Abstract:
:Many reactions in enzymology are governed by the Michaelis-Menten equation. Characterising these reactions requires the estimation of the parameters K(M) and V(max) which determine the Michaelis-Menten equation and this is done by observing rates of reactions at a set of substrate concentrations. The choice of substrate concentrations is investigated by determining Bayesian D-optimal designs for a model in which residuals have a normal distribution with constant variance. Designs which focus on alternative quantities, such as K(M) or the ratio V(max)/K(M) are also considered. The effect on the optimal designs of alternative error distributions is also considered.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Matthews JN,Allcock GCdoi
10.1002/sim.1612subject
Has Abstractpub_date
2004-02-15 00:00:00pages
477-91issue
3eissn
0277-6715issn
1097-0258journal_volume
23pub_type
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