Abstract:
:Issues concerning the past and future development of medicinal herbs from Chinese medicine (CM) are addressed in this paper. In the Western world, medicinal herbs are becoming increasingly popular and important in the public and scientific communities. In contrast to their regulated status in China and other countries, herbal medicines are regarded as dietary supplements in the US. Accordingly, research must continue worldwide to identify and improve the efficacy of the active principals of herbs both singly and in combination -- from active ingredients, active fractions, and active herbal formulations. While Western medicine currently employs pure, single compounds, either natural or synthetic, CM has long used multiple combinations of compounds in the form of processed natural products, primarily medicinal herbs, to treat and relieve the symptoms of many different human diseases. CM may have fewer and less severe side effects than single pure drugs, making CM especially attractive to the consumer. In effect, CM's focus on combination therapy does serve both ancient and modern theories. However, research using modern analytical and chemical techniques is needed to ensure efficacy and safety, to provide qualitative and quantitative analyses for dietary supplements, and to develop new, effective and safe world-class drugs. Drug design is an iterative process. Bioactivity-directed fractionation and isolation identify active natural compounds from single herbs or formulations. These lead structures can be chemically modified and improved through knowledge of structure--activity relationship, mechanism of action, drug metabolism, molecular modelling and combinatorial chemistry studies. Finally, efficacy and toxicity determination as well as clinical trials can contribute to the generation of new drugs from CM. To continue the legacy of CM, as well as the worldwide uses of other medicinal herbs, continued investigation of active formulations, bioactive fractions, and isolated compounds is critical to drug development in the 21st century.
journal_name
Public Health Nutrjournal_title
Public health nutritionauthors
Lee KHdoi
10.1017/s1368980000000604subject
Has Abstractpub_date
2000-12-01 00:00:00pages
515-22issue
4Aeissn
1368-9800issn
1475-2727pii
S1368980000000604journal_volume
3pub_type
杂志文章,评审abstract:OBJECTIVE:To measure folic acid awareness and intake rates among women of childbearing age in certain areas of China with a high prevalence of neural tube defects (NTD). DESIGN:A cross-sectional survey was carried out utilising a nineteen-item questionnaire enquiring into individual women's knowledge of, attitude towa...
journal_title:Public health nutrition
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doi:10.1017/S1368980011000097
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abstract:OBJECTIVE:To evaluate agreement of the body adiposity index (BAI) and paediatric body adiposity index (BAIp) in estimating body fat compared with dual-energy X-ray absorptiometry (DXA) and to propose cut-off points for these indices to classify excess adiposity in Brazilian children and adolescents. DESIGN:Cross-secti...
journal_title:Public health nutrition
pub_type: 杂志文章
doi:10.1017/S1368980018002458
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abstract:OBJECTIVE:To determine if 7 d physical activity (PA) predicts energy intake over the same days and if PA on a given day predicts energy intake on the same day, the next day or subsequent days. DESIGN:A 7 d prospective investigation. PA was measured using accelerometers worn for seven consecutive days. During the same ...
journal_title:Public health nutrition
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doi:10.1017/S1368980016001841
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To assess and compare the favourability of healthy public policy options to promote healthy eating from the perspective of members of the general public and policy influencers in two Canadian provinces. DESIGN:The Chronic Disease Prevention Survey, administered in 2016, required participants to rank their le...
journal_title:Public health nutrition
pub_type: 杂志文章
doi:10.1017/S1368980018004068
更新日期:2019-06-01 00:00:00
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journal_title:Public health nutrition
pub_type: 杂志文章
doi:10.1017/S1368980011001480
更新日期:2012-03-01 00:00:00
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doi:10.1017/S1368980014002997
更新日期:2015-08-01 00:00:00
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doi:10.1017/S136898001900017X
更新日期:2019-07-01 00:00:00
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journal_title:Public health nutrition
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doi:10.1017/S1368980009005308
更新日期:2009-12-01 00:00:00
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更新日期:2020-11-23 00:00:00
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journal_title:Public health nutrition
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doi:10.1017/S1368980015003201
更新日期:2016-07-01 00:00:00
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journal_title:Public health nutrition
pub_type: 杂志文章
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更新日期:2006-09-01 00:00:00
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journal_title:Public health nutrition
pub_type: 杂志文章
doi:10.1079/PHN2003531
更新日期:2004-04-01 00:00:00
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journal_title:Public health nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1017/S1368980019001629
更新日期:2019-10-01 00:00:00
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journal_title:Public health nutrition
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doi:10.1017/S136898001600197X
更新日期:2016-12-01 00:00:00
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journal_title:Public health nutrition
pub_type: 杂志文章,多中心研究
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更新日期:2011-01-01 00:00:00
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journal_title:Public health nutrition
pub_type: 杂志文章
doi:10.1017/S1368980014002419
更新日期:2015-07-01 00:00:00
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journal_title:Public health nutrition
pub_type: 杂志文章
doi:10.1017/S1368980014002602
更新日期:2015-08-01 00:00:00
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journal_title:Public health nutrition
pub_type: 杂志文章
doi:10.1017/S1368980013001602
更新日期:2013-11-01 00:00:00
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journal_title:Public health nutrition
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更新日期:2014-01-01 00:00:00
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journal_title:Public health nutrition
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更新日期:2007-06-01 00:00:00
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更新日期:2008-03-01 00:00:00
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更新日期:2005-08-01 00:00:00
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journal_title:Public health nutrition
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更新日期:2014-04-01 00:00:00
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journal_title:Public health nutrition
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更新日期:2020-12-01 00:00:00
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journal_title:Public health nutrition
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更新日期:2010-02-01 00:00:00
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journal_title:Public health nutrition
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更新日期:2017-10-01 00:00:00
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journal_title:Public health nutrition
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doi:10.1079/PHN2002263
更新日期:2002-04-01 00:00:00
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journal_title:Public health nutrition
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更新日期:2018-09-01 00:00:00
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doi:10.1017/S1368980007000316
更新日期:2008-03-01 00:00:00
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journal_title:Public health nutrition
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doi:10.1079/PHN2002358
更新日期:2002-12-01 00:00:00