Insulin-mediated cellular insulin resistance decreases osmotic shock-induced glucose transport in 3T3-L1 adipocytes.

abstract：:Desensitization and internalization of G protein-coupled receptors can be mediated by phosphorylation within the C-terminal tail, facilitating beta-arrestin binding and targeting the receptor for internalization. Type II GnRH receptors (GnRH-Rs) show such regulation, but type I GnRH-Rs lack C-tails and are not rapidly...

journal_title：Endocrinology

authors： Caunt CJ,Hislop JN,Kelly E,Matharu AL,Green LD,Sedgley KR,Finch AR,McArdle CA

更新日期：2004-08-01 00:00:00

abstract：:There is considerable evidence that CRH can suppress food intake. As hypothalamic CRH, a main site of CRH expression, is also negatively regulated by glucocorticoids, it is unclear whether anorexia and weight loss in adrenal insufficiency are attributable to elevated CRH or to decreased glucocorticoid levels. To disti...

journal_title：Endocrinology

authors： Jacobson L

更新日期：1999-01-01 00:00:00

abstract：:The secretion of LH, PRL, and cortisol was investigated in 4 sexually mature female rhesus macaques with cardiac catheters protected by tethers. Based on endocrine parameters, all 4 of the animals ovulated within 2 months from the time they were tethered, and regular menstrual cycles of 24-34 days were observed. The c...

journal_title：Endocrinology

authors： Norman RL,Lindstrom SA,Bangsberg D,Ellinwood WE,Gliessman P,Spies HG

更新日期：1984-07-01 00:00:00

abstract：:Aldo-keto-reductase 1B7/mouse vas deferens protein (AKR1B7/MVDP) is expressed in rodent steroidogenic glands and in the mouse vas deferens. In steroidogenic organs, AKR1B7/MVDP scavenges isocaproaldehyde produced from the cholesterol side-chain cleavage reaction. Akr1b7/mvdp is responsive to ACTH in adrenals and to an...

journal_title：Endocrinology

authors： Martinez A,Val P,Sahut-Barnola I,Aigueperse C,Veyssière G,Lefrançois-Martinez AM

更新日期：2003-05-01 00:00:00

abstract：:We have examined expression of the chicken PRL receptor (cPRLR) gene in different tissues of the chicken by Northern blot analysis. Most tissues examined (ovary, testis, oviduct, kidney, and fat) possess a prominent full-length (4.6-kb) cPRLR transcript. A larger (11.7-kb) transcript is also detected in ovary, oviduct...

journal_title：Endocrinology

authors： Mao JN,Burnside J,Li L,Tang J,Davolos C,Cogburn LA

更新日期：1999-03-01 00:00:00

abstract：:Five studies are reported which were designed to define the effects of an estrogen and a progestogen, alone and in combination, on tissue concentrations (heart, kidney, and liver) of two trace metals (zinc, copper) and four bulk cations (sodium, potassium, calcium, magnesium). Male rats received Premarin (0.08 mg) and...

journal_title：Endocrinology

authors： Yunice AA,Lindeman RD

更新日期：1975-11-01 00:00:00

abstract：:Endocrine cells isolated from the anterior pituitary fire intracellular Ca2+ ([Ca2+]i) transients due to voltage-gated Ca2+ entry. However, the patterns of [Ca2+]i transients within the glandular parenchyma of the anterior pituitary are unknown. Here we describe, using real-time confocal laser microscopy, several spon...

journal_title：Endocrinology

authors： Bonnefont X,Fiekers J,Creff A,Mollard P

更新日期：2000-03-01 00:00:00

abstract：:We hypothesized the existence of vagal arginine sensors in the liver which modulate arginine-induced pancreatic hormone secretion. The present study was carried out to examine the efferent pathways and receptor mechanisms from arginine sensors using selective vagotomies and autonomic drugs on the secretion of insulin ...

journal_title：Endocrinology

authors： Tanaka K,Inoue S,Nagase H,Takamura Y

更新日期：1990-10-01 00:00:00

abstract：:Some 17 alpha-alkylated androgens used as anabolic agents, such as stanozolol (ST) and danazol (DA), have specific effects on the liver that are not exerted by testosterone. This gives rise to the possibility that a steroid-binding protein, other than the androgen receptor, could modulate the intracellular actions of ...

journal_title：Endocrinology

authors： Fernández L,Chirino R,Boada LD,Navarro D,Cabrera N,del Rio I,Díaz-Chico BN

更新日期：1994-03-01 00:00:00

abstract：:IGF binding protein-3 (IGFBP-3), the most abundant circulating IGF binding protein, inhibits cell growth and induces apoptosis by both IGF-I-dependent and -independent pathways. The ability of IGFBP-3 to inhibit tumor growth has been demonstrated in many cancers including prostate cancer (PCa). High concentrations of ...

