Abstract：
:Of the 25,000 new cases of breast cancer annually in the UK, at least half will develop metastases at some time. Approximately one-third of these will be hormone-sensitive and thus suitable for endocrine manipulation. Such patients may live for several years. Care should be patient-centred and evidence-based, with primary care playing an integral part in the multidisciplinary team. Quality of life is paramount, and largely determines decisions to change endocrine therapy. Tamoxifen remains the first choice treatment, but newer agents, in particular the oral aromatase inhibitors, have successfully extended the range of therapy available. Ovarian ablation can be effectively achieved using LHRH analogues, which have the advantage of being reversible if ineffective. In future, further improvements in outcome are likely with new pure antioestrogens and the possibility of sequential or combined use of existing drugs.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Theobald AJsubject
Has Abstractpub_date
2000-12-01 00:00:00pages
665-9issue
10eissn
1368-5031issn
1742-1241journal_volume
54pub_type
杂志文章,评审abstract：:This double-blind, randomised placebo-controlled, multicentre study evaluated the efficacy, tolerability and safety of 12 weeks' treatment with controlled release darifenacin 15 mg once daily (qd), in 445 patients with overactive bladder (OAB). The primary endpoint was warning time (time from first sensation of urgenc...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1368-5031.2005.00770.x
更新日期：2006-01-01 00:00:00
abstract：:Graham Jackson introduced the concept that erectile dysfunction was a marker for undiagnosed cardiovascular disease and future events. Unfortunately this had had modest impact on CVD management as ED is not incorporated into current risk calculators. In this paper, we examine recent evidence as to whether ED should be...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13054
更新日期：2018-02-01 00:00:00
abstract：AIMS:To establish the effectiveness of antidiabetic therapy and the frequency of clinical inertia in the management of type 2 diabetes mellitus in Colombia. METHODS:A cross-sectional study with follow-up of patients who had been treated for at least 1 year and were receiving medical consultation for antidiabetic treat...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12954
更新日期：2017-06-01 00:00:00
abstract：AIMS:To validate a previously developed set of explicit criteria for the appropriateness of hospital admission among these patients using the RAND/UCLA Appropriateness Methodology (RAM). METHODS:We conducted a prospective cohort study of patients experiencing symptoms of COPD exacerbation seen in the emergency departm...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12397
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:We aimed to evaluate the effect of body mass index (BMI) on oncological and surgical outcomes in patients who underwent radical cystectomy (RC) for bladder cancer (BC). MATERIALS AND METHODS:We retrospectively assessed data from patients who underwent RC with pelvic lymphadenectomy and urinary diversion for ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13750
更新日期：2020-10-08 00:00:00
abstract：AIM:Osteoporosis and sarcopenia are common health problems in postmenopausal women. However, studies of these issues in premenopausal women are limited. Our present study aimed to investigate relationship the between underweight, bone mineral density (BMD) and skeletal muscle index (SMI) in a representative sample of p...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12801
更新日期：2016-06-01 00:00:00
abstract：:Cystic fibrosis (CF) is one of the commonest lethal inherited conditions among Caucasians. It affects multiple organ systems and exhibits a range of clinical problems of varying severity. Life expectancy has improved in recent years as treatment regimes have become more intensive, but current treatments are expensive,...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Upper gastrointestinal (UGI) haemorrhage is a frequent cause of hospital admission. Scoring systems have been devised to identify those at risk of adverse outcomes. We evaluated the Glasgow Blatchford score's (GBS) ability to identify the need for clinical and endoscopic intervention in patients with UGI hae...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2009.02267.x
更新日期：2010-06-01 00:00:00
abstract：:A 43-year-old female patient with Basedow-Graves' disease developed agranulocytosis in the eighth month of propylthiouracil therapy. After discontinuing the drug, a broad spectrum antibiotic regimen plus recombinant human granulocyte colony-stimulating factor (G-CSF), a human haematopoietic growth factor, were started...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：:Objectives: The purpose of this updated meta-analysis was to determine whether exercise training reversed left ventricular remodelling in heart failure patients. Methods: Articles were searched in MEDLINE, Cochrane Central Register of Controlled Trials, CINAHL, EMBASE and PubMed (up until October, 2011). The anti-re...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2012.02942.x
更新日期：2012-08-01 00:00:00
abstract：:In 2006 Meiron Thomas, writing in the British Journal of Surgery, made the following statement about the value of sentinel lymph node biopsy (SLNB) as a staging procedure in cutaneous malignant melanoma (1): "Perhaps a more important concern for those hoping to gain reassurance from accurate nodal staging relates to p...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2011.02829.x
更新日期：2012-07-01 00:00:00
abstract：:This double-blind, randomised, controlled study compared the efficacy of candesartan cilexetil 8 mg (n = 87) and losartan 50 mg (n = 89), once daily for 6 weeks, relative to placebo (n = 80) in patients with mild-to-moderate essential hypertension (diastolic blood pressure (DBP): 95-115 mmHg). Ambulatory BP measuremen...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1368-5031.2006.00903.x
更新日期：2006-04-01 00:00:00
abstract：:Primary palmar hyperhidrosis is a disabling disorder that starts in childhood and causes physical and psychological inconvenience. Conservative treatment is not effective in severe cases. Thoracoscopic sympathectomy is the treatment of choice. It is a safe minimally invasive procedure with good results. There are few ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:There has been a dramatic increase in the incidence of immediate breast reconstruction after mastectomy for breast cancer over the past few decades and autologous tissue flaps are being used with increasing frequency. Concern has been expressed that these complex procedures may lead to a delay in the deliver...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2009.02199.x
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Stroke risk is heightened among patients who have had a primary stroke or transient ischaemic attack (TIA). The primary care physician is in the best position to monitor these patients for stroke recurrence. Because stroke recurrence can occur shortly after the primary event, guidelines recommend initiating ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2007.01515.x
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Mobile smart phones have become increasingly integrated into the practice of doctors and allied medical professionals. Recent studies suggest them to represent reservoirs for pathogens with potential to cause nosocomial infections. This study aimed to investigate the level of contamination on phones used on ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12448
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Exhaustion is the perception of low energy. Little is known about how exhaustion persists, remits or reappears over time in patients with chronic obstructive pulmonary disease (COPD) or how to predict these events. We determined the likelihood of transitions between states of exhaustion and no ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13068
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:People with depressive disorders or subsyndromal symptoms of depression (SSD) often use complementary and alternative therapies, including massage therapy (MT). This systematic review evaluates the evidence, from randomised clinical trials (RCTs), for the effectiveness of multiple sessions of classical Europ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2007.01553.x
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Ageing is intrinsically associated with a progressive decline in cardiorespiratory fitness (CRF) as measured by peak oxygen uptake (VO2peak ). Improving CRF through physical activity contribute to better and healthy ageing. High-intensity interval training (HIIT) is a potent method of improving CRF among sen...
