Use of a density equalizing map projection in analysing childhood cancer in four California counties.

abstract：:Sensible plans for health-care needs and determination of priorities for expenditure require regular assessment of trends in HIV incidences. In particular, trends in the relative HIV incidences of different risk categories are useful when assessing whether current control strategies are working equally well for all ri...

journal_title：Statistics in medicine

authors： Becker NG,Cui JS

更新日期：1996-08-30 00:00:00

abstract：:Technologic advances give rise to new tests for detecting disease in many fields, including cancer and sexually transmitted disease. Before a new disease screening test is approved for public use, its accuracy should be shown to be better than or at least not inferior to an existing test. Standards do not yet exist fo...

journal_title：Statistics in medicine

authors： Alonzo TA,Pepe MS,Moskowitz CS

更新日期：2002-03-30 00:00:00

abstract：:In this paper, an approach to estimating the cumulative mean function for history process with time dependent covariates and right censored time-to-event variable is developed using the combined technique of joint modeling and inverse probability weighting method. The consistency of proposed estimator is derived. Theo...

journal_title：Statistics in medicine

authors： Deng D

更新日期：2016-11-10 00:00:00

abstract：:There is growing interest in how best to adapt and readapt treatments to individuals to maximize clinical benefit. In response, adaptive treatment strategies (ATS), which operationalize adaptive, sequential clinical decision making, have been developed. From a patient's perspective an ATS is a sequence of treatments, ...

journal_title：Statistics in medicine

authors： Almirall D,Compton SN,Gunlicks-Stoessel M,Duan N,Murphy SA

更新日期：2012-07-30 00:00:00

abstract：:For time-to-event outcomes, a rich literature exists on the bias introduced by covariate measurement error in regression models, such as the Cox model, and methods of analysis to address this bias. By comparison, less attention has been given to understanding the impact or addressing errors in the failure time outcome...

journal_title：Statistics in medicine

authors： Oh EJ,Shepherd BE,Lumley T,Shaw PA

更新日期：2018-04-15 00:00:00

abstract：:Meta-analyses pooling continuous outcomes can use mean differences (MD), standardized MD (MD in pooled standard deviation units, SMD), or ratio of arithmetic means (RoM). Recently, ratio of geometric means using ad hoc (RoGM (ad hoc) ) or Taylor series (RoGM (Taylor) ) methods for estimating variances have been propos...

journal_title：Statistics in medicine

authors： Friedrich JO,Adhikari NK,Beyene J

更新日期：2012-07-30 00:00:00

abstract：:There is a single-minded focus on events in survival analysis, and we often ignore longitudinal data that are collected together with the event data. This is due to a lack of methodology but also a result of the artificial distinction between survival and longitudinal data analyses. Understanding the dynamics of such ...

journal_title：Statistics in medicine

authors： Aalen OO

更新日期：2012-08-15 00:00:00

abstract：:In this paper, we argue that causal effect models for realistic individualized treatment rules represent an attractive tool for analyzing sequentially randomized trials. Unlike a number of methods proposed previously, this approach does not rely on the assumption that intermediate outcomes are discrete or that models ...

journal_title：Statistics in medicine

authors： Bembom O,van der Laan MJ

更新日期：2008-08-30 00:00:00

abstract：:Logistic regression analysis may well be used to develop a prognostic model for a dichotomous outcome. Especially when limited data are available, it is difficult to determine an appropriate selection of covariables for inclusion in such models. Also, predictions may be improved by applying some sort of shrinkage in t...

journal_title：Statistics in medicine

authors： Steyerberg EW,Eijkemans MJ,Harrell FE Jr,Habbema JD

更新日期：2000-04-30 00:00:00

abstract：:In many studies, a K degree of freedom large sample chi2 test is used to assess the effect of treatment on a multivariate response, such as an omnibus T2-like test of a difference between two treatment groups in any of K repeated measures. Alternately, a K df chi2 test may be used to test the equality of K+1 groups in...

