Abstract:
OBJECTIVE:This study examined the predictors, extent and pattern of fatal antidepressant overdose (FAO) in all psychoactive drug-related deaths and compared these in drug abusers and non-drug abusers. METHOD:Inquest data on 491 psychoactive drug-related cases in England and Wales were analysed. We examined predictors of FAO relative to other drug-related deaths in drug abusers and non-abusers using logistic regression, and compared the relative fatality of different antidepressant classes using the Proportionate Fatality Index (PFI). RESULTS:The overall FAO prevalence ratio was 10% (male = 7.1%, female = 18.5%). FAO was twice as likely to occur among cases aged 45 years and over than in younger cases (MOR = 2.6, 95% CI = 1.4-4.9), and eight times more likely to occur in cases with no history of drug abuse (MOR = 8.2, 95% CI = 4.0-18.4). Ingestion of prescribed antidepressants is the only common predictor of FAO among drug abusers and non-abusers, and co-ingestion of a combination of antidepressants of two different classes is a potent risk for FAO in the cases studied. CONCLUSION:The results highlight the need to develop appropriate therapeutic strategies for managing treatment-resistant depression.
journal_name
Acta Psychiatr Scandjournal_title
Acta psychiatrica Scandinavicaauthors
Oyefeso A,Valmana A,Clancy C,Ghodse H,Williams Hdoi
10.1034/j.1600-0447.2000.102004295.xsubject
Has Abstractpub_date
2000-10-01 00:00:00pages
295-9issue
4eissn
0001-690Xissn
1600-0447journal_volume
102pub_type
杂志文章abstract::Two groups of former depressed Italian patients comprising 54 bipolars and 52 unipolars completed the Italian version of the EMBU, a Swedish instrument aimed at assessing the experience of parental rearing behaviour. As in a previous study of Swedish depressives, three factors, "rejection", "emotional warmth", and "ov...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1985.tb02591.x
更新日期:1985-08-01 00:00:00
abstract:OBJECTIVE:In the last decade, several studies have suggested that depression is accompanied by increased oxidative stress and decreased antioxidant defenses. We tested the hypothesis that high levels of the antioxidant uric acid are associated with lower risk of hospitalization with depression and use of prescription a...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12793
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Atypical depression may show lowered rather than raised short-term cortisol levels. Atypical major depressive episodes (A-MDE) may also be more closely linked to environmental factors and show overlap with somatic symptom disorders. Hair specimens allow measuring long-term cortisol levels. METHODS:Twenty-se...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,多中心研究
doi:10.1111/acps.12852
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To describe the prevalence of depression according to ICD-10 criteria using a self-completed questionnaire and to identify psychosocial predictors of depression at discharge in patients with acute coronary syndrome. METHOD:A total of 899 patients with acute coronary syndrome completed the Major Depression In...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2004.00430.x
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:To compare the prevalence of Toxoplasma infection between the first-episode schizophrenia and the controls and to compare the clinical features between the Toxoplasma-seronegative and Toxoplasma-seropositive patients with schizophrenia. METHOD:The rate of serum reactivity to Toxoplasma in 600 schizophrenia, ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2006.00780.x
更新日期:2006-07-01 00:00:00
abstract::Psychiatric illness is a significant risk factor for both attempted and completed suicide and psychotropic medications account for 80% of all drug overdoses involving prescription medications. One challenge facing clinicians is to balance the benefit of treatment against the risk of drug overdose. The aim of the prese...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1996.tb10625.x
更新日期:1996-03-01 00:00:00
abstract::In a retrospective study, 124 patients with depression who were concomitantly receiving ECT and benzodiazepines were compared with patients (matched for age, sex, diagnosis, and laterality of ECT) receiving ECT without benzodiazepines in order to investigate the efficacy of ECT in terms of therapeutic response and len...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1996.tb09832.x
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:The main objective of this study was to assess the prevalence of common mental disorders in the Moroccan general population. METHOD:On a systematic representative randomized sample, the Moroccan Arabic version of the Mini International Neuropsychiatric Interview (MINI) was used to assess the prevalence of mo...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2009.01431.x
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Interleukin-1beta (IL-1beta) is released as part of the acute phase immune response and can directly stimulate the release of corticotrophin-releasing hormone and thus induce hypothalamic pituitary adrenal axis hyperactivity. Major depression has been shown to be accompanied by both an acute phase immune resp...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0447.2001.00162.x
更新日期:2001-03-01 00:00:00
abstract::The authors compared 16 nondepressed obsessive-compulsive patients (OCS) with 8 normal controls (NC) of similar age for resting-state regional cerebral glucose metabolic rates (rCMRglu) using positron emission tomography with the fluorodeoxyglucose method. OCS were rated for clinical data, and a neuropsychological bat...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1990.tb03059.x
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVE:Behaviour therapy with exposure and response prevention (ERP) or cognitive behavioural therapy (CBT) including ERP are considered the psychological treatments of choice for obsessive-compulsive disorder (OCD), but group CBT/ERP has received relatively little research attention in the treatment of OCD. The aim...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1600-0447.2008.01270.x
更新日期:2009-02-01 00:00:00
abstract::Fifteen chronic alcoholics and 15 presenile patients were matched in pairs with regard to their mean hemisphere cerebral blood parameters-an index of brain metabolism. The distribution of the regional cerebral blood flow was similar in the two groups. The alcoholics performed significantly better in all psychometric t...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1977.tb00184.x
更新日期:1977-05-01 00:00:00
abstract:OBJECTIVE:To examine the association between preeclampsia and attention-deficit hyperactivity disorder (ADHD), using a large Swedish-based registry cohort. METHODS:This study comprised 2 047 619 children, with 114 934 (5.6%) cases of ADHD. Preeclampsia was based on two alternate definitions: (i) preeclampsia (using IC...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.13162
