An improved algorithm for outbreak detection in multiple surveillance systems.

abstract：:It has been increasingly common to analyze simultaneously repeated measures and time to failure data. In this paper we propose a joint model when the repeated measures are semi-continuous, characterized by the presence of a large portion of zero values, as well as right skewness of non zero (positive) values. Examples...

journal_title：Statistics in medicine

authors： Liu L

更新日期：2009-03-15 00:00:00

abstract：:The development of drugs and biologicals whose mechanisms of action may extend beyond their target indications has led to a need to identify unexpected potential toxicities promptly even while blinded clinical trials are under way. One component of recently issued FDA rules regarding safety reporting requirements rais...

journal_title：Statistics in medicine

authors： Gould AL,Wang WB

更新日期：2017-01-15 00:00:00

abstract：:Having a surrogate for a definitive endpoint in a clinical trial can sometimes be useful when it is impractical, invasive or very time consuming to obtain the definitive endpoint. This paper discusses methods for assessing whether the surrogate-endpoint results of a trial can be used in place of definitive-endpoint re...

journal_title：Statistics in medicine

authors： Korn EL,Albert PS,McShane LM

更新日期：2005-01-30 00:00:00

abstract：:Many randomized clinical trials include a data and safety monitoring board (DSMB) that is responsible for reviewing accruing data, monitoring performance of the trial, assuring safety of the participants in the trial, and assessing the efficacy of treatment. The DSMB often makes recommendations about continuation of t...

journal_title：Statistics in medicine

authors： Wittes J

更新日期：1993-03-01 00:00:00

abstract：:The identification of new adverse drug reactions is often tricky. For a given case, the relationship between drug exposure and symptom occurrence is usually questionable. It could be investigated statistically from a series of drug-event association cases with an independence test between the two variables. Analysing ...

journal_title：Statistics in medicine

authors： Tubert P,Begaud B

更新日期：1991-06-01 00:00:00

abstract：:The design of clinical trials often requires knowledge of quantities such as between- and within subject variances about which only imprecise information exists. To provide assurance that the study has the desired power to detect a minimum clinically meaningful difference between treatment groups. Gould, Gould and Shi...

journal_title：Statistics in medicine

authors： Shih WJ,Gould AL

更新日期：1995-10-30 00:00:00

abstract：:Composite endpoints are frequently used in clinical trials, but simple approaches, such as the time to first event, do not reflect any ordering among the endpoints. However, some endpoints, such as mortality, are worse than others. A variety of procedures have been proposed to reflect the severity of the individual en...

journal_title：Statistics in medicine

authors： Follmann D,Fay MP,Hamasaki T,Evans S

更新日期：2020-02-28 00:00:00

abstract：:The need for resource-intensive laboratory assays to assess exposures in many epidemiologic studies provides ample motivation to consider study designs that incorporate pooled samples. In this paper, we consider the case in which specimens are combined for the purpose of determining the presence or absence of a pool-w...

journal_title：Statistics in medicine

authors： Lyles RH,Tang L,Lin J,Zhang Z,Mukherjee B

更新日期：2012-09-28 00:00:00

abstract：:To study the effect of a mega hydropower dam in southwest Ethiopia on malaria incidence, we have set up a longitudinal study. To gain insight in temporal and spatial aspects, that is, in time (period  =  year-season combination) and location (village), we need models that account for these effects. The frailty model w...

journal_title：Statistics in medicine

authors： Getachew Y,Janssen P,Yewhalaw D,Speybroeck N,Duchateau L

更新日期：2013-08-15 00:00:00

abstract：:In the field of cluster detection, a weighted normal model-based scan statistic was recently developed to analyze regional continuous data and to evaluate the clustering pattern of pre-defined cells (such as state, county, tract, school, hospital) that include many individuals. The continuous measures of interest are,...

