes in wild-type cultures above that measured in Br cultures. Therefore, the Br genetic aberration is associated with a primary growth defect in the sphenoethmoidal region of the cranial base. These results suggest that growth of the anterior cranial base occurs differentially and that the defect in Br mice results in reduced sphenoidal but not nasal septal growth.
journal_name
Arch Oral Bioljournal_title
Archives of oral biologyauthors
Ma W,Lozanoff Sdoi
10.1016/s0003-9969(01)00105-4subject
Has Abstractpub_date
2002-02-01 00:00:00pages
155-63issue
2eissn
0003-9969issn
1879-1506pii
S0003996901001054journal_volume
47pub_type
杂志文章abstract:OBJECTIVES:To assess the association between the promoter region of serotonin transporter (5-HTTLPR) gene polymorphism and recurrent aphthous stomatitis (RAS) occurrence. DESIGNS:We performed the meta-analysis to determine the potential association between 5-HTTLPR polymorphism and RAS. We retrieved revelant studies f...
journal_title:Archives of oral biology
pub_type: 杂志文章,meta分析
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更新日期:2020-01-01 00:00:00
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journal_title:Archives of oral biology
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pub_type: 杂志文章
doi:10.1016/0003-9969(95)00010-m
更新日期:1995-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:Archives of oral biology
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2010.03.012
更新日期:2010-05-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2011.10.021
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journal_title:Archives of oral biology
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Archives of oral biology
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更新日期:2017-11-01 00:00:00
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章,评审
doi:10.1016/j.archoralbio.2014.11.011
更新日期:2015-02-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(82)90185-6
更新日期:1982-01-01 00:00:00
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更新日期:2007-04-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
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更新日期:2000-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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更新日期:2021-01-08 00:00:00
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更新日期:2016-01-01 00:00:00
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更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/s0003-9969(98)00019-3
更新日期:1998-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-11-01 00:00:00