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:Although previous studies have revealed an association between androgens and aggression, there is a lack of knowledge of this issue in different mental disorders. METHOD:The associations between serum testosterone levels and criminal behaviour in different mental disorders were examined using data collected ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1999.tb07240.x
更新日期:1999-05-01 00:00:00
abstract::In one of the hypotheses on the causes of schizophrenia it is proposed that viruses may play a role in the etiology and pathogenesis of at least some forms of schizophrenia. In our study, 30 healthy adults and 30 schizophrenic patients were investigated for humoral and cellular immunity against herpes simplex virus (H...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1986.tb02739.x
更新日期:1986-06-01 00:00:00
abstract:OBJECTIVE:To determine the longitudinal impact of borderline personality disorder (BPD) on the course and outcome of bipolar disorder (BP) in a pediatric BP sample. METHOD:Participants (N = 271) and parents from the Course and Outcome of Bipolar Youth (COBY) study were administered structured clinical interviews and s...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12415
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Prevalence rates for dissociative disorders among psychiatric in-patients vary widely. The aim of this meta-analysis is to offer an explanation for these differences. METHOD:Prevalence studies using a clinical diagnostic interview among psychiatric in-patients were included. Hypotheses concerning the impact ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,meta分析
doi:10.1034/j.1600-0447.2000.102006423.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To investigate the role of parenting in the development of adult antisocial personality traits. METHOD:A total of 742 community-based subjects were assessed for adult DSM-IV antisocial personality disorder traits and for measures of parental behavior experienced as children, including by the Parental Bonding...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0447.2002.02305.x
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:The relationship between insight and neurocognition in bipolar disorder has not been clearly established. METHOD:A neuropsychological battery assessing attention, mental control, perceptual-motor skills, executive functions, verbal fluency and abstraction, and visuo-spatial attention was administered to 50 b...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2007.01110.x
更新日期:2008-01-01 00:00:00
abstract::In 103 schizophrenic patients we investigated the extent of practice needed in the use of the Brief Psychiatric Rating Scale (BPRS) to enable its reliability to be assessed. The agreement level of the 7 raters was analysed. Generally, the lowest mean agreement found was for the negative symptoms of the BPRS schizophre...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1993.tb03343.x
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:To conduct a systematic review and meta-analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD) compared to healthy controls (HCs). METHOD:The PubMed/MEDLINE, EMBASE, and PsycINFO databases were searched up until May 30, 2016. Effect sizes were esti...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,meta分析
doi:10.1111/acps.12698
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To examine the reliability of a brief instrument to assess coping with symptoms by patients with psychotic illness. METHOD:A semi-structured interview (MACS) was developed to assess the amounts of distress, control and coping in relation to psychotic symptoms. Two raters interviewed 23 symptomatic but stable...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0447.2001.00324.x
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:To identify psychopathological predictors for suicide in a population of major depressed Diagnostic Statistical Manual-III (DSM-III) in-patients. METHOD:A total of 210 previous participants in multicentre antidepressant drug trials, carried out in a randomized double-blind design, were followed prospectively...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2003-06-01 00:00:00
abstract::Psychiatry in Scandinavia has a tradition for research and clinical work with people from other countries, especially related to refugees and survivors after the Second World War. In recent years an increasing number of refugees have arrived, especially from the countries of the Middle East. The aim of this study was ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1989.tb01313.x
更新日期:1989-08-01 00:00:00
abstract:OBJECTIVE:The impact of religious/spiritual activities on clinical outcomes in patients with serious mental illnesses remains controversial, which was addressed in this international cross-sectional study. METHOD:Three-hundred sixty-nine subjects were recruited from Austria (n = 189) and Japan (n = 180), consisting of...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,多中心研究
doi:10.1111/acps.12838
更新日期:2018-04-01 00:00:00
abstract::Lithium is the primary treatment for manic-depressive illness. The mechanism of action of lithium and its endocrine effects remain unclear. Therefore, the hormone responses to sequential stimuli, namely arginine, TRH, and LHRH, were studied in eight patients with major depression before and during treatment with lithi...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1986.tb02720.x
更新日期:1986-05-01 00:00:00
abstract::To explore and to compare hypothalamic-pituitary-somatotropic (HPS), hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-adrenocortical (HPA) axis function in depression, 30 subjects (15 patients with a major depressive episode and individually matched controls) received 50 micrograms growth hormone-releas...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1989.tb10308.x
更新日期:1989-06-01 00:00:00
abstract::Within the framework of the multifactorial-polygenic model of inheritance, multiple threshold strategy was applied to a large set of pedigree data to examine the clinico-genetical position of some subtypes within the ICD-9 classification of schizophrenic psychoses. It appeared highly probable that the ICD-9 subtypes e...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1983.tb07009.x
更新日期:1983-10-01 00:00:00
abstract:OBJECTIVE:Despite comparable antipsychotic exposure, some patients experience involuntary movements yet others do not. Negative symptoms have been associated with tardive dyskinesia (TD), but it is not certain whether this is an association with primary negative symptoms or the effects of medications. The aim of the pr...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2011.01751.x
更新日期:2011-11-01 00:00:00
abstract::In a randomized double-blind study with parallel group design involving 60 anxious psychoneurotic outpatients, the anxiolytic activity of alprazolam was compared with that of oxazepam. Following a 4 to 7-day placebo washout period, both groups showed a similar and significant response to treatment during the 4-week ac...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0447.1987.tb02830.x
更新日期:1987-05-01 00:00:00