Boosting for detection of gene-environment interactions.

abstract：:New combination regimens evaluated in phase II cancer clinical trials often show promising results compared to the standard therapy for a disease system. Selection of patients with a better prognosis can be a prominent factor for this optimism. For most disease systems, prognostic variables that are related to the out...

journal_title：Statistics in medicine

authors： Mazumdar M,Fazzari M,Panageas KS

更新日期：2001-03-30 00:00:00

abstract：:Subjective judgements of complex variables are commonly recorded as ordered categorical data. The rank-invariant properties of such data are well known, and there are various statistical approaches to the analysis and modelling of ordinal data. This paper focuses on the non-additive property of ordered categorical dat...

journal_title：Statistics in medicine

authors： Svensson E

更新日期：1998-12-30 00:00:00

abstract：:In Part I we presented a covariance structure model for analysing measurement error in the assessment of nitrogen intake. In this paper we include data on urine nitrogen excretion which allows a critical assessment of the model proposed. Inclusion of urine nitrogen data produces more pessimistic estimates of the quali...

journal_title：Statistics in medicine

authors： Plummer M,Clayton D

更新日期：1993-05-30 00:00:00

abstract：:There is growing interest in how best to adapt and readapt treatments to individuals to maximize clinical benefit. In response, adaptive treatment strategies (ATS), which operationalize adaptive, sequential clinical decision making, have been developed. From a patient's perspective an ATS is a sequence of treatments, ...

journal_title：Statistics in medicine

authors： Almirall D,Compton SN,Gunlicks-Stoessel M,Duan N,Murphy SA

更新日期：2012-07-30 00:00:00

abstract：:For clinical trials with multiple treatment arms or endpoints a variety of sequentially rejective, weighted Bonferroni-type tests have been proposed, such as gatekeeping procedures, fixed sequence tests, and fallback procedures. They allow to map the difference in importance as well as the relationship between the var...

journal_title：Statistics in medicine

authors： Bretz F,Maurer W,Brannath W,Posch M

更新日期：2009-02-15 00:00:00

abstract：:In a recent Statistics in Medicine paper, Warn, Thompson and Spiegelhalter (WTS) made a comparison between the Bayesian approach to the meta-analysis of binary outcomes and a popular Classical approach that uses summary (two-stage) techniques. They included approximate summary (two-stage) Bayesian techniques in their ...

journal_title：Statistics in medicine

authors： O'Rourke K,Altman DG

更新日期：2005-09-15 00:00:00

abstract：:A general method is presented that allows the researcher to change statistical design elements such as the residual sample size during the course of an experiment, to include an interim analysis for early stopping when no formal rule for early stopping was foreseen, to increase or reduce the number of planned interim ...

journal_title：Statistics in medicine

authors： Müller HH,Schäfer H

更新日期：2004-08-30 00:00:00

abstract：:Health surveillance involves collecting public health data on chronic and infectious diseases to detect changes in disease incidence rates in order to improve public health. Timely detection of disease clusters is essential in prospective public health surveillance. Most existing health surveillance research is based ...

journal_title：Statistics in medicine

authors： Jiang W,Han SW,Tsui KL,Woodall WH

更新日期：2011-02-28 00:00:00

abstract：:The one-step (Peto) method for obtaining pooled effect estimates can yield extremely biased results when applied to unbalanced data. Even for balanced studies, the one-step estimate may incorporate an unacceptable degree of bias. In place of the one-step estimate, we recommend use of ordinary Mantel-Haenszel, weighted...

journal_title：Statistics in medicine

authors： Greenland S,Salvan A

更新日期：1990-03-01 00:00:00

abstract：:Age-period-cohort (APC) analysis is widely used in cancer epidemiology to model trends in cancer rates. We develop methods for comparative APC analysis of two independent cause-specific hazard rates assuming that an APC model holds for each one. We construct linear hypothesis tests to determine whether the two hazards...

journal_title：Statistics in medicine

authors： Rosenberg PS,Anderson WF

更新日期：2010-05-20 00:00:00

abstract：:Propensity score analysis is widely used in observational studies to adjust for confounding and estimate the causal effect of a treatment on the outcome. When the outcome is survival time, there are special considerations on the definition of the causal estimand, point, and variance estimation that have not been thoro...

journal_title：Statistics in medicine

authors： Mao H,Li L,Yang W,Shen Y

更新日期：2018-11-20 00:00:00

abstract：:The construction, validation and updating of a prognostic model for kidney graft survival is reported using data from the Eurotransplant database. First, a model is constructed for data from transplantations in the period 1984 to 1987. The model is later updated for the 1988 1990 data. The first data set was randomly ...

journal_title：Statistics in medicine

authors： Van Houwelingen HC,Thorogood J

更新日期：1995-09-30 00:00:00

abstract：:In this paper the following problem of clinical research is explored. Several potential new treatments are available for use against a certain disease. These are evaluated in a series of pilot studies which will constitute phase II clinical trials. The most promising will then be compared with a standard treatment in ...

journal_title：Statistics in medicine

authors： Whitehead J

更新日期：1986-09-01 00:00:00

abstract：:We study the group bridge and the adaptive group bridge penalties for competing risks quantile regression with group variables. While the group bridge consistently identifies nonzero group variables, the adaptive group bridge consistently selects variables not only at group level but also at within-group level. We all...

journal_title：Statistics in medicine

authors： Ahn KW,Kim S

更新日期：2018-04-30 00:00:00

abstract：:We propose a semiparametric method for estimating ROC surfaces for continuous diagnostic tests based on two test measurements. Such a three-class diagnostic problem based on two test measurements arises naturally from some DNA amplification-related diagnostic scenarios. Simulation results show that our proposed semipa...