journal_title：Statistics in medicine

authors： Huang L,Tiwari RC,Pickle LW,Zou Z

更新日期：2010-10-15 00:00:00

abstract：:Clinical trials often assess efficacy by comparing treatments on the basis of two or more event-time outcomes. In the case of cancer clinical trials, progression-free survival (PFS), which is the minimum of the time from randomization to progression or to death, summarizes the comparison of treatments on the hazards f...

journal_title：Statistics in medicine

authors： Finkelstein DM,Schoenfeld DA

更新日期：2014-05-30 00:00:00

abstract：:Zero-inflated Poisson regression is a popular tool used to analyze data with excessive zeros. Although much work has already been performed to fit zero-inflated data, most models heavily depend on special features of the individual data. To be specific, this means that there is a sizable group of respondents who endor...

journal_title：Statistics in medicine

authors： Lin TH,Tsai MH

更新日期：2013-04-30 00:00:00

abstract：:A new goodness-of-fit test for the logistic regression model is proposed. It exploits the property of this model that when it is correct, i.e. not misspecified, the parameter estimates are (asymptotically) invariant under reweighting the observations by weights wi that are a function of the binary (0/1) outcomes yi. M...

journal_title：Statistics in medicine

authors： Nagelkerke N,Smits J,le Cessie S,van Houwelingen H

更新日期：2005-01-15 00:00:00

abstract：:In an individually matched case-control study, effects of potential risk factors are ascertained through conditional logistic regression (CLR). Extension of CLR to situations with multiple disease or reference categories has been made through polychotomous CLR and is shown to be more efficient than carrying out separa...

journal_title：Statistics in medicine

authors： Mukherjee B,Liu I,Sinha S

更新日期：2007-07-30 00:00:00

abstract：:Suppose that two graders classify all eyes in a sample of patients for the presence or absence of a specified abnormality. In the statistical analysis of the data, possible correlation between the observations in the right and left eyes should be taken into account. Recently, general methods have been developed to ana...

journal_title：Statistics in medicine

authors： Schouten HJ

更新日期：1993-12-15 00:00:00

abstract：:Prognostic models are used in medicine for investigating patient outcome in relation to patient and disease characteristics. Such models do not always work well in practice, so it is widely recommended that they need to be validated. The idea of validating a prognostic model is generally taken to mean establishing tha...

journal_title：Statistics in medicine

authors： Altman DG,Royston P

更新日期：2000-02-29 00:00:00

abstract：:We consider methods for selecting the joint specification of the mean and variance functions in statistical models for rates or counts. Based on analyses of diagnosis-specific hospital discharge rates in Michigan, we show that a Poisson model with an extra variance component for the systematic variation is superior to...

journal_title：Statistics in medicine

authors： Wolfe RA,Petroni GR,McLaughlin CG,McMahon LF Jr

更新日期：1991-09-01 00:00:00

abstract：:The use of both sequential designs and adaptive treatment allocation are effective in reducing the number of patients receiving an inferior treatment in a clinical trial. In large samples, when the asymptotic normality of test statistics can be utilized, a standard sequential design can be combined with adaptive alloc...

journal_title：Statistics in medicine

authors： Stallard N,Rosenberger WF

更新日期：2002-02-28 00:00:00

abstract：:Many reactions in enzymology are governed by the Michaelis-Menten equation. Characterising these reactions requires the estimation of the parameters K(M) and V(max) which determine the Michaelis-Menten equation and this is done by observing rates of reactions at a set of substrate concentrations. The choice of substra...

journal_title：Statistics in medicine

authors： Matthews JN,Allcock GC

更新日期：2004-02-15 00:00:00

abstract：:In genetic association studies, it is typically thought that genetic variants and environmental variables jointly will explain more of the inheritance of a phenotype than either of these two components separately. Traditional methods to identify gene-environment interactions typically consider only one measured enviro...

journal_title：Statistics in medicine

authors： Pashova H,LeBlanc M,Kooperberg C

更新日期：2013-01-30 00:00:00

abstract：:The sojourn time, time spent in the preclinical detectable phase (PCDP) for chronic diseases, for example, breast cancer, plays an important role in the design and assessment of screening programmes. Traditional methods to estimate it usually assume a uniform incidence rate of preclinical disease from a randomized con...

