Semiparametric Bayesian variable selection for gene-environment interactions.

abstract：:During phase III clinical trials in life-threatening disease settings, it is important to ensure that the Data Monitoring Committee (DMC) has exclusive access to the interim efficacy and safety data generated by the data analysis centre, in order to minimize the risk of widespread prejudgement of unreliable trial resu...

journal_title：Statistics in medicine

authors： Fleming TR,Ellenberg S,DeMets DL

更新日期：2002-10-15 00:00:00

abstract：:Many models for clinical prediction (prognosis or diagnosis) are published in the medical literature every year but few such models find their way into clinical practice. The reason may be that since in most cases models have not been validated in independent data, they lack generality and/or credibility. In this pape...

journal_title：Statistics in medicine

authors： Royston P,Parmar MK,Sylvester R

更新日期：2004-03-30 00:00:00

abstract：:Phase II studies in oncology are frequently conducted as two-stage single-arm trials with a binary endpoint indicating tumor response. As a common feature of these designs, the sample sizes of the two stages and the decision rules for the interim and the final analysis have to be pre-specified and adhered to strictly ...

journal_title：Statistics in medicine

authors： Englert S,Kieser M

更新日期：2015-06-15 00:00:00

abstract：:Optimal prevention and treatment strategies for a disease of multiple causes, such as pneumonia, must be informed by the population distribution of causes among cases, or cause-specific case fractions (CSCFs). CSCFs may further depend on additional explanatory variables. Existing methodological literature in disease e...

journal_title：Statistics in medicine

authors： Wu Z,Chen I

更新日期：2021-02-20 00:00:00

abstract：:The identification of counties burdened by exceptionally high rates of mortality is a fundamental step in the development of state-based intervention and prevention strategies. However, the estimation of rates from small geographic areas presents special problems, especially for rare events. This paper compares the us...

journal_title：Statistics in medicine

authors： Stevenson JM,Olson DR

更新日期：1993-02-01 00:00:00

abstract：:Clinical trials studying treatments for rare diseases are challenging to design and conduct due to the limited number of patients eligible for the trial. One design used to address this challenge is the small n, sequential, multiple assignment, randomized trial (snSMART). We propose a new snSMART design that investiga...

journal_title：Statistics in medicine

authors： Fang F,Hochstedler KA,Tamura RN,Braun TM,Kidwell KM

更新日期：2021-02-20 00:00:00

abstract：:With considerable current interest in longitudinal epidemiologic studies, little is available regarding sample size requirements. This paper considers a method for analysis of longitudinal data, where one compares the mean rates of change for two or more groups, and proposes a statistic for use in determining sample s...

journal_title：Statistics in medicine

authors： Lefante JJ

更新日期：1990-04-01 00:00:00

abstract：:This paper presents a mixture model which combines features of the usual Cox proportional hazards model with those of a class of models, known as mixtures-of-experts. The resulting model is more flexible than the usual Cox model in the sense that the log hazard ratio is allowed to vary non-linearly as a function of th...

journal_title：Statistics in medicine

authors： Rosen O,Tanner M

更新日期：1999-05-15 00:00:00

abstract：BACKGROUND:It has been recommended that onset of antidepressant action be assessed using survival analyses with assessments taken at least twice per week. However, such an assessment schedule is problematic to implement. The present study assessed the feasibility of comparing onset of action between treatments using a ...

journal_title：Statistics in medicine

authors： Mallinckrodt CH,Detke MJ,Kaiser CJ,Watkin JG,Molenberghs G,Carroll RJ

更新日期：2006-07-30 00:00:00

abstract：:In order for national statistical offices to maintain the trust of the public to collect data and publish statistics of importance to society and decision-making, it is imperative that respondents (persons or establishments) be guaranteed privacy and confidentiality in return for providing requested confidential data....

