Abstract：
:The extraordinarily high rate of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) in the Chamorro linguistic group on Guam suggested a genetic etiology for these diseases. Results of three studies are described. Two involved comparisons of the rates of disease in relatives and spouses of index patients and controls. In the third we examined offspring of doubly affected parents, 10 spouse pairs with ALS, 3 spouse pairs with PD and 13 spouse pairs in which 1 spouse had ALS and the other PD. Within the limitations of numbers and age of offspring, we found a tendency among siblings and offspring of ALS cases to have a higher risk than control relatives. Numbers were small and in no instance were significant differences encountered. Spouses of patients had at least as high risk of developing ALS or PD as any of the groups of blood relatives. A slightly higher age-specific rate of ALS and PD occurred in the offspring of doubly affected parents. The only group large enough for present analysis are 60 offspring of doubly affected ALS parents over the age of 20. Thus far only 3 have developed ALS. Within our entire patient population of 350 ALS cases and 219 PD cases there were 12 instances in which one parent of the patient was not Chamorro. In addition there is a consistent two- to threefold excess of affected males which could not be accounted for by competitive risks of death from other causes among females. While a familial tendency does exist these findings and observations are not compatible with any simple Mendelian form of inheritance. It is possible that genetic influences affect the occurrence of these diseases but our studies suggest that environmental factors play at least as important a role.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Reed DM,Torres JM,Brody JAdoi
10.1093/oxfordjournals.aje.a112098subject
Has Abstractpub_date
1975-04-01 00:00:00pages
302-10issue
4eissn
0002-9262issn
1476-6256journal_volume
101pub_type
杂志文章abstract：:Lower intake of the essential trace element selenium may be a risk factor for prostate cancer and other cancers. In the United States, many racial disparities in cancer incidence, such as the 61% higher incidence of prostate cancer among Blacks relative to Whites, remain unexplained. Using data from a large, nationall...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm075
更新日期：2007-08-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/152.2.132
更新日期：2000-07-15 00:00:00
abstract：:The authors examined the relation between age at first vaginal intercourse and a positive nucleic acid amplification test for sexually transmitted infection (STI). A nationally representative sample of 9,844 respondents aged 18-26 years was tested for chlamydial infection, gonorrhea, and trichomoniasis in wave 3 (2001...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwi095
更新日期：2005-04-15 00:00:00
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pub_type： 评论,杂志文章
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更新日期：2017-02-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：1986-03-01 00:00:00
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doi：10.1093/oxfordjournals.aje.a113963
更新日期：1984-12-01 00:00:00
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更新日期：2012-05-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114040
更新日期：1985-04-01 00:00:00
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更新日期：2013-11-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：1975-03-01 00:00:00
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更新日期：2003-11-15 00:00:00
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更新日期：1989-10-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章,meta分析,评审
doi：10.1093/aje/kwi174
更新日期：2005-07-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwq217
更新日期：2010-10-15 00:00:00
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更新日期：2004-06-15 00:00:00
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116101
更新日期：1991-08-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwp238
更新日期：2009-10-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1093/oxfordjournals.aje.a009975
更新日期：1999-07-15 00:00:00
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更新日期：2012-10-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：1975-09-01 00:00:00
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更新日期：1994-11-15 00:00:00
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更新日期：2007-12-15 00:00:00
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journal_title：American journal of epidemiology
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更新日期：1983-12-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：2006-07-15 00:00:00
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journal_title：American journal of epidemiology
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更新日期：1979-05-01 00:00:00