journal_title：Statistics in medicine

authors： Wan S,Zhang B

更新日期：2009-08-15 00:00:00

abstract：:Most phase I dose-finding methods in oncology aim to find the maximum-tolerated dose from a set of prespecified doses. However, in practice, because of a lack of understanding of the true dose-toxicity relationship, it is likely that none of these prespecified doses are equal or reasonably close to the true maximum-to...

journal_title：Statistics in medicine

authors： Chu Y,Pan H,Yuan Y

更新日期：2016-09-10 00:00:00

abstract：:We survey models for analysing repeated observations on an ordered categorical response variable. The models presented are univariate models that permit correlation among repeated measurements. The models describe simultaneously the dependence of marginal response distributions on values of explanatory variables and o...

journal_title：Statistics in medicine

authors： Agresti A

更新日期：1989-10-01 00:00:00

abstract：:Korn and Whittemore have presented methods for analyzing longitudinal data where the number of observations per individual is large relative to the number of variables considered for each subject. However, this is often not the case in epidemiologic studies, since one usually collects data at relatively few time point...

journal_title：Statistics in medicine

authors： Rosner B,Muñoz A,Tager I,Speizer F,Weiss S

更新日期：1985-10-01 00:00:00

abstract：:Flexible survival models are in need when modelling data from long term follow-up studies. In many cases, the assumption of proportionality imposed by a Cox model will not be valid. Instead, a model that can identify time varying effects of fixed covariates can be used. Although there are several approaches that deal ...

journal_title：Statistics in medicine

authors： Perperoglou A

更新日期：2016-12-10 00:00:00

abstract：:Longitudinal biomarker data are often collected in studies, providing important information regarding the probability of an outcome of interest occurring at a future time. With many new and evolving technologies for biomarker discovery, the number of biomarker measurements available for analysis of disease progression...

journal_title：Statistics in medicine

authors： Zhao L,Murray S,Mariani LH,Ju W

更新日期：2020-11-20 00:00:00

abstract：:In standard time-to-event or survival analysis, occurrence times of the event of interest are observed exactly or are right-censored, meaning that it is only known that the event occurred after the last observation time. There are numerous methods available for estimating the survival curve and for testing and estimat...

journal_title：Statistics in medicine

authors： Lindsey JC,Ryan LM

更新日期：1998-01-30 00:00:00

abstract：:A new exponentially weighted moving average (EWMA) control chart well suited for 'online' routine surveillance of medical procedures is introduced. The chart is based on inter-event counts for failures recorded when the failures occur. The method can be used for many types of hospital procedures and activities, such a...

journal_title：Statistics in medicine

authors： Spliid H

更新日期：2007-01-15 00:00:00

abstract：:When estimating the probability of natural conception from observational data on couples with an unfulfilled child wish, the start of assisted reproductive therapy (ART) is a competing event that cannot be assumed to be independent of natural conception. In clinical practice, interest lies in the probability of natura...

journal_title：Statistics in medicine

authors： van Geloven N,Geskus RB,Mol BW,Zwinderman AH

更新日期：2014-11-20 00:00:00

abstract：:Conditional power based on summary statistic by comparing outcomes (such as the sample mean) directly between 2 groups is a convenient tool for decision making in randomized controlled trial studies. In this paper, we extend the traditional summary statistic-based conditional power with a general model-based assessmen...

journal_title：Statistics in medicine

authors： Zou B,Cai J,Koch GG,Zhou H,Zou F

更新日期：2017-12-30 00:00:00

abstract：:Multistate models are increasingly being used to model complex disease profiles. By modelling transitions between disease states, accounting for competing events at each transition, we can gain a much richer understanding of patient trajectories and how risk factors impact over the entire disease pathway. In this arti...

journal_title：Statistics in medicine

authors： Crowther MJ,Lambert PC

更新日期：2017-12-20 00:00:00

abstract：:We consider the problem of comparing cumulative incidence functions of non-mortality events in the presence of informative coarsening and the competing risk of death. We extend frequentist-based hypothesis tests previously developed for non-informative coarsening and propose a novel Bayesian method based on comparing ...

journal_title：Statistics in medicine

authors： Shardell M,Scharfstein DO,Vlahov D,Galai N

更新日期：2008-12-10 00:00:00

abstract：:This article concerns construction of a confidence surface for tangential slopes of the dose-response surface of a combination therapy to identify where response increases as a function of drug dosage. This approach extends to the assessment of the effectiveness of the combination therapy. ...

journal_title：Statistics in medicine

authors： Hung HM

更新日期：1992-03-01 00:00:00

abstract：:Composite endpoints are frequently used in clinical trials, but simple approaches, such as the time to first event, do not reflect any ordering among the endpoints. However, some endpoints, such as mortality, are worse than others. A variety of procedures have been proposed to reflect the severity of the individual en...

journal_title：Statistics in medicine

authors： Follmann D,Fay MP,Hamasaki T,Evans S

更新日期：2020-02-28 00:00:00

abstract：:In this paper we describe Bonferroni-based multiple testing procedures (MTPs) as strategies to split and recycle test mass. Here, 'test mass' refers to (parts of) the nominal level alpha at which the family-wise error rate is controlled. Briefly, test mass is split between different null hypotheses, and whenever a nul...

journal_title：Statistics in medicine

authors： Burman CF,Sonesson C,Guilbaud O

更新日期：2009-02-28 00:00:00

abstract：:The present study investigates the performance of several statistical tests to detect publication bias in diagnostic meta-analysis by means of simulation. While bivariate models should be used to pool data from primary studies in diagnostic meta-analysis, univariate measures of diagnostic accuracy are preferable for t...

journal_title：Statistics in medicine

authors： Bürkner PC,Doebler P

更新日期：2014-08-15 00:00:00