Pathways of neuron-astrocyte interactions and their possible role in neuroprotection.

abstract：OBJECTIVE:Several predictors of Alzheimer's disease (AD) have been identified. However, the relevance and independent contribution of risk factors and of possible early signs such as mild cognitive impairment and subjective memory impairment on the development of AD has not been investigated prospectively in a cohort o...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Heun R,Kölsch H,Jessen F

更新日期：2006-02-01 00:00:00

abstract：:Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2-/- mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged th...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kronenberg G,Petermann M,Dormann C,Bader M,Gass P,Hellweg R,Klempin F

更新日期：2018-12-01 00:00:00

abstract：:The Trial Criteria in Schizophrenia Working Group was convened in November 2007 to define consensus criteria for clinical trials in patients suffering from acute schizophrenia with special focus on placebo-controlled trials and withdrawal conditions. Clinical trials involving patients give rise to ethical and medico-l...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Riedel M,Leucht S,Rüther E,Schmauß M,Möller HJ

更新日期：2012-03-01 00:00:00

abstract：:Diagnostic checklists for the assessment of DSM-III-R Axis I diagnoses have proven to be a reliable and feasible instrument in research and routine clinical care. Therefore, a checklist for the assessment of the DSM-III-R Personality Disorders (MDCL-P) has been developed. An English version of the MDCL-P is available....

journal_title：European archives of psychiatry and clinical neuroscience

authors： Bronisch T,Garcia-Borreguero D,Flett S,Wolf R,Hiller W

更新日期：1992-01-01 00:00:00

abstract：:In clinical trials in psychiatry, changes in severity are usually measured with ordinal level scales which are applied repeatedly during the trial, showing a constant decline in psychopathology scores as treatment leads to improvement. Previous non-parametric tests for repeated measures in factorial designs did not te...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Bandelow B,Brunner E,Beinroth D,Pralle L,Broocks A,Hajak G,Rüther E

更新日期：1999-01-01 00:00:00

abstract：:MAOA and, to a lesser extent, MAOB polymorphisms have been related to aggression traits and suicidality. We aimed to investigate the role of MAOA and MAOB in suicidal versus non-suicidal participants and interactions between genetic variation and suicidal status on aggression and anger-related traits. The sample was c...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Antypa N,Giegling I,Calati R,Schneider B,Hartmann AM,Friedl M,Konte B,Lia L,De Ronchi D,Serretti A,Rujescu D

更新日期：2013-08-01 00:00:00

abstract：:Savoxepine, an atypical neuroleptic compound developed in the 1980s, was believed to act via selective limbic dopamine D(2)-receptor blockade. The results of the presented double-blind, randomised, controlled clinical trial comparing savoxepine (n = 58) with haloperidol (n = 29) did not confirm the preclinical data su...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Volz HP,Möller HJ,Gerebtzoff A,Bischoff S

更新日期：2002-04-01 00:00:00

abstract：:Proof of efficacy of a psychotropic medicinal product is the key point of clinical psychopharmacology. This especially concerns the licensing of a new compound, but apart from this special case, lots of efficacy questions need to be answered in clinical psychopharmacology, such as, e.g. the question of the efficacy of...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Möller HJ,Broich K

更新日期：2010-02-01 00:00:00

abstract：:Depressive disorders are influenced by a complex interplay between genetic and environmental factors. Multiple studies support a role of serotonergic pathways in the pathophysiology of depressive disorders. As a rate-limiting enzyme of serotonin synthesis in the brain, tryptophan hydroxylase 2 (TPH2) represents a plau...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Van der Auwera S,Janowitz D,Schulz A,Homuth G,Nauck M,Völzke H,Rose M,Meyer zu Schwabedissen H,Freyberger HJ,Grabe HJ

更新日期：2014-11-01 00:00:00

abstract：:To improve recognition and treatment of depression in primary care it would be advantageous to have criteria for identification of later depression. Only a few studies were performed on primary care samples to examine risk factors for new depressive episodes. These were mostly cross-sectional and did not include psych...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Barkow K,Heun R,Ustün TB,Maier W

