Optimal designs for Michaelis-Menten kinetic studies.

Abstract:

:Many reactions in enzymology are governed by the Michaelis-Menten equation. Characterising these reactions requires the estimation of the parameters K(M) and V(max) which determine the Michaelis-Menten equation and this is done by observing rates of reactions at a set of substrate concentrations. The choice of substrate concentrations is investigated by determining Bayesian D-optimal designs for a model in which residuals have a normal distribution with constant variance. Designs which focus on alternative quantities, such as K(M) or the ratio V(max)/K(M) are also considered. The effect on the optimal designs of alternative error distributions is also considered.

journal_name

Stat Med

journal_title

Statistics in medicine

authors

Matthews JN,Allcock GC

doi

10.1002/sim.1612

subject

Has Abstract

pub_date

2004-02-15 00:00:00

pages

477-91

issue

3

eissn

0277-6715

issn

1097-0258

journal_volume

23

pub_type

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