Abstract:
:Many randomized clinical trials include a data and safety monitoring board (DSMB) that is responsible for reviewing accruing data, monitoring performance of the trial, assuring safety of the participants in the trial, and assessing the efficacy of treatment. The DSMB often makes recommendations about continuation of the trial or alteration of the protocol. Although such boards are very influential in both the conduct and interpretation of randomized clinical trials, there is no standard mode in which DSMBs operate nor do they routinely report publicly about their deliberations. This paper describes the composition of DSMBs as well as their functions. It concludes with a series of questions that needs to be addressed to ensure that the DSMBs operate effectively.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Wittes Jdoi
10.1002/sim.4780120504subject
Has Abstractpub_date
1993-03-01 00:00:00pages
419-24issue
5-6eissn
0277-6715issn
1097-0258journal_volume
12pub_type
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