更新日期：2001-01-01 00:00:00

abstract：:Impairments in emotion recognition and psychosocial functioning are a robust phenomenon in schizophrenia and may affect motivational behavior, particularly during socio-emotional interactions. To characterize potential deficits and their interplay, we assessed social motivation covering various facets, such as implici...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Radke S,Pfersmann V,Derntl B

更新日期：2015-10-01 00:00:00

abstract：:Decreased availability of serotonin in the central nervous system has been suggested to be a central factor in the pathogenesis of depression. Activation of indoleamine 2-3 dioxygenase following a pro-inflammatory state could reduce the amount of tryptophan converted to serotonin and increase the production of tryptop...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Poletti S,Myint AM,Schüetze G,Bollettini I,Mazza E,Grillitsch D,Locatelli C,Schwarz M,Colombo C,Benedetti F

更新日期：2018-03-01 00:00:00

abstract：:Accelerated repetitive transcranial magnetic stimulation (rTMS) protocols are being increasingly studied because of their potential to provide quicker and enhanced treatment efficacy. However, there is a lack of accelerated deep TMS with H1-coil (adTMS) treatment research. This randomized pilot study investigated the ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Filipčić I,Šimunović Filipčić I,Sučić S,Milovac Ž,Gereš N,Matić K,Čelić-Ružić M,Zečević Penić S,Orgulan I,Požgaj V,Bajić Ž

更新日期：2020-05-24 00:00:00

abstract：:The aim of the study was to explore whether the individual burden of ADHD is the same in the elderly as in younger ages even though the symptomatological impact of ADHD seems to remain stable over the lifespan. To assess ADHD symptoms and ADHD-associated problems in daily life, standardised questionnaires were conduct...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Philipp-Wiegmann F,Retz-Junginger P,Retz W,Rösler M

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:We tested Kraepelin's dichotomy model by studying the separability of schizophrenia and depression on the basis of symptoms and illness course. MATERIALS AND METHODS:Matched untreated patients with schizophrenia and depression (n = 130 each) and 130 "healthy" controls were assessed from onset to first admiss...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Häfner H,an der Heiden W,Maurer K

更新日期：2008-06-01 00:00:00

abstract：:In recent studies, the glutamate (Glu) level has been quantified using the modified STEAM sequence on 3T MRI. We enrolled 15 healthy volunteers and a group of 51 patients who experienced stroke for the first time and had a good prognosis. The patients with infarction were divided into three groups according to their s...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Wang X,Li YH,Li MH,Lu J,Zhao JG,Sun XJ,Zhang B,Ye JL

更新日期：2012-02-01 00:00:00

abstract：:One important symptom of patients with major depressive disorder (MDD) is memory dysfunction. However, little is known about the relationship between memory performance and depression severity, about the course of memory performance during antidepressant treatment as well as about the relationship between memory perfo...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Engelmann J,Wagner S,Wollschläger D,Kaaden S,Schlicht KF,Dreimüller N,Braus DF,Müller MB,Tüscher O,Frieling H,Tadić A,Lieb K

更新日期：2020-03-01 00:00:00

abstract：:Comorbid disorders are common in psychiatric diseases and understanding the risk of secondary diseases can aid successful clinical treatment. The objective of this study was to compare the frequency of comorbid dementia, affective disorders, and inflammatory polyarthropathies. Healthcare data obtained via the German H...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Vogelgsang J,Heßmann P,Wolff-Menzler C,Gyßer S,Müller GA,Wiltfang J

更新日期：2020-03-01 00:00:00

abstract：:Theoretical and empirical models of thought disorder (ThD) were tested through Confirmatory factor analysis (CFA). A sample of 253 DSM-III-R acute schizophrenic patients consecutively admitted was studied. A semistructured interview for schizophrenia was used for diagnosis, and ThD was assessed by means of the Thought...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Cuesta MJ,Peralta V

更新日期：1999-01-01 00:00:00

abstract：:In electroconvulsive therapy (ECT), remifentanil is often used concurrently with anesthetics. The objective of this study was to provide an up-to-date and comprehensive review on how the addition of remifentanil to anesthetics affects seizure duration and circulatory dynamics in mECT. We performed a meta-analysis of R...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Takekita Y,Suwa T,Sunada N,Kawashima H,Fabbri C,Kato M,Tajika A,Kinoshita T,Furukawa TA,Serretti A

