Abstract：
:Despite surgery, post-operative irradiation and adjuvant conventional chemotherapy, prognosis of high-grade gliomas remains poor. Carmustine (BCNU) has been shown to have limited activity at conventional dosage but is still the standard chemotherapy. Activity of chemotherapy is limited by the blood-brain barrier impermeability and high levels of expression of multidrug resistance proteins on tumor and/or endothelial cells. Despite high response rates, development of intra-arterial chemotherapy remains limited because of frequent acute brain toxicity related to drug administration. High-dose intravenous chemotherapy rescued by autologous hemopoietic stem cell transplantation is an alternative that might increase drug delivery through the blood-brain barrier and tumor control. Several phase I-II trials using high-dose BCNU were published. The maximum tolerated dose seems to be 800 mg/m2 and interstitial pneumonitis and hepatitis are dose-limiting toxicities. Few phase I-II trials of high-dose therapy were published using drug combinations. High response rates in patients with progressive tumor were observed and in adjuvant setting, encouraging results in terms of median survival time and long survivors were published. No phase III trial was reported to date. Future investigations should include randomized trials comparing high-dose and conventional-dose chemotherapy and development of new high-dose regimens that incorporate new drugs such as temozolomide.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Linassier C,Destrieux C,Benboubker L,Alcaraz L,Bergemer-Fouquet AM,Jan M,Calais G,Colombat Psubject
Has Abstractpub_date
2001-09-01 00:00:00pages
871-6issue
9eissn
0007-4551issn
1769-6917journal_volume
88pub_type
杂志文章,评审abstract：:Results from case-control studies and prospective studies suggest that diet is involved in the causation of large bowel cancer either as initiator, promoter or inhibitor of carcinogenesis. Available data are not sufficient to serve as a basis for firm specific dietary advice. In the present situation it is attractive ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：:The great majority of breast cancer cases are not associated with a mutated gene of high penetrance such as BRCA1, BRCA2 and TP53. Genes of low penetrance, frequently mutated in the general population, might play an important role in breast cancer development. The ATM gene, which encodes the ATM protein, mutated in th...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2001-07-01 00:00:00
abstract：:In 2002, new developments in anti-angiogenic strategies encompassed two main aspects. Firstly, essential improvements were made in the field of methodology : novel techniques permitted to measure directly on patients the biological effects induced by anti-angiogenic treatments in the course of clinical trials. Secondl...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to explore the risk factors that were associated with central lymph node metastasis (CLNM) in patients with clinical nodal negative differentiated thyroid carcinoma (cN0 DTC) after prophylactic central neck dissection (pCND). The influence of pCND on TNM staging and recurrence ri...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2016.04.003
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVES:To evaluate the impact of [(18)F]-FDG PET/CT image fusion in the management of carcinomas of the upper aero-digestive tract. METHODS:This retrospective study included 169 patients with squamous cell cacinoma of the upper aerodigestive tract who underwent a PET/CT for : initial staging (n = 47), cervical lym...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:Depression is an important symptom for many palliative care patients but is rarely identified. It's known to reduce quality of life and impact on palliation of physical symptom. These physical symptoms can be improved by an adequate treatment of depression. Many depressed cancer patients are not treated due ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2011.1310
更新日期：2011-02-01 00:00:00
abstract：:Recommendations for the management of gastrointestinal stromal tumours (GIST) in children and adolescents do presently not exist. Thus, a summary of the current literature was conducted serving as a basis for the development of optimal management strategies for childhood GIST. Pediatric cases of GIST may occur sporadi...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1296
更新日期：2011-01-01 00:00:00
abstract：:The radiobiological properties of the hadrons (neutrons, protons, carbon ions) led to their therapeutic use in sarcomas, as a referent therapy or as an alternative to photon therapy. An extensive review of the literature has been conducted to assess the present indications and the perspectives for hadrontherapy. Compa...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1125
更新日期：2010-06-01 00:00:00
abstract：:Perioperative chemotherapy for gastric cancer is validated by two phase III studies. The impact of the preoperative neoadjuvant sequence is probably major in the benefit of this treatment. This chemotherapy increases the R0 resection without increasing either morbidity or mortality. Furthermore, it reduces local and s...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1287
更新日期：2011-01-01 00:00:00
abstract：:Taxoids and platinum derivatives display a true activity against many types of solid tumors. Their relatively non overlapping toxicity profiles and their different mechanisms of action made their combination attractive. Actually, the frequency and the severity of the toxicity appeared schedule-dependent. Thus, cisplat...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2000-08-01 00:00:00
abstract：:Doxifluridine, a new fluorouracil analog with a low myelosuppressive effect, has recently been subject to various disease-oriented, Phase II trials. For the present evaluation of drug tolerance, the Phase II data of 114 patients having received 376 doxifluridine cycles has been used. The treatment cycles consisted of ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Genomic DNA displays a non canonical structure prone to be damaged and modified by genotoxic stresses, which are induced either by the endogenous metabolism or attacks from environment or therapeutic pressure. Several molecular pathways allow cells to repair such DNA lesions. Additional mechanisms have been selected t...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1202
更新日期：2010-11-01 00:00:00
abstract：:Gemcitabine has demonstrated a good efficacy in number of tumor types. Thanks to its favourable toxicity profile, gemcitabine can be used in combination with a number of drugs. Single agent gemcitabine and gemcitabine-based combinations have been evaluated in metastatic breast cancer. Some of these combinations, such ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2002-08-01 00:00:00
abstract：:The biological diagnosis of prostatic carcinoma in relation with benign prostatic hypertrophy is essentially realized by the evaluation of plasma PAP or medullar PAP, the increase of which rises to 70% of the cases. This evaluation contains also other biochemical markers such as CK-BB, glucose-6-phosphate dehydrogenas...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Important improvements in local control with increasing function-sparing treatment have been achieved in adult soft tissue sarcomas (STS). However, the global prognosis of these diseases remains poor and 40% of patients with STS currently die of metastases within 5 years. In fact, the impact of chemotherapy remains de...
