The involvement of the mu-opioid receptor in ketamine-induced respiratory depression and antinociception.

Abstract:

UNLABELLED:N-methyl-D-aspartate receptor antagonism probably accounts for most of ketamine's anesthetic effects; its analgesic properties are mediated partly via N-methyl-D-aspartate and partly via opioid receptors. We assessed the involvement of the mu-opioid receptor in S(+) ketamine-induced respiratory depression and antinociception by performing dose-response curves in exon 2 mu-opioid receptor knockout mice (MOR(-/-)) and their wild-type littermates (WT). The ventilatory response to increases in inspired CO(2) was measured with whole body plethysmography. Two antinociceptive assays were used: the tail-immersion test and the hotplate test. S(+) ketamine (0, 10, 100, and 200 mg/kg intraperitoneally) caused a dose-dependent respiratory depression in both genotypes, with greater depression observed in WT relative to MOR(-/-) mice. At 200 mg/kg, S(+) ketamine reduced the slope of the hypercapnic ventilatory response by 93% +/- 15% and 49% +/- 6% in WT and MOR(-/-) mice, respectively (P < 0.001). In both genotypes, S(+) ketamine produced a dose-dependent increase in latencies in the hotplate test, with latencies in MOR(-/-) mice smaller compared with those in WT animals (P < 0.05). In contrast to WT mice, MOR(-/-) mice displayed no ketamine-induced antinociception in the tail-immersion test. These results indicate that at supraspinal sites S(+) ketamine interacts with the mu-opioid system. This interaction contributes significantly to S(+) ketamine-induced respiratory depression and supraspinal antinociception. IMPLICATIONS:The involvement of the mu-opioid receptor system in S(+) ketamine-induced respiratory depression and spinal and supraspinal analgesia was demonstrated by performing experiments in mice lacking the mu-opioid receptor and in mice with intact mu-opioid receptors.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Sarton E,Teppema LJ,Olievier C,Nieuwenhuijs D,Matthes HW,Kieffer BL,Dahan A

doi

10.1097/00000539-200112000-00031

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

1495-500, table of contents

issue

6

eissn

0003-2999

issn

1526-7598

journal_volume

93

pub_type

杂志文章
  • The Society for Obstetric Anesthesia and Perinatology consensus statement on the management of cardiac arrest in pregnancy.

    abstract::This consensus statement was commissioned in 2012 by the Board of Directors of the Society for Obstetric Anesthesia and Perinatology to improve maternal resuscitation by providing health care providers critical information (including point-of-care checklists) and operational strategies relevant to maternal cardiac arr...

    journal_title:Anesthesia and analgesia

    pub_type: 指南,杂志文章,评审

    doi:10.1213/ANE.0000000000000171

    authors: Lipman S,Cohen S,Einav S,Jeejeebhoy F,Mhyre JM,Morrison LJ,Katz V,Tsen LC,Daniels K,Halamek LP,Suresh MS,Arafeh J,Gauthier D,Carvalho JC,Druzin M,Carvalho B,Society for Obstetric Anesthesia and Perinatology.

    更新日期:2014-05-01 00:00:00

  • Does preoperative anxiety influence gastric fluid volume and acidity?

    abstract::Preoperative anxiety may increase gastric fluid acidity and volume. To pursue this possibility we evaluated the relationship between peroral premedication, preoperative anxiety, and gastric content in 246 consecutive patients presenting for elective gynecologic surgery. All patients fasted overnight and received eithe...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199207000-00017

    authors: Haavik PE,Søreide E,Hofstad B,Steen PA

    更新日期:1992-07-01 00:00:00

  • A comparison of peripheral skin blood flow and temperature during endoscopic thoracic sympathotomy.