journal_title：Endocrinology

authors： Peng L,Malloy PJ,Wang J,Feldman D

更新日期：2006-10-01 00:00:00

abstract：:After reproductive senescence or gonadectomy, changes occur in neural gene expression, ultimately altering brain function. The endocrine mechanisms underlying these changes in gene expression beyond immediate hormone loss are poorly understood. To investigate this, we measured changes in gene expression the dorsal str...

journal_title：Endocrinology

authors： Meitzen J,Perry AN,Westenbroek C,Hedges VL,Becker JB,Mermelstein PG

更新日期：2013-05-01 00:00:00

abstract：:Functional disruption of either MC3R or MC4R results in obesity, implicating both in the control of energy homeostasis. The ligands for these receptors are derived from the prohormone proopiomelancortin (POMC), which is posttranslationally processed to produce a set of melanocortin peptides with a range of activities ...

journal_title：Endocrinology

authors： Tung YC,Piper SJ,Yeung D,O'Rahilly S,Coll AP

更新日期：2006-12-01 00:00:00

abstract：:GH promotes not only longitudinal growth in children but is active throughout life in protein, fat, and carbohydrate metabolism. The multiple actions of GH start when GH binds to the cell surface-expressed GH receptor. Effectiveness of the hormone depends both on its presence in the circulation and the availability of...

journal_title：Endocrinology

authors： van Kerkhof P,Smeets M,Strous GJ

更新日期：2002-04-01 00:00:00

abstract：:Although atrial and brain natriuretic peptides are well known to be involved in the regulation of cardiovascular and endocrine functions as circulating hormones, the roles of the C-type natriuretic peptide (CNP) remain unknown. We examined the effects of CNP on the secretion of aldosterone and cyclic nucleotides from ...

journal_title：Endocrinology

authors： Kawai M,Naruse M,Yoshimoto T,Naruse K,Shionoya K,Tanaka M,Morishita Y,Matsuda Y,Demura R,Demura H

更新日期：1996-01-01 00:00:00

abstract：:Previously, we demonstrated that excision of the GnRH first intron (intron A) was largely attenuated in non-GnRH-producing tissues but accelerated in GnRH neurons. In the present study, we examined the splicing rate of GnRH pre-mRNA in developing normal mice and adult hypogonadal mice. The preoptic area and cerebral c...

journal_title：Endocrinology

authors： Seong JY,Kim BW,Park S,Son GH,Kim K

更新日期：2001-10-01 00:00:00

abstract：:Melanocortin receptor 4 (MCR4) and CB(1) cannabinoid receptors independently modulate food intake. Although an interaction between the cannabinoid and melanocortin systems has been found in recovery from hemorrhagic shock, the interaction between these systems in modulating food intake has not yet been examined. The p...

journal_title：Endocrinology

authors： Verty AN,McFarlane JR,McGregor IS,Mallet PE

更新日期：2004-07-01 00:00:00

abstract：:In vivo studies have suggested that serotonin (5HT) influences anterior pituitary function at the hypothalamic level. The present in vitro study investigated the possibility that 5HT may act directly on the anterior pituitary. The high affinity uptake of [3H]5HT into adult rat anterior pituitary tissue was examined in...

journal_title：Endocrinology

authors： Johns MA,Azmitia EC,Krieger DT

更新日期：1982-03-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is more severe in male than female mice eating a soy-based diet. We sought to determine whether the detrimental effects are mediated by the phytoestrogens present in soy, the mechanism by which phytoestrogens act, and to test whether estrogen modulates the sexually dimorphic phenotype...

journal_title：Endocrinology

authors： Haines CD,Harvey PA,Luczak ED,Barthel KK,Konhilas JP,Watson PA,Stauffer BL,Leinwand LA

更新日期：2012-09-01 00:00:00

abstract：:The adrenal gland is highly vascularized with tightly regulated blood flow that is closely correlated with steroidogenesis. Mechanisms involved in the regulation of adrenal blood flow and vascular tone are largely unknown. The present study characterizes the contractile responses of isolated small cortical arteries fr...

journal_title：Endocrinology

authors： Zhang DX,Gauthier KM,Campbell WB

更新日期：2004-04-01 00:00:00

abstract：:Prostaglandin (PG) E2 (PGE(2)) plays a central role in the regulation of smooth muscle contractions. Classically, PGE(2) stimulates contractions via EP1 and EP3 receptors, whereas EP2 and EP4 maintain quiescence. Labor involves a change from myometrial quiescence to contractions with a shift from anti- to proinflammat...

journal_title：Endocrinology

authors： Kandola MK,Sykes L,Lee YS,Johnson MR,Hanyaloglu AC,Bennett PR

更新日期：2014-02-01 00:00:00

abstract：:Groups of female ferrets born in the laboratory received sc Silastic capsules containing testosterone (T), 5 alpha-dihydrotestosterone (DHT), 17 beta-estradiol (E), or no steroid for 15 days beginning on the day of birth; an additional group of male ferrets received empty sc capsules neonatally. All ferrets were gonad...