journal_title：Bulletin du cancer
pub_type： 杂志文章,meta分析
doi：
更新日期：1997-06-01 00:00:00
abstract：:The evolution of anti-cancer chemotherapy has led to long duration treatments, which preferentially are given at home, with the participation of the general practitionner (G.P.). The indications and general supervision of these belong to the oncologist, so thus necessitates a coordinated effort between the many physic...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Neoadjuvant chemoradiotherapy is considered at the present time as the standard treatment of most T3-4 rectal cancer. In France a combination of radiotherapy (45 Gy/5 weeks) with concurrent capecitabine (1,600 mg/m2) is the most popular protocol. Randomized trials try to optimize this approach using new cytotoxic drug...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2009.0838
更新日期：2009-03-01 00:00:00
abstract：:The aim of this review is to discuss the different communication skills training designed to physician interactions with cancer patients. The development of medicine and chronic cancer treatments indicates the need to improve communication skills that combine appropriate assessment, information and support. Literature...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2001-12-01 00:00:00
abstract：:Oncolor, network in oncology in Lorraine, was born ten years ago, from a group of professionals in the field of oncology who worked closed together with regional administrative authorities. Oncolor was created with respect of equilibrium between the different regional partners avoiding struggle for power. Oncolor was ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：:The isotopic detection of the sentinel node is undergoing a fast development in breast cancer and melanoma. It requires a good collaboration between a surgeon and a nuclear medicine specialist. Although the method is now well defined for melanoma, several options remain possible for breast cancer. The injected dose an...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：:Merkel cell carcinoma (MCC) is an uncommon neuro-endocrine tumor of the sun-exposed skin predominantly observed in white patients in the sixth decade of the life. In electron microscopy MCC characteristically contains dense core secretory granules. This tumor expresses both epithelial (keratins of low molecular weight...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1999-07-01 00:00:00
abstract：:Screening methods for the detection of anticancer activity are of crucial importance in order to find solid tumor-specific agents. A review of past screening methods is followed by a description of present methodologies targetted toward the discovery of such agents. Finally, we discuss primary and secondary in vivo ev...
journal_title：Bulletin du cancer
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:Nasopharyngeal carcinoma (NPC) represents one of the most frequent epithelial tumours of the child in intermediate risk regions. In the Maghreb, it represents the first cancer of teenagers of 15-20 years old. The Epstein Barr virus (EBV) is the most important etiologic factor. Its role in the pathogeneses of NPC has b...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2010.1087
更新日期：2010-04-01 00:00:00
abstract：:Radiation induced lymphopenia is frequent and can be severe and durable. Although lymphocytes have long been known as highly radiosensitive cells, it is poorly characterized. Radiation-induced lymphopenia seems to affect lymphocyte subpopulations differently and seems to be influenced by radiation modalities. The dept...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2020.04.009
更新日期：2020-01-01 00:00:00
abstract：:The authors report a case of transformation of a low grade non-Hodgkin's lymphoma (LGL) to an agressive lymphoma in a 55 year-old woman who was treated by fludarabine phosphate. The only sign of transformation was the supervention of an hypercalcemia. This complication is rare in the evolution of the LGL and the mecha...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Hepatocellular carcinoma is the third most frequent cause of cancer death worldwide, particularly in Asia and Africa. Most cases complicate an underlying liver cirrhosis due to hepatitis B or C chronic virus infection or alcoholic abuse. But, following the current epidemics of obesity and type 2 diabetes, it appears t...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2018.02.003
更新日期：2018-05-01 00:00:00
abstract：:The relationships involved in host resistance to tumor development were studied. Animals were pretreated by local hyperthermia, local irradiation and combined local hyperthermia and x-irradiation. After treatment, the animals were inoculated with tumor cells 0--96 or 0--120 hours post treatment. (BALB/c X C57B1/6)F1 m...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:The retrospective evaluation of the dose after an irradiation accident is of paramount importance; it allows an adequate selection of patients and the most appropriate treatment can then be proposed. Classical physical dosimetry often lacks precision for dose assessment in such accidents. Cytogenetics, usually more re...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:We have previously shown that the addition of 4-methylthio-2-oxobutanoate (MTOB) to cultures of methionine dependent neoplastic cells which lack endogenous MTOB restores their capacity to grow in the absence of exogenous methionine. Transition state inhibitors of the MTOB transaminase,responsible for the transaminatio...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
abstract：:This article briefly outlines three major biochemical problems in relation to the presence of chemical carcinogens in mammalian cells: (a) the enzymatic systems responsible for the chemical carcinogen metabolism; (b) the nature of the reactive metabolites and (c) the cellular target(s). References and examples are onl...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