    abstract::The assessment of sympathetic denervation to the upper extremities during surgery for hyperhidrosis is essential in predicting postoperative outcome, particularly for endoscopic thoracic chain sympathotomy, a recently described, minimally destructive technique that minimizes postoperative compensatory hyperhidrosis. T...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ANE.0000139934.15659.7F

    authors: Eisenach JH,Pike TL,Wick DE,Dietz NM,Fealey RD,Atkinson JL,Charkoudian N

    更新日期:2005-01-01 00:00:00

  • Educating Patients Regarding Pain Management and Safe Opioid Use After Surgery: A Narrative Review.

    abstract::In recent years, there have been escalating concerns related to the opioid epidemic. With a steadily increasing opioid supply, it is critical to provide proper education to patients who are prescribed these medications. Education should be emphasized as a means of ensuring safe use and potentially as a strategy for cu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000004436

    authors: Lee BH,Wu CL

    更新日期:2020-03-01 00:00:00

  • A tribute to Dr. Paul A. J. Janssen: entrepreneur extraordinaire, innovative scientist, and significant contributor to anesthesiology.

    abstract::Dr. Paul Janssen was the founder of Janssen Pharmaceutica and the developer of over 80 pharmaceutical compounds that proved useful in human, botanical, and veterinary medicine. He and his coworkers synthesized the fentanyl family of drugs, many other potent analgesics, droperidol, etomidate, and numerous other importa...

    journal_title:Anesthesia and analgesia

    pub_type: 传,历史文章,杂志文章

    doi:10.1213/ane.0b013e3181605add

    authors: Stanley TH,Egan TD,Van Aken H

    更新日期:2008-02-01 00:00:00

  • The effect of breath termination criterion on breathing patterns and the work of breathing during pressure support ventilation.

    abstract:UNLABELLED:With pressure support ventilation (PSV), each PSV breath is flow-cycled, and the breath termination criterion (TC) is usually nonadjustable. When TC does not match the interaction between the patient's inspiratory-expiratory efforts to the opening and closing of the inspiratory and expiratory valves, patient...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200101000-00031

    authors: Tokioka H,Tanaka T,Ishizu T,Fukushima T,Iwaki T,Nakamura Y,Kosogabe Y

    更新日期:2001-01-01 00:00:00

  • Dexmedetomidine sedation leading to refractory cardiogenic shock.

    abstract::Dexmedetomidine is frequently used for deep sedation during electrophysiology procedures. We report a case where, presumably, the use of dexmedetomidine resulted in a patient's death. The patient developed unexplained and refractory cardiogenic shock and could not be resuscitated. Autopsy failed to demonstrate any abn...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e318172fafc

    authors: Sichrovsky TC,Mittal S,Steinberg JS

    更新日期:2008-06-01 00:00:00

  • Patient preferences for early discharge after laparoscopic cholecystectomy.

    abstract:UNLABELLED:Patients may have concerns about their ability to manage postoperative symptoms at home after ambulatory surgery. We assessed patients' attitudes toward postoperative care at home or in the hospital after laparoscopic cholecystectomy. Thirty-eight patients undergoing elective laparoscopic cholecystectomy wer...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199906000-00015

    authors: Lehmann HP,Fleisher LA,Lam J,Frink BA,Bass EB

    更新日期:1999-06-01 00:00:00

  • Peripheral flow index is a reliable and early indicator of regional block success.

    abstract::We investigated the usefulness of peripheral flow index (PFI) measurement using a standard pulse oximetry digit probe for early prediction of successful regional blocks. Sixty-six patients scheduled for limb surgery underwent either axillary or sciatic block using a nerve stimulator technique with mepivacaine 1.5%. PF...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000220947.02689.9f

    authors: Galvin EM,Niehof S,Verbrugge SJ,Maissan I,Jahn A,Klein J,van Bommel J

    更新日期:2006-07-01 00:00:00

  • Impact of an Analgesia-Based Sedation Protocol on Mechanically Ventilated Patients in a Medical Intensive Care Unit.

