Bounds on natural direct effects in the presence of confounded intermediate variables.

Abstract:

:In epidemiological studies we often want to learn about the direct effect of an exposure on an outcome, i.e. the effect that is not relayed by a specific intermediate variable. In the literature, there are two common definitions of direct effects; controlled and natural. When the intermediate variable and the outcome have common causes, neither the controlled nor the natural direct effect is identified. Cai et al. (Biometrics 2007; 64(3):695-701) derived bounds for the controlled direct effect under a set of hierarchical assumptions. In this paper we derive bounds on the natural direct effect under the same assumptions.

journal_name

Stat Med

journal_title

Statistics in medicine

authors

Sjölander A

doi

10.1002/sim.3493

subject

Has Abstract

pub_date

2009-02-15 00:00:00

pages

558-71

issue

4

eissn

0277-6715

issn

1097-0258

journal_volume

28

pub_type

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