journal_title：Statistics in medicine

authors： Duffy SW,Chen HH,Tabar L,Day NE

更新日期：1995-07-30 00:00:00

abstract：BACKGROUND:The need to deliver interventions targeting multiple diseases in a cost-effective manner calls for integrated disease control efforts. Consequently, maps are required that show where the risk of co-infection is particularly high. Co-infection risk is preferably estimated via Bayesian geostatistical multinomi...

journal_title：Statistics in medicine

authors： Schur N,Gosoniu L,Raso G,Utzinger J,Vounatsou P

更新日期：2011-06-30 00:00:00

abstract：:A good measure of field vaccine efficacy should evaluate the direct protective effect of vaccination on the person who receives the vaccine. The conventional estimator for vaccine efficacy depends on population level factors that are either unrelated or indirectly related to the direct biological action of the vaccine...

journal_title：Statistics in medicine

authors： Longini IM Jr,Halloran ME,Haber M,Chen RT

更新日期：1993-02-01 00:00:00

abstract：:Multilevel and longitudinal studies are frequently subject to missing data. For example, biomarker studies for oral cancer may involve multiple assays for each participant. Assays may fail, resulting in missing data values that can be assumed to be missing completely at random. Catellier and Muller proposed a data ana...

journal_title：Statistics in medicine

authors： Ringham BM,Kreidler SM,Muller KE,Glueck DH

更新日期：2016-07-30 00:00:00

abstract：:Maps of estimated disease rates over multiple time periods are useful tools for gaining etiologic insights regarding potential exposures associated with specific locations and times. In this paper, we describe an extension of the Gangnon-Clayton model for spatial clustering to spatio-temporal data. As in the purely sp...

journal_title：Statistics in medicine

authors： Gangnon RE

更新日期：2010-09-30 00:00:00

abstract：:Identification of key factors associated with the risk of developing cardiovascular disease and quantification of this risk using multivariable prediction algorithms are among the major advances made in preventive cardiology and cardiovascular epidemiology in the 20th century. The ongoing discovery of new risk markers...

journal_title：Statistics in medicine

authors： Pencina MJ,D'Agostino RB Sr,D'Agostino RB Jr,Vasan RS

更新日期：2008-01-30 00:00:00

abstract：:There are many settings in which the distribution of error in a mismeasured covariate varies with the value of another covariate. Take, for example, the case of HIV phylogenetic cluster size, large values of which are an indication of rapid HIV transmission. Researchers wish to find behavioral correlates of HIV phylog...

journal_title：Statistics in medicine

authors： Parveen N,Moodie E,Brenner B

更新日期：2017-07-30 00:00:00

abstract：:To study the spread of sexually transmitted diseases (STDs) using social/sexual mixing models, one must have quantitative information about sexual mixing. An unavoidable complication in gathering such information by survey is that members of the surveyed population will almost certainly have sexual contacts outside th...

journal_title：Statistics in medicine

authors： Rubin G,Umbach D,Shyu SF,Castillo-Chavez C

更新日期：1992-09-15 00:00:00

abstract：:During phase III clinical trials in life-threatening disease settings, it is important to ensure that the Data Monitoring Committee (DMC) has exclusive access to the interim efficacy and safety data generated by the data analysis centre, in order to minimize the risk of widespread prejudgement of unreliable trial resu...

journal_title：Statistics in medicine

authors： Fleming TR,Ellenberg S,DeMets DL

更新日期：2002-10-15 00:00:00

abstract：:Adaptive designs have been proposed for clinical trials in which the nuisance parameters or alternative of interest are unknown or likely to be misspecified before the trial. Although most previous works on adaptive designs and mid-course sample size re-estimation have focused on two-stage or group-sequential designs ...

journal_title：Statistics in medicine

authors： Bartroff J,Lai TL

更新日期：2008-05-10 00:00:00