    abstract:BACKGROUND:Recent attention to adverse effects of intensive care unit (ICU) sedation has led to the use of strategies that target a "lighter" depth of sedation. Among these strategies are "analgosedation" protocols, which prioritize pain management and preferentially use IV opioids before administration of continuously...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001393

    authors: Faust AC,Rajan P,Sheperd LA,Alvarez CA,McCorstin P,Doebele RL

    更新日期:2016-10-01 00:00:00

  • Paradoxical embolus after multiple trauma resulting in a cerebrovascular accident.

    abstract:UNLABELLED:We present the case of a 57-yr-old patient who suffered an unexplained cerebrovascular event 3 days after being struck by a motor vehicle. Workup demonstrated a previously unknown patient foramen ovale. The etiologies of paradoxical embolism in trauma are discussed. IMPLICATIONS:Paradoxical embolism after m...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000102069.59203.a4

    authors: Price MD,Kanake P,Talmor D

    更新日期:2004-04-01 00:00:00

  • Modeling the effect of propofol and remifentanil combinations for sedation-analgesia in endoscopic procedures using an Adaptive Neuro Fuzzy Inference System (ANFIS).

    abstract:BACKGROUND:The increasing demand for anesthetic procedures in the gastrointestinal endoscopy area has not been followed by a similar increase in the methods to provide and control sedation and analgesia for these patients. In this study, we evaluated different combinations of propofol and remifentanil, administered thr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e3182025a70

    authors: Gambús PL,Jensen EW,Jospin M,Borrat X,Martínez Pallí G,Fernández-Candil J,Valencia JF,Barba X,Caminal P,Trocóniz IF

    更新日期:2011-02-01 00:00:00

  • Ultrasound-guided peripheral nerve stimulator placement in two soldiers with acute battlefield neuropathic pain.

    abstract::Acute peripheral neuropathic pain after combat-related polytrauma is a common occurrence in the United States military that is often refractory to current drugs and regional anesthesia. Both spinal cord and peripheral nerve stimulation are successfully used for chronic neuropathic pain states, but are not reported for...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e318247f6b2

    authors: Kent M,Upp J,Spevak C,Shannon C,Buckenmaier C 3rd

    更新日期:2012-04-01 00:00:00

  • The inhibition of epidural morphine-induced pruritus by epidural droperidol.

    abstract:UNLABELLED:IV droperidol inhibits epidural morphine-induced pruritus, but this effect disappears when the dose is increased from 2.5 to 5.0 mg. This study was performed to determine whether epidural droperidol would have a similar effect. In this double-blinded study, we enrolled 140 patients undergoing Cesarean delive...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200003000-00025

    authors: Horta ML,Ramos L,Gonçalves ZR

    更新日期:2000-03-01 00:00:00

  • Significance of electrocardiographic ST elevation during coronary artery bypass surgery.

    abstract::The aim of this study was to determine the significance of new electrocardiographic (ECG) ST elevation during coronary artery bypass surgery. Multilead ECGs were recorded intraoperatively approximately every 3 min on 105 patients. Cases of new ST elevation were divided into ischemic and those considered to be due to n...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199404000-00004

    authors: Jain U,Wallis DE,Moran JF

    更新日期:1994-04-01 00:00:00

  • Vasopressin in hemorrhagic shock.

    abstract::We describe the treatment of two patients with hemorrhagic shock unresponsive to volume replacement and catecholamines. Both patients responded to a small-dose infusion of vasopressin, which allowed tapering off of the catecholamines. The possible role of small-dose infusions of vasopressin in fluid- and catecholamine...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000175209.61051.7F

    authors: Sharma RM,Setlur R

    更新日期:2005-09-01 00:00:00

  • N-acetylcysteine for the prevention of kidney injury in abdominal aortic surgery: a randomized, double-blind, placebo-controlled trial.

