Fatal antidepressant overdose among drug abusers and non-drug abusers.

Abstract:

OBJECTIVE:This study examined the predictors, extent and pattern of fatal antidepressant overdose (FAO) in all psychoactive drug-related deaths and compared these in drug abusers and non-drug abusers. METHOD:Inquest data on 491 psychoactive drug-related cases in England and Wales were analysed. We examined predictors of FAO relative to other drug-related deaths in drug abusers and non-abusers using logistic regression, and compared the relative fatality of different antidepressant classes using the Proportionate Fatality Index (PFI). RESULTS:The overall FAO prevalence ratio was 10% (male = 7.1%, female = 18.5%). FAO was twice as likely to occur among cases aged 45 years and over than in younger cases (MOR = 2.6, 95% CI = 1.4-4.9), and eight times more likely to occur in cases with no history of drug abuse (MOR = 8.2, 95% CI = 4.0-18.4). Ingestion of prescribed antidepressants is the only common predictor of FAO among drug abusers and non-abusers, and co-ingestion of a combination of antidepressants of two different classes is a potent risk for FAO in the cases studied. CONCLUSION:The results highlight the need to develop appropriate therapeutic strategies for managing treatment-resistant depression.

journal_name

Acta Psychiatr Scand

authors

Oyefeso A,Valmana A,Clancy C,Ghodse H,Williams H

doi

10.1034/j.1600-0447.2000.102004295.x

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

295-9

issue

4

eissn

0001-690X

issn

1600-0447

journal_volume

102

pub_type

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