A comparison of three approaches to estimate exposure-specific incidence rates from population-based case-control data.

Abstract:

:In population-based case-control studies, an attempt is made to identify all incident cases diagnosed in a specified population during a fixed time interval. Assuming that this goal is met allows one to obtain measures of risk other than relative risks. In this paper, we describe three approaches to estimate exposure-specific incidence rates. Approach 1 relies on estimating crude incidence rates of the disease in strata defined, for instance, by age and geographic area, and combining them with relative risk estimates from the case-control data. In approaches 2 and 3, baseline incidence rates and relative risks are estimated jointly. Approach 2 is based on a pseudo-likelihood, while, in approach 3, the problem is regarded as a missing data problem and a full likelihood is maximized. We applied these three approaches to a study of bladder cancer. Our three sets of estimates of exposure-specific incidence rates were in close agreement, while there appeared to be greater precision with approaches 2 and 3.

journal_name

Stat Med

journal_title

Statistics in medicine

authors

Benichou J,Wacholder S

doi

10.1002/sim.4780130526

subject

Has Abstract

pub_date

1994-03-15 00:00:00

pages

651-61

issue

5-7

eissn

0277-6715

issn

1097-0258

journal_volume

13

pub_type

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