Abstract:
OBJECTIVE:To examine the association between preeclampsia and attention-deficit hyperactivity disorder (ADHD), using a large Swedish-based registry cohort. METHODS:This study comprised 2 047 619 children, with 114 934 (5.6%) cases of ADHD. Preeclampsia was based on two alternate definitions: (i) preeclampsia (using ICD-9/ICD-10) and (ii) preeclampsia and small for gestational age (SGA) combined. ADHD was determined in one of two ways: (i) if a diagnosis of ADHD was present in the National Patient Register or (ii) if an individual was in receipt of ADHD medication in the Prescribed Drug Register. Multivariate Cox proportional hazards regression analysis allowed adjustment for several perinatal/sociodemographic factors. Sibling-matched analysis further controlled for shared genetic and familial confounding. RESULTS:In the adjusted Cox model, preeclampsia was associated with an increase in likelihood of ADHD (HR: 1.15, 95% CI: 1.12, 1.19). The HR for preeclampsia and those born SGA was 1.43 (95% CI: 1.31, 1.55) in the adjusted model, compared to those unexposed to preeclampsia/SGA. The sibling-matched analysis did not materially change these associations (HR: 1.13, 95% CI: 1.05, 1.22) and 1.55 (95% CI: 1.28, 1.88). CONCLUSIONS:Exposure to preeclampsia or preeclampsia/SGA was associated with ADHD, independent of genetic/familial factors shared by siblings. However, it is important to note that sibling-matched analysis can only adjust for factors that are constant between pregnancies; therefore, residual confounding cannot be ruled out. Further research is needed to explore modifiable risk factors and identify those most-at-risk babies following delivery.
journal_name
Acta Psychiatr Scandjournal_title
Acta psychiatrica Scandinavicaauthors
Maher GM,Dalman C,O'Keeffe GW,Kearney PM,McCarthy FP,Kenny LC,Khashan ASdoi
10.1111/acps.13162subject
Has Abstractpub_date
2020-10-01 00:00:00pages
275-283issue
4eissn
0001-690Xissn
1600-0447journal_volume
142pub_type
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1986.tb02695.x
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journal_title:Acta psychiatrica Scandinavica
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journal_title:Acta psychiatrica Scandinavica
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Acta psychiatrica Scandinavica
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doi:10.1111/j.1600-0447.1997.tb09936.x
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1981.tb00697.x
更新日期:1981-05-01 00:00:00
abstract::The dexamethasone suppression test (DST) was administered to 30 inpatients who met the DSM-III-R criteria for chronic schizophrenia and shared similar environments. Four of them (13%) were DST nonsuppressors. The mean and maximum postdexamethasone cortisol levels were correlated with the patient's score on the scale f...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1993.tb03485.x
更新日期:1993-12-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0447.1992.tb01432.x
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1978.tb00236.x
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1986.tb06219.x
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journal_title:Acta psychiatrica Scandinavica
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pub_type: 杂志文章
doi:10.1034/j.1600-0447.2001.00162.x
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1997.tb09900.x
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1987.tb05617.x
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,多中心研究
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更新日期:2018-04-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0447.2005.00549.x
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pub_type: 杂志文章
doi:10.1111/j.1600-0447.1994.tb01494.x
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journal_title:Acta psychiatrica Scandinavica
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1988.tb06359.x
更新日期:1988-10-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1983.tb06725.x
更新日期:1983-02-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1989.tb10295.x
更新日期:1989-05-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2007.01110.x
更新日期:2008-01-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12144
更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/acps.13012
更新日期:2019-05-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1991.tb01426.x
更新日期:1991-07-01 00:00:00