Abstract:
:As the exponential growth of DNA sequence information in databases continues, the task of converting this deposited information into knowledge becomes more dependent on integrative sequence analysis and visualization tools. PANORAMA is an Internet-accessible software package that performs a variety of informatics analyses on a given DNA sequence and returns a visual and interactive representation of the results. Its design is modular, so that further sequence analysis tools can be integrated with minimal effort. The utility of PANORAMA is demonstrated in the analysis of 650 kb of human genomic DNA from chromosome region 3p21.3, a region of potential tumor suppressor genes involved in lung cancer, breast cancer, and other forms of cancer. PANORAMA aided in the discovery of genes and alternate splice forms of known exons, in the demarcation of intron-exon boundaries, and in the identification of promoter regions and polymorphisms, all of which contributed to a better understanding of the region. PANORAMA is available on the World Wide Web at http://atlas.swmed.edu.
journal_name
Genomicsjournal_title
Genomicsauthors
Pertsemlidis A,Pande A,Miller B,Schilling P,Wei MH,Lerman MI,Minna JD,Garner HR,Mittelman Ddoi
10.1006/geno.2000.6359subject
Has Abstractpub_date
2000-12-15 00:00:00pages
300-6issue
3eissn
0888-7543issn
1089-8646pii
S0888754300963596journal_volume
70pub_type
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