journal_title：Endocrinology

authors： Baum MJ,Gallagher CA,Martin JT,Damassa DA

更新日期：1982-09-01 00:00:00

abstract：:Recent evidence has linked mitochondrial dysfunction and DNA damage, increased oxidative stress in skeletal muscle, and insulin resistance (IR). The purpose of this study was to determine the role of the DNA repair enzyme, human 8-oxoguanine DNA glycosylase/apurinic/apyrimidinic lyase (hOGG1), on palmitate-induced mit...

journal_title：Endocrinology

authors： Yuzefovych LV,Schuler AM,Chen J,Alvarez DF,Eide L,Ledoux SP,Wilson GL,Rachek LI

更新日期：2013-08-01 00:00:00

abstract：:Serum LH and FSH were measured at 60, 30, and 0 min before, at 5, 15, and 30 min during, and at 10, 45, and 90 min after bilateral electrical stimulation (ES) of various hypothalamic regions in 12 unanesthetized ovariectomized rhesus monkeys. ES of the arcuate-ventromedial nuclei (medial basal hypothalamus; MBH) induc...

journal_title：Endocrinology

authors： Spies HG,Norman RL,Quadri SK,Clifton DK

更新日期：1977-02-01 00:00:00

abstract：:The physiology and regulation of steroid synthesis in the brain have emerged as important for understanding brain function. Neurosteroids, those steroids synthesized de novo in nervous tissue, have been associated with numerous central nervous system functions, including myelination, mental retardation, and epilepsy. ...

journal_title：Endocrinology

authors： Micevych P,Sinchak K

更新日期：2008-06-01 00:00:00

abstract：:To elucidate the mechanism of humoral hypercalcemia elicited by human esophageal carcinoma cells (EC-GI), which constitutively produced interleukin-1 alpha (IL-1 alpha) and PTH-like factor, the effects of IL-1 alpha and PTH-related protein (PTH-rP) on bone resorption in vitro and on serum calcium concentrations in viv...

journal_title：Endocrinology

authors： Sato K,Fujii Y,Kasono K,Ozawa M,Imamura H,Kanaji Y,Kurosawa H,Tsushima T,Shizume K

更新日期：1989-05-01 00:00:00

abstract：:A monoclonal antibody directed against bovine TSH was obtained by hybridoma technology. This antibody was specific for TSH and did not react with bovine LH and FSH. Affinity chromatography of crude TSH was performed on anti-TSH Sepharose. Bovine TSH was purified in a single step to near homogeneity by this technique, ...

journal_title：Endocrinology

authors： Lock AJ,van Denderen J,Aarden LA

更新日期：1988-01-01 00:00:00

abstract：:PTH-related protein (PTHrP) and its receptor are expressed in vascular smooth muscle cells and are believed to participate in the local regulation of vascular tone. To explore the function of locally produced PTHrP in vascular smooth muscle in vivo, we developed transgenic mice that overexpress PTHrP in smooth muscle ...

journal_title：Endocrinology

authors： Maeda S,Sutliff RL,Qian J,Lorenz JN,Wang J,Tang H,Nakayama T,Weber C,Witte D,Strauch AR,Paul RJ,Fagin JA,Clemens TL

更新日期：1999-04-01 00:00:00

abstract：:Although LHRH can stimulate the release of both LH and FSH from the pituitary, there are a number of instances in which the secretion of LH and FSH are divergent. Previous studies from our laboratory have indicated that pulsatile LH and FSH secretion are independently regulated by gonadal factors. We have, therefore, ...

journal_title：Endocrinology

authors： Culler MD,Negro-Vilar A

更新日期：1986-02-01 00:00:00

abstract：:The mechanism of the inhibitory effect of long term treatment with estradiol on dopamine synthesis in tuberoinfundibular dopaminergic (TIDA) neurons was studied by using hypothalamic slices from ovariectomized rats. Treatment with 2 mg estradiol valerate (EV) at a 3-week interval increased the weight of the anterior p...

journal_title：Endocrinology

authors： Arita J,Kimura F

更新日期：1987-08-01 00:00:00

abstract：:GH secretion is altered by exercise in humans. In an attempt to investigate the underlying mechanisms, we developed a rodent model. GH secretion was assayed in male and female rats that were sedentary (not exercised), acutely exercised, and chronically exercised. Sedentary males showed typical pulsatile GH secretion. ...

journal_title：Endocrinology

authors： Butkus JA,Brogan RS,Giustina A,Kastello G,Sothmann M,Wehrenberg WB

更新日期：1995-06-01 00:00:00