Parathyroid hormone-related protein and interleukin-1 alpha synergistically stimulate bone resorption in vitro and increase the serum calcium concentration in mice in vivo.

abstract：:Recent studies using twins and inbred strains of mice reveal evidence for genetic mechanisms contributing to variation in circulating levels of IGF-I, IGF-II, and IGF binding protein (IGFBP)-3. To examine the hypothesis that serum IGFBP-5 levels have a strong heritable component, we intercrossed two inbred strains of ...

journal_title：Endocrinology

authors： Mohan S,Masinde G,Li X,Baylink DJ

更新日期：2003-08-01 00:00:00

abstract：:It has been postulated that the rate of hepatic very low density lipoprotein (VLDL) apolipoprotein (apo) B secretion is dependent upon the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. To test this hypothesis in vivo, apoB kinetic studies were carried out in miniature pigs before and after 21 ...

journal_title：Endocrinology

authors： Burnett JR,Wilcox LJ,Telford DE,Kleinstiver SJ,Barrett PH,Newton RS,Huff MW

更新日期：1999-11-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) is produced by the vascular smooth muscle cells (SMCs) of injured and atherosclerotic arteries, in which it may exert autocrine control over SMCs by binding to its principal receptors, NPR-B and NPR-C, but few studies have examined the factors that regulate CNP expression in human SMCs...

journal_title：Endocrinology

authors： Mendonça MC,Doi SQ,Glerum S,Sellitti DF

更新日期：2006-09-01 00:00:00

abstract：:A mitochondrial fraction prepared from homogenates of rat hypothalamic tissue was found by means of electron microscopy to be enriched with synaptosomes. The release of luteinizing hormone releasing hormone (LHRH) and thyrotropin releasing hormone (TRH) from this preparation was investigated. After incubation, the syn...

journal_title：Endocrinology

authors： Warberg J,Eskay RL,Barnea A,Reynolds RC,Porter JC

更新日期：1977-03-01 00:00:00

abstract：:Both starvation and feeding of a low protein diet have dramatic effects on serum thyroid hormone concentrations and on the serum binding proteins for thyroid hormones in rats. We examined whether similar changes might be seen in another model of undernutrition, namely underfeeding without alteration of dietary composi...

journal_title：Endocrinology

authors： Glass AR,Young RA,Anderson J

更新日期：1986-06-01 00:00:00

abstract：:The cytokine interleukin-1 (IL-1) has numerous actions in brain, including pronounced neuroendocrine effects. Recent radioligand binding studies have identified high-affinity binding sites for 125I-recombinant human IL-1 alpha in the hippocampus with characteristics similar to those of IL-1 receptors in immune cells. ...

journal_title：Endocrinology

authors： Cunningham ET Jr,Wada E,Carter DB,Tracey DE,Battey JF,De Souza EB

更新日期：1991-05-01 00:00:00

abstract：:Kisspeptin neurons play an essential role in the regulation of fertility through direct regulation of the GnRH neurons. However, the relative contributions of the two functionally distinct kisspeptin neuron subpopulations to this critical regulation are not fully understood. Here we analyzed the specific projection pa...

journal_title：Endocrinology

authors： Yip SH,Boehm U,Herbison AE,Campbell RE

更新日期：2015-07-01 00:00:00

abstract：:Maternal nutrition can affect the susceptibility of the offspring to metabolic disease later in life, suggesting that this period is a window of opportunity for intervention to reduce the risk of metabolic disease. Resveratrol, a natural polyphenol, has a wide range of beneficial properties including anti-obesogenic, ...

journal_title：Endocrinology

authors： Ros P,Díaz F,Freire-Regatillo A,Argente-Arizón P,Barrios V,Argente J,Chowen JA

更新日期：2020-08-01 00:00:00

abstract：:We have studied potential mechanisms by which zinc deficiency (ZD) may result in growth impairment in young animals. Dietary-induced ZD in young rats resulted in diminished skeletal growth as measured by tibial epiphyseal width. Treatment with bovine GH (bGH) did not increase skeletal growth suggesting GH resistance r...

journal_title：Endocrinology

authors： Oner G,Bhaumick B,Bala RM

更新日期：1984-05-01 00:00:00

abstract：:Changes in insulin, somatostatin, and glucagon secretion during the development of obesity in rats after ventromedial hypothalamic (VMH) lesions were evaluated by measuring fasting hormone levels and their secretion from the isolated perfused pancreas. Fasting peripheral insulin levels were not altered 1 week after th...

journal_title：Endocrinology

authors： Seino Y,Seino S,Takemura J,Tsuda K,Nishi S,Ishida H,Seno M,Usami M,Ikeda M,Imura H