更新日期：2016-12-01 00:00:00

abstract：:Suicide is a tremendous threat to global public health, and a large number of people who committed suicide suffered the pain of mental diseases, especially major depressive disorder (MDD). Previous study showed that ketamine could reduce suicidal ideation (SI), potentially by improving the impaired working memory (WM)...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Chen X,Wang M,Hu Y,Zhan Y,Zhou Y,Zheng W,Liu W,Wang C,Zhong X,Li H,Lan X,Ning Y,Zhang B

更新日期：2021-01-01 00:00:00

abstract：:Three adult schizophrenic patients without a previous history of epilepsy are reported who, during clozapine treatment, developed paroxysmal EEG patterns and generalized myoclonic jerks without alteration of consciousness. These seizures were phenomenologically identical to those occurring in juvenile myoclonic epilep...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Gouzoulis E,Grunze H,von Bardeleben U

更新日期：1991-01-01 00:00:00

abstract：:Anger is a common and potentially destructive emotion that has considerable social and public health importance. The occurrence of anger, irritability and hostility in depression have been known for many years, but the prevalence, significance for treatment and prognosis and the mechanisms involved remain poorly under...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Painuly N,Sharan P,Mattoo SK

更新日期：2005-08-01 00:00:00

abstract：:Circadian rhythm disturbance is highly prevalent in attention deficit hyperactivity disorder (ADHD). Recently, the association between the CLOCK gene and ADHD has been demonstrated in clinical samples, and the CLOCK gene's role was thought to be mediated by rhythm dysregulation. Meanwhile, ADHD has been suggested as t...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Jeong SH,Yu JC,Lee CH,Choi KS,Choi JE,Kim SH,Joo EJ

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Interpersonal psychotherapy (IPT) is a time-limited psychotherapy for major depression. The aim of this study is to summarize findings from controlled trials of the efficacy of IPT in the treatment of depressive spectrum disorders (DSD) using a meta-analytic approach. METHODS:Studies of randomized clinical t...

journal_title：European archives of psychiatry and clinical neuroscience

authors： de Mello MF,de Jesus Mari J,Bacaltchuk J,Verdeli H,Neugebauer R

更新日期：2005-04-01 00:00:00

abstract：:The aim of this study was to estimate the prevalence and incidence of mood disorders, anxiety disorders, and stress and adjustment disorders in primary health care in Sweden and to analyse the relationship between socioeconomic and demographic factors and incidence of these disorders. Prevalence and incidence data on ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Lejtzén N,Sundquist J,Sundquist K,Li X

更新日期：2014-04-01 00:00:00

abstract：:Ego-disturbances (passivity phenomena) and formal thought disorder are two hallmark symptoms of schizophrenia. Formal thought disorder has been highlighted already very early by Eugen Bleuler in his concept of basic symptoms (Grundsymptome). In contrast ego-disturbances (Ich-Störungen) or passivity phenomena have been...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Leube D,Whitney C,Kircher T

更新日期：2008-11-01 00:00:00

abstract：:Two sisters with muscular dystrophy of Becker-like clinical features presented. Muscle weakness was most prominent in the pelvic girdle, but in the elder sister the distal muscles of the lower extremities were also affected. The progression was different in the siblings: The older sister showed a more pronounced deter...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Diószeghy P,Molnár M,Mechler F

更新日期：1995-01-01 00:00:00

abstract：:The excitatory amino acid glutamate plays an important role in the mammalian CNS. Studies conducted from 1940 to 1950 suggested that oral administration of glutamate could have a beneficial effect on normal and retardate intelligence. The neurotoxic nature of glutamate resulting in excitotoxic lesions (neuronal death)...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Sahai S

更新日期：1990-01-01 00:00:00

abstract：:Evidence suggests that the anterior cingulate cortex (ACC) plays a key role in the development of posttraumatic stress disorder (PTSD). Owing to the region's highly variable patterns, three different studies of PTSD have yielded inconsistent volume reductions. Accordingly, in order to measure the correct borders and v...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Jatzko A,Vogler C,Demirakca T,Ruf M,Malchow B,Falkai P,Braus DF,Ende G,Schmitt A

更新日期：2013-10-01 00:00:00