journal_title：Statistics in medicine

authors： Lachin JM,Greenhouse SW,Bautista OM

更新日期：2003-11-15 00:00:00

abstract：:Predicting an individual's risk of experiencing a future clinical outcome is a statistical task with important consequences for both practicing clinicians and public health experts. Modern observational databases such as electronic health records provide an alternative to the longitudinal cohort studies traditionally ...

journal_title：Statistics in medicine

authors： Wolfson J,Bandyopadhyay S,Elidrisi M,Vazquez-Benitez G,Vock DM,Musgrove D,Adomavicius G,Johnson PE,O'Connor PJ

更新日期：2015-09-20 00:00:00

abstract：:Hospital length of stay (LOS) is an important measure of healthcare utilization and is generally positively skewed and heterogeneous. We fit a Coxian phase-type distribution to LOS and identify the hidden states of the underlying latent homogeneous Markov model. We demonstrate that selecting an appropriate number of p...

journal_title：Statistics in medicine

authors： Tang X,Luo Z,Gardiner JC

更新日期：2012-06-30 00:00:00

abstract：:Many observational studies adopt what we call retrospective convenience sampling (RCS). With the sample size in each arm prespecified, RCS randomly selects subjects from the treatment-inclined subpopulation into the treatment arm and those from the control-inclined into the control arm. Samples in each arm are represe...

journal_title：Statistics in medicine

authors： Hu Z,Qin J

更新日期：2018-05-20 00:00:00

abstract：:The generalized estimating equations (GEE) approach is commonly used to model incomplete longitudinal binary data. When drop-outs are missing at random through dependence on observed responses (MAR), GEE may give biased parameter estimates in the model for the marginal means. A weighted estimating equations approach g...

journal_title：Statistics in medicine

authors： Preisser JS,Lohman KK,Rathouz PJ

更新日期：2002-10-30 00:00:00

abstract：:A good measure of field vaccine efficacy should evaluate the direct protective effect of vaccination on the person who receives the vaccine. The conventional estimator for vaccine efficacy depends on population level factors that are either unrelated or indirectly related to the direct biological action of the vaccine...

journal_title：Statistics in medicine

authors： Longini IM Jr,Halloran ME,Haber M,Chen RT

更新日期：1993-02-01 00:00:00

abstract：:In cancer clinical trials, patients often experience a recurrence of disease prior to the outcome of interest, overall survival. Additionally, for many cancers, there is a cured fraction of the population who will never experience a recurrence. There is often interest in how different covariates affect the probability...

journal_title：Statistics in medicine

authors： Conlon AS,Taylor JM,Sargent DJ

更新日期：2014-05-10 00:00:00

abstract：:Many complex diseases are known to be affected by the interactions between genetic variants and environmental exposures beyond the main genetic and environmental effects. Study of gene-environment (G×E) interactions is important for elucidating the disease etiology. Existing Bayesian methods for G×E interaction studie...

journal_title：Statistics in medicine

authors： Ren J,Zhou F,Li X,Chen Q,Zhang H,Ma S,Jiang Y,Wu C

更新日期：2020-02-28 00:00:00

abstract：:This paper describes the Stoke Index which has been designed to give a global measure of disease activity in rheumatoid arthritis. The index is based on two objective laboratory measurements, one subjective and two semi-objective clinical measurements, chosen from 13 measurements using clinical judgement. Variable sel...

journal_title：Statistics in medicine

authors： Jones PW,Ziade MF,Davis MJ,Dawes PT

更新日期：1993-06-30 00:00:00

abstract：:Many studies have reported large variations in age- and sex-adjusted rates of hospitalizations across small geographic areas. These variations have often been attributed to differences in medical practice style which are not reflected in differences in health care outcomes. There is, however, another potentially impor...

journal_title：Statistics in medicine

authors： Peköz EA,Shwartz M,Iezzoni LI,Ash AS,Posner MA,Restuccia JD

更新日期：2003-05-30 00:00:00

abstract：:In population-based case-control studies, an attempt is made to identify all incident cases diagnosed in a specified population during a fixed time interval. Assuming that this goal is met allows one to obtain measures of risk other than relative risks. In this paper, we describe three approaches to estimate exposure-...