更新日期：1984-02-01 00:00:00

abstract：:The ability of a monoclonal antiidiotypic antibody (clone 1D5) directed against the binding site of a monoclonal antiestradiol antibody to interact with the estrogen receptor (ER) was investigated. The following lines of evidence indicate that clone 1D5 has the capacity of mimicking the actions of estradiol, and recog...

journal_title：Endocrinology

authors： Mor G,Amir-Zaltsman Y,Barnard G,Kohen F

更新日期：1992-06-01 00:00:00

abstract：:Effects of thyroid hormone on proteoglycan degradation in various regions of cartilage were investigated. In propylthiouracil-treated rats with hypothyroidism, proteoglycan degradation in epiphyseal cartilage during endochondral ossification was markedly suppressed. However, injections of T(4) reversed this effect of ...

journal_title：Endocrinology

authors： Makihira S,Yan W,Murakami H,Furukawa M,Kawai T,Nikawa H,Yoshida E,Hamada T,Okada Y,Kato Y

更新日期：2003-06-01 00:00:00

abstract：:Three different experimental approaches were used to assess the regions on the beta-subunit of human FSH (hFSH beta) that may be altered or masked by its association with the alpha-subunit of hFSH (hFSH alpha) in the heterodimeric hFSH molecule. In a direct approach, we tested whether synthetic peptides corresponding ...

journal_title：Endocrinology

authors： Vakharia DD,Dias JA,Andersen TT

更新日期：1991-04-01 00:00:00

abstract：:A central step in the development and sexual differentiation of the brain is the intraneuronal conversion of testosterone to estrogen. This conversion is catalyzed by an enzyme complex comprised of cytochrome P450 aromatase and the ubiquitous NADPH-dependent cytochrome P450 reductase. Brain aromatase activity is devel...

journal_title：Endocrinology

authors： Lauber ME,Lichtensteiger W

更新日期：1994-10-01 00:00:00

abstract：:Estrogen regulates the function, growth, and proliferation of lactotropes in the pituitary. We report here that low-density lipoprotein (LDL) receptor (LDLR) gene expression and LDL uptake are strongly up-regulated by estrogen in pituitary somatolactotropic GH(3) cells. The uptake of LDL was significantly inhibited by...

journal_title：Endocrinology

authors： Smith PM,Cowan A,White BA

更新日期：2004-07-01 00:00:00

abstract：:Biological actions of natriuretic peptide (NP) are determined by the condition of the receptor as well as that of the hormone. Although we previously demonstrated in hypertensive rats the up-regulation of NP-A receptor that mediates various biological actions of NPs, the pathophysiologic significance of NP-C receptor,...

journal_title：Endocrinology

authors： Yoshimoto T,Naruse M,Naruse K,Shionoya K,Tanaka M,Tanabe A,Hagiwara H,Hirose S,Muraki T,Demura H

更新日期：1996-03-01 00:00:00

abstract：:To assess a potential underlying rhythm in the sensitivity of the pregnant primate myometrium to oxytocin we infused five pregnant rhesus monkeys (gestational age, 121-142 days) with oxytocin at three different periods of the 24-h day, in the order night, afternoon, and morning, via the maternal inferior vena cava. Ox...

journal_title：Endocrinology

authors： Honnebier MB,Myers T,Figueroa JP,Nathanielsz PW

更新日期：1989-09-01 00:00:00

abstract：:Stimulation of mitogenesis in rat Nb2 node lymphoma cells by human (h) PRL was inhibited by inhibitors of Na+/H+ exchange (viz. amiloride and its analogs) and inhibitors of protein kinases (isoquinolinesulfonamide derivatives). The most potent were ethylisopropylamiloride (EP-Am) (IC50, 13 microM) and H-7, selective f...

journal_title：Endocrinology

authors： Too CK,Walker A,Murphy PR,Cragoe EJ Jr,Jacobs HK,Friesen HG

更新日期：1987-10-01 00:00:00

abstract：:The CRH-binding protein (CRH-BP) antagonizes the ACTH-releasing activity of the neuropeptide CRH in vitro. However, the function of CRH-BP in vivo and the molecular mechanisms that regulate CRH-BP expression are not well understood. In this study, the rat CRH-BP gene was characterized, and CRH-BP promoter sequences we...

journal_title：Endocrinology

authors： Cortright DN,Goosens KA,Lesh JS,Seasholtz AF

更新日期：1997-05-01 00:00:00

abstract：:In the present study we used characterized perifusion model for the development of homologous desensitization to GnRH in the pituitary gonadotrope. This system relies on immobilized primary pituitary cultures that are perifused with various pulse patterns and concentrations of GnRH; these patterns and concentrations a...