journal_title：Statistics in medicine

authors： Gonzalez JF Jr,Cox LH

更新日期：2005-02-28 00:00:00

abstract：:The incremental life expectancy, defined as the difference in mean survival times between two treatment groups, is a crucial quantity of interest in cost-effectiveness analyses. Usually, this quantity is very difficult to estimate from censored survival data with a limited follow-up period. The paper develops estimati...

journal_title：Statistics in medicine

authors： Titman AC

更新日期：2016-09-10 00:00:00

abstract：:Novel therapies are challenging the standards of drug development. Agents with specific biologic targets, unknown dose-efficacy curves, and limited toxicity mandate novel designs to identify biologically optimal doses. We review two model-based designs that utilize either a proportional odds model or a continuation ra...

journal_title：Statistics in medicine

authors： Mandrekar SJ,Qin R,Sargent DJ

更新日期：2010-05-10 00:00:00

abstract：:Correlation analysis is widely used in biomedical and psychosocial research for assessing rater reliability, precision of diagnosis and accuracy of proxy outcomes. The popularity of longitudinal study designs has propelled the proliferation in recent years of new methods for longitudinal and other multi-level clustere...

journal_title：Statistics in medicine

authors： Tu XM,Feng C,Kowalski J,Tang W,Wang H,Wan C,Ma Y

更新日期：2007-09-30 00:00:00

abstract：:Virtually all clinical trials collect multiple endpoints that are usually correlated. Many methods have been proposed to control the family-wise type I error rate (FWER), but these methods often disregard the correlation among the endpoints, such as the commonly used Bonferroni correction, Holm procedure, Wiens' Bonfe...

journal_title：Statistics in medicine

authors： Xie C

更新日期：2012-02-20 00:00:00

abstract：:The 'at least as good as' criterion, introduced by Laster and Johnson for a continuous response variate, is developed here for applications with dichotomous data. This approach is adaptive in nature, as the margin of non-inferiority is not taken as a fixed difference; it varies as a function of the positive control re...

journal_title：Statistics in medicine

authors： Laster LL,Johnson MF,Kotler ML

更新日期：2006-04-15 00:00:00

abstract：:A popular method for analysing repeated-measures data is generalized estimating equations (GEE). When response data are missing at random (MAR), two modifications of GEE use inverse-probability weighting and imputation. The weighted GEE (WGEE) method involves weighting observations by their inverse probability of bein...

journal_title：Statistics in medicine

authors： Seaman S,Copas A

更新日期：2009-03-15 00:00:00

abstract：:It is not uncommon for a continuous outcome variable Y to be dichotomized and analysed using logistic regression. Moser and Coombs (Statist. Med. 2004; 23:1843-1860) provide a method for converting the output from a standard linear regression analysis using the original continuous outcome Y to give much more efficient...

journal_title：Statistics in medicine

authors： Jiang Y,Scott A,Wild CJ

更新日期：2009-01-30 00:00:00

abstract：:The problem of testing symmetry about zero has a long and rich history in the statistical literature. We introduce a new test that sequentially discards observations whose absolute value is below increasing thresholds defined by the data. McNemar's statistic is obtained at each threshold and the largest is used as the...

journal_title：Statistics in medicine

authors： Laska E,Meisner M,Wanderling J

更新日期：2012-11-20 00:00:00

abstract：:In randomised trials, continuous endpoints are often measured with some degree of error. This study explores the impact of ignoring measurement error and proposes methods to improve statistical inference in the presence of measurement error. Three main types of measurement error in continuous endpoints are considered:...

journal_title：Statistics in medicine

authors： Nab L,Groenwold RHH,Welsing PMJ,van Smeden M

更新日期：2019-11-30 00:00:00

abstract：:In psychiatry, clinicians use criteria sets from the Diagnostic and Statistical Manual of Mental Disorders to diagnose mental disorders. Most criteria sets have several symptom domains, and in order to be diagnosed, an individual must meet the minimum number of symptoms required by each domain. Some efforts are now fo...

