Abstract:
:Providing personalized treatments designed to maximize benefits and minimizing harms is of tremendous current medical interest. One problem in this area is the evaluation of the interaction between the treatment and other predictor variables. Treatment effects in subgroups having the same direction but different magnitudes are called quantitative interactions, whereas those having opposite directions in subgroups are called qualitative interactions (QIs). Identifying QIs is challenging because they are rare and usually unknown among many potential biomarkers. Meanwhile, subgroup analysis reduces the power of hypothesis testing and multiple subgroup analyses inflate the type I error rate. We propose a new Bayesian approach to search for QI in a multiple regression setting with adaptive decision rules. We consider various regression models for the outcome. We illustrate this method in two examples of phase III clinical trials. The algorithm is straightforward and easy to implement using existing software packages. We provide a sample code in Appendix A.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Chen W,Ghosh D,Raghunathan TE,Norkin M,Sargent DJ,Bepler Gdoi
10.1002/sim.5429subject
Has Abstractpub_date
2012-12-10 00:00:00pages
3693-707issue
28eissn
0277-6715issn
1097-0258journal_volume
31pub_type
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