    abstract::In this prospective, randomized, placebo-controlled, double-blind trial we studied the effects of IV N-acetylcysteine for prevention of renal injury in patients undergoing abdominal aortic surgery. Seventy patients without previously documented renal dysfunction were randomly allocated to receive either N-acetylcystei...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000219590.79796.66

    authors: Hynninen MS,Niemi TT,Pöyhiä R,Raininko EI,Salmenperä MT,Lepäntalo MJ,Railo MJ,Tallgren MK

    更新日期:2006-06-01 00:00:00

  • The quality of randomized controlled trials in major anesthesiology journals.

    abstract::Increased attention has been directed at the quality of randomized controlled trials (RCTs) and how they are being reported. We examined leading anesthesiology journals to identify if there were specific areas for improvement in the design and analysis of published clinical studies. All RCTs that appeared between Janu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000150612.71007.A3

    authors: Greenfield ML,Rosenberg AL,O'Reilly M,Shanks AM,Sliwinski MJ,Nauss MD

    更新日期:2005-06-01 00:00:00

  • A comparison of target- and manually controlled infusion propofol and etomidate/desflurane anesthesia in elderly patients undergoing hip fracture surgery.

    abstract::Elderly patients have a higher risk of developing adverse drug reactions during anesthesia, especially anesthesia affecting cardiovascular performance. In this prospective randomized study we compared quality of induction, hemodynamics, and recovery in elderly patients scheduled for hip fracture surgery and receiving ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000149542.04833.55

    authors: Passot S,Servin F,Pascal J,Charret F,Auboyer C,Molliex S

    更新日期:2005-05-01 00:00:00

  • Capacity to give surgical consent does not imply capacity to give anesthesia consent: implications for anesthesiologists.

    abstract::There is precedent in medicine for recognizing and accepting intact decisional capacity and the subsequent ability to provide valid consent in one treatment domain, while simultaneously recognizing that the patient lacks decisional capacity in other domains. As such, obtaining consent for anesthesia for a surgical pro...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181c7eb12

    authors: Marcucci C,Seagull FJ,Loreck D,Bourke DL,Sandson NB

    更新日期:2010-02-01 00:00:00

  • Cardiac electrophysiologic effects of pancuronium.

    abstract::A microelectrode examination of guinea pig left ventricular papillary muscle was performed to determine whether there was a direct effect of pancuronium on cardiac cells and, if so, to attempt to ascertain the mechanism of this effect. Electrical events were measured before and during superfusion with pancuronium, epi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Jacobs HK,Lim S,Salem MR,Rao TL,Mathru M,Smith BD

    更新日期:1985-07-01 00:00:00

  • Safety and Efficacy of the Combination of Propofol and Ketamine for Procedural Sedation/Anesthesia in the Pediatric Population: A Systematic Review and Meta-analysis.

    abstract:BACKGROUND:Drugs such as propofol and ketamine are used alone or in combination to provide sedation for medical procedures in children. The purpose of this systematic review was to compare the safety and effectiveness of propofol and ketamine to other drug regimens. METHODS:We searched Medline, Embase, Cochrane Centra...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000004967

    authors: Hayes JA,Aljuhani T,De Oliveira K,Johnston BC

    更新日期:2020-07-07 00:00:00

  • Fentanyl, clonidine, and repeated increases in desflurane concentration, but not nitrous oxide or esmolol, block the transient mydriasis caused by rapid increases in desflurane concentration.

    abstract::Initial, but not subsequent, inhalation of 8% desflurane produces transient sympathetic stimulation. We hypothesized that initial but not subsequent increases should produce pupil dilation, and that N2O, fentanyl, and clonidine, but not esmolol, should blunt the response. In 10 volunteers, we maintained anesthesia wit...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199508000-00028

    authors: Daniel M,Larson MD,Eger EI 2nd,Noorani M,Weiskopf RB

    更新日期:1995-08-01 00:00:00

  • Development, Reporting, and Evaluation of Clinical Practice Guidelines.