journal_title：International journal of clinical practice
pub_type： 杂志文章,meta分析
doi：10.1111/ijcp.13490
更新日期：2020-06-01 00:00:00
abstract：INTRODUCTION:Niacin is underutilised because of flushing. Lack of a quantitative tool to assess niacin-induced flushing has precluded the objective evaluation of flushing associated with extended-release (ER) niacin formulations. We developed the Flushing Symptom Questionnaire((c)) (FSQ), a quantitative tool to assess ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1742-1241.2008.01739.x
更新日期：2008-06-01 00:00:00
abstract：:Fluid in the pleural space is a common sequela of a wide range of diseases which may be pulmonary, pleural or extrapulmonary. As the differential diagnosis is wide, a systematic approach to investigation and diagnosis is recommended. This review highlights the important features and recommendations for the investigati...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2009.02068.x
更新日期：2009-11-01 00:00:00
abstract：:Lansoprazole is a proton pump inhibitor that reduces gastric acid secretion in a dose-dependent manner via inhibition of H+/K+-adenosine triphosphatase in gastric parietal cells. It also exhibits antibacterial activity against Helicobacter pylori in vitro. During almost 10 years of clinical use, lansoprazole has prove...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:In 2006, the American Diabetes Association and the European Association for the Study of Diabetes established a consensus algorithm (ADA/EASD-2006) for the adjustment of drug therapy for type 2 diabetes mellitus (T2DM). AIMS:To study glycaemic control in T2DM patients and the implementation of the ADA/EASD-...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1111/ijcp.12251
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To determine the efficacy and safety of linagliptin in initial combination with metformin in patients with type 2 diabetes. METHODS:This 1-year randomised, double-blind study was an extension of a 6-month randomised controlled trial, in which adults with type 2 diabetes received one of six treatment regimens...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/ijcp.12308
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Limited research has examined the fat-but-fit paradigm among coronary artery disease patients. OBJECTIVES:The objective of this study was to evaluate the fat-but-fit paradigm as it relates to mortality risk among patients with coronary artery disease. METHODS:A total of 766 coronary artery disease patients...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12799
更新日期：2016-05-01 00:00:00
abstract：:Some chiropractors claim that spinal manipulation is an effective treatment for infant colic. This systematic review was aimed at evaluating the evidence for this claim. Four databases were searched and three randomised clinical trials met all the inclusion criteria. The totality of this evidence fails to demonstrate ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2009.02133.x
更新日期：2009-09-01 00:00:00
abstract：:Despite concerns in the 1970s and 1980s about the safety of short-acting beta2-agonists, it is now generally accepted that these agents, used at appropriate doses, provide safe and effective treatment for asthma symptoms. After their introduction, beta2-agonists with a long duration of action--formoterol and salmetero...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：
更新日期：2003-10-01 00:00:00
abstract：:Leptospirosis is a re-emerging spirochetal zoonosis with a worldwide distribution affecting both animals and humans. The clinical syndromes may vary from a subclinical infection to a severe illness. Although it may potentially have a fulminant and fatal course, leptospirosis usually remains as an underdiagnosed cause ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2005.00638.x
更新日期：2007-01-01 00:00:00
abstract：:Despite huge advances in terms of the impact of antiretroviral therapy on HIV-related morbidity and mortality patients continue to fail therapy. We discuss the reasons why failure occurs including primary or transmitted resistance, poor adherence, toxicity and drug potency. We performed a review of PubMed, Medline and...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2007.01383.x
更新日期：2007-06-01 00:00:00
abstract：:The aim of this study was to review the application of antimicrobial stewardship principles to the management of community-acquired pneumonia (CAP). Data from 14 published clinical studies, meta-analyses and practice guidelines regarding the application of antimicrobial stewardship strategies to the management of CAP ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2011.02704.x
更新日期：2011-07-01 00:00:00