journal_title：Endocrinology

authors： Janovick JA,Conn PM

更新日期：1996-05-01 00:00:00

abstract：:In songbirds, singing behavior is controlled by a discrete network of interconnected brain nuclei known collectively as the song control system. Both the development of this system and the expression of singing behavior in adulthood are strongly influenced by sex steroid hormones. Although both androgenic and estrogen...

journal_title：Endocrinology

authors： Bernard DJ,Bentley GE,Balthazart J,Turek FW,Ball GF

更新日期：1999-10-01 00:00:00

abstract：:We have recently reported that pretreatment with electroacupuncture (EA) at stomach meridian point 36 (St36) prevents the chronic cold-stress increase in the hypothalamus-pituitary-adrenal axis (HPA), an action that may be under central control. Given that treatment for stress-related symptoms usually begins after ons...

journal_title：Endocrinology

authors： Eshkevari L,Mulroney SE,Egan R,Lao L

更新日期：2015-10-01 00:00:00

abstract：:Topiramate (TPM) treatment has been shown to reduce adiposity in humans and rodents. The reduction in adiposity is related to decreased food intake and increased energy expenditure. However, the molecular mechanisms through which TPM induces weight loss are contradictory and remain to be clarified. Whether TPM treatme...

journal_title：Endocrinology

authors： Caricilli AM,Penteado E,de Abreu LL,Quaresma PG,Santos AC,Guadagnini D,Razolli D,Mittestainer FC,Carvalheira JB,Velloso LA,Saad MJ,Prada PO

更新日期：2012-09-01 00:00:00

abstract：:Exposure of quiescent bovine parathyroid cells to serum or a serum substitute caused an elevation in [3H] thymidine incorporation, followed by an increase in cell number. This was preceded by a rapid transient rise in c-myc and c-fos proto-oncogene mRNA levels. Alterations in the medium calcium concentration had no ef...

journal_title：Endocrinology

authors： Kremer R,Bolivar I,Goltzman D,Hendy GN

更新日期：1989-08-01 00:00:00

abstract：:Studies were carried out to determine the origin of the immediate increase in plasma calcium following acute calcitonin deficiency in mature rats. Animals were pre-labelled with 45calcium 24 hours and 4 weeks before thyroparathyroidectomy (TPTX) and 1 hour, 24 hours, 2 and 4 weeks before nephrectomy and TPTX and bled ...

journal_title：Endocrinology

authors： Kalu DN,Hadji-Georgopoulos A,Foster GV

更新日期：1976-02-01 00:00:00

abstract：:Ovarian angiotensin I (Ang I)-converting enzyme (ACE), estimated by the specific binding of the ACE inhibitor [125I]iodo-MK-351A, is localized on multiple ovarian structures, including follicular granulosa cells, corpora lutea, terminal epithelium, and ovarian blood vessels, but total ovarian ACE does not display a cy...

journal_title：Endocrinology

authors： Daud AI,Bumpus FM,Husain A

更新日期：1990-06-01 00:00:00

abstract：:To determine the relative role of the androgenic and/or estrogenic components of the action of dehydroepiandrosterone (DHEA) on the histomorphology and structure of the rat mammary gland, ovariectomized (OVX) female animals received DHEA administered alone or in combination with the pure antiandrogen flutamide or the ...

journal_title：Endocrinology

authors： Sourla A,Martel C,Labrie C,Labrie F

更新日期：1998-02-01 00:00:00

abstract：:During the purification of skeletal growth factor/insulin-like growth factor-II and transforming growth factor-beta (TGF beta) from EDTA extracts of bovine bone matrix significant mitogenic activity for cultured osteoblast (Ob)-like cells eluted in fractions that contained a nearly homogeneous peptide with a mol wt of...

journal_title：Endocrinology

authors： Jennings JC,Mohan S,Baylink DJ

更新日期：1989-07-01 00:00:00

abstract：:Patients with noninsulin-dependent diabetes mellitus exhibit increased proportions of plasma proinsulin and proinsulin conversion intermediates. We used hyperinsulinemic diabetic and nondiabetic Psammomys obesus to study the possible relationship between steady state pancreatic insulin stores and the proportion of pro...

journal_title：Endocrinology

authors： Gadot M,Leibowitz G,Shafrir E,Cerasi E,Gross DJ,Kaiser N

更新日期：1994-08-01 00:00:00

abstract：:Prior published reports have demonstrated that glucose-oxidized low-density lipoproteins (g-OxLDL) enhance the proliferative response of vascular smooth muscle cells (SMC) to IGF-I. Our previous studies have determined that the regulation of cleavage of integrin-associated protein (IAP) by matrix-metalloprotease-2 (MM...

journal_title：Endocrinology

authors： Allen LB,Capps BE,Miller EC,Clemmons DR,Maile LA

更新日期：2009-03-01 00:00:00