    abstract::Clinical practice parameters have been published with greater frequency by professional societies and groups of experts. These publications run the gamut of practice standards, practice guidelines, consensus statements or practice advisories, position statements, and practice alerts. The definitions of these terms hav...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000004441

    authors: Benzon HT,Joshi GP,Gan TJ,Vetter TR

    更新日期:2019-12-01 00:00:00

  • Combination of ondansetron and droperidol in the prophylaxis of postoperative nausea and vomiting.

    abstract::The aim of this study was to compare the efficacy and safety of ondansetron plus droperidol with each drug alone or placebo in the prevention of postoperative nausea and vomiting (PONV). One hundred females, aged 18-65 yr, ASA physical status I-II, undergoing general anesthesia for elective abdominal surgery were incl...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199607000-00021

    authors: Pueyo FJ,Carrascosa F,Lopez L,Iribarren MJ,García-Pedrajas F,Saez A

    更新日期:1996-07-01 00:00:00

  • A comparison of the antinociceptive and behavioral effects of intrathecally administered opiates, alpha-2-adrenergic agonists, and local anesthetics in mice and rats.

    abstract::This study was undertaken to compare the antinociceptive and behavioral effects of intrathecally administered opiates, alpha-2-adrenergic agonists, and local anesthetics injected by lumbar puncture in the mouse and rat. Antinociception was determined by observing the response to a clamp applied to the tail (Haffner te...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Ossipov MH,Suarez LJ,Spaulding TC

    更新日期:1988-07-01 00:00:00

  • Sevoflurane inhibited beta-adrenoceptor-G protein bindings in myocardial membrane in rats.

    abstract::The effects of sevoflurane on the beta-adrenoceptor (beta AR) system, consisting of the receptor, stimulatory guanosine triphosphate (GTP) binding protein (Gs), and adenylate cyclase (AC), were studied in rat myocardial membrane. Cyclic adenosine monophosphate (cAMP) production rate was measured as cAMP generation sti...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199409000-00011

    authors: Sanuki M,Yuge O,Kawamoto M,Fujii K,Azuma T

    更新日期:1994-09-01 00:00:00

  • Comparative hemodynamic depression of halothane versus isoflurane in neonates and infants: an echocardiographic study.

    abstract::The purpose of this study was to measure and compare the relationship of cardiovascular depression and dose during equal potent levels of halothane and isoflurane anesthesia in neonates (n = 19) (16.7 +/- 6.9 days) and infants (n = 54) (6.1 +/- 3.1 mo). Seventy-three children had heart rate, arterial blood pressure, a...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199203000-00003

    authors: Murray DJ,Forbes RB,Mahoney LT

    更新日期:1992-03-01 00:00:00

  • Hypercapnia improves tissue oxygenation in morbidly obese surgical patients.

    abstract::Risk of wound infection is increased in morbidly obese surgical patients, in part because a major determinant of wound infection risk, tissue oxygenation, is marginal. Unlike in lean patients, supplemental inspired oxygen (Fio2) only slightly improves tissue oxygenation in obese patients. Mild hypercapnia improves tis...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000229715.71464.90

    authors: Hager H,Reddy D,Mandadi G,Pulley D,Eagon JC,Sessler DI,Kurz A

    更新日期:2006-09-01 00:00:00

  • A comparison of the effect on dispersion of repolarization of age-adjusted MAC values of sevoflurane in children.

    abstract:BACKGROUND:QT interval prolongation is associated with torsades des pointes (TdP), but is a poor predictor of drug torsadogenicity. Susceptibility to TdP arises from increased transmural dispersion of repolarization (TDR) across the myocardial wall, rather than QT interval prolongation per se. TDR can be measured on th...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000252417.23986.6e

    authors: Whyte SD,Sanatani S,Lim J,Booker PD

    更新日期:2007-02-01 00:00:00