journal_title：Statistics in medicine

authors： Mauro C,Shear MK,Wang Y

更新日期：2019-07-20 00:00:00

abstract：:We describe rank-based approaches to assess principal stratification treatment effects in studies where the outcome of interest is only well-defined in a subgroup selected after randomization. Our methods are sensitivity analyses, in that estimands are identified by fixing a parameter and then we investigate the sensi...

journal_title：Statistics in medicine

authors： Lu X,Mehrotra DV,Shepherd BE

更新日期：2013-11-20 00:00:00

abstract：:Providing personalized treatments designed to maximize benefits and minimizing harms is of tremendous current medical interest. One problem in this area is the evaluation of the interaction between the treatment and other predictor variables. Treatment effects in subgroups having the same direction but different magni...

journal_title：Statistics in medicine

authors： Chen W,Ghosh D,Raghunathan TE,Norkin M,Sargent DJ,Bepler G

更新日期：2012-12-10 00:00:00

abstract：:Sexually transmitted infections (STIs) with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis are among the most common infectious diseases in the United States, disproportionately affecting young women. Because a significant portion of the infections present no symptoms, infection control relies...

journal_title：Statistics in medicine

authors： Li Z,Liu H,Tu W

更新日期：2015-09-10 00:00:00

abstract：:There is considerable public concern about health disparities among different cultural/racial/ethnic groups. Important process measures that might reflect inequities are treated prevalence and the service utilization rate in a defined period of time. We have previously described a method for estimating N, the distinct...

journal_title：Statistics in medicine

authors： Laska EM,Meisner M,Wanderling J,Siegel C

更新日期：2010-07-20 00:00:00

abstract：:This paper discusses regression analysis of multivariate current status failure time data (The Statistical Analysis of Interval-censoring Failure Time Data. Springer: New York, 2006), which occur quite often in, for example, tumorigenicity experiments and epidemiologic investigations of the natural history of a diseas...

journal_title：Statistics in medicine

authors： Chen MH,Tong X,Sun J

更新日期：2009-11-30 00:00:00

abstract：:An important problem in oncology is comparing chemotherapy (chemo) agents in terms of their effects on survival or progression-free survival time. When the goal is to evaluate individual agents, a difficulty commonly encountered with observational data is that many patients receive a chemo combination including two or...

journal_title：Statistics in medicine

authors： Thall PF,Liu DD,Berrak SG,Wolff JE

更新日期：2011-07-10 00:00:00

abstract：:Assessment of quality of life is becoming standard in clinical trials. A popular method for measuring quality of life is with instruments which utilize multiple-item subscales, in which each item is scored on a Likert scale. Most statistical methods for the analysis of quality of life data in clinical trials do not ex...

journal_title：Statistics in medicine

authors： Douglas JA

更新日期：1999-11-15 00:00:00

abstract：:The 'landmark' and 'Simon and Makuch' non-parametric estimators of the survival function are commonly used to contrast the survival experience of time-dependent treatment groups in applications such as stem cell transplant versus chemotherapy in leukemia. However, the theoretical survival functions corresponding to th...

journal_title：Statistics in medicine

authors： Bernasconi DP,Rebora P,Iacobelli S,Valsecchi MG,Antolini L

更新日期：2016-03-30 00:00:00

abstract：:In US states with small subpopulations, the observed mortality rates are often zero, particularly among young ages. Because in life tables, death rates are reported mostly on a log scale, zero mortality rates are problematic. To overcome the observed zero death rates problem, appropriate probability models are used. U...

journal_title：Statistics in medicine

authors： Voulgaraki A,Wei R,Kedem B

更新日期：2015-05-20 00:00:00

abstract：:Despite our best efforts, missing outcomes are common in randomized controlled clinical trials. The National Research Council's Committee on National Statistics panel report titled The Prevention and Treatment of Missing Data in Clinical Trials noted that further research is required to assess the impact of missing da...

journal_title：Statistics in medicine

authors： Cook T,Zea R

更新日期：2020-01-30 00:00:00