journal_title：Statistics in medicine

authors： Benichou J,Wacholder S

更新日期：1994-03-15 00:00:00

abstract：:In biomedical research such as the development of vaccines for infectious diseases or cancer, study outcomes measured by an assay or device are often collected from multiple sources or laboratories. Measurement error that may vary between laboratories needs to be adjusted for when combining samples across data sources...

journal_title：Statistics in medicine

authors： Huang Y,Huang Y,Moodie Z,Li S,Self S

更新日期：2012-12-10 00:00:00

abstract：:Drop-out often occurs in clinical trials with multiple visits and drop-out is often informative in the sense that the population of patients who dropped out is different from the population of patients who completed the study. To handle data with informative drop-out, an intention-to-treat analysis, which evaluates tr...

journal_title：Statistics in medicine

authors： Shao J,Zhong B

更新日期：2003-08-15 00:00:00

abstract：:Statistical methods for analyzing recurrent events have attracted significant attention. The majority of existing works consider situations in which subjects are observed over time periods and events of interest that occurred during the course of follow-up are recorded. In some applications, a subject may leave the st...

journal_title：Statistics in medicine

authors： Su PF,Zhong J,Ou HT

更新日期：2019-04-15 00:00:00

abstract：:We propose a new design for dose finding for cytotoxic agents in two ordered groups of patients. By ordered groups, we mean that prior to the study there is clinical information that would indicate that for a given dose one group would be more susceptible to toxicities than patients in the other group. The designs are...

journal_title：Statistics in medicine

authors： Conaway MR,Wages NA

更新日期：2017-01-30 00:00:00

abstract：:We develop analysis methods for clinical trials with time-to-event outcomes which correct for treatment changes during follow-up, yet are based on comparisons of randomized groups and not of selected groups. A causal model relating observed event times to event times that would have been observed under other treatment...

journal_title：Statistics in medicine

authors： White IR,Babiker AG,Walker S,Darbyshire JH

更新日期：1999-10-15 00:00:00

abstract：:For bivariate meta-analysis of diagnostic studies, likelihood approaches are very popular. However, they often run into numerical problems with possible non-convergence. In addition, the construction of confidence intervals is controversial. Bayesian methods based on Markov chain Monte Carlo (MCMC) sampling could be u...

journal_title：Statistics in medicine

authors： Paul M,Riebler A,Bachmann LM,Rue H,Held L

更新日期：2010-05-30 00:00:00

abstract：:Suppression of premature ventricular contractions (PVCs) is one of the goals of antiarrhythmic therapy. In a clinical trial, however, it may be difficult to distinguish antiarrhythmic drug effect from spontaneous variation in PVCs. We propose the application of linear regression to PVC histories to ascertain drug effe...

journal_title：Statistics in medicine

authors： Berry DA,Fox TL

更新日期：1983-07-01 00:00:00

abstract：:Teaching statistics to medical students is a challenging and often unrewarding task. However, few would argue the need for statistics in the medical school curriculum. In recent years, there has been a growing call for teaching only statistical concepts in medical schools. We strongly oppose this opinion and offer an ...

journal_title：Statistics in medicine

authors： Herman A,Notzer N,Libman Z,Braunstein R,Steinberg DM

更新日期：2007-10-15 00:00:00

abstract：:This paper presents a general approach for simultaneously assessing, from serial data, diagnostic consistency, interrater reliability and incidence of a strictly progressive disease. Observed data are viewed as incomplete: diagnostic errors are not distinguished from true diagnoses. We introduce a broad class of model...

journal_title：Statistics in medicine

authors： Espeland MA,Murphy WC,Leverett DH

更新日期：1988-03-01 00:00:00

abstract：:The continual reassessment method (CRM) is an adaptive design for Phase I trials whose operating characteristics, including appropriate sample size, probability of correctly identifying the maximum tolerated dose, and the expected proportion of participants assigned to each dose, can only be determined via simulation....

journal_title：Statistics in medicine

authors： Braun TM

更新日期：2020-09-16 00:00:00