Raised levels of plasma interleukin-1beta in major and postviral depression.

Abstract:

OBJECTIVE:Interleukin-1beta (IL-1beta) is released as part of the acute phase immune response and can directly stimulate the release of corticotrophin-releasing hormone and thus induce hypothalamic pituitary adrenal axis hyperactivity. Major depression has been shown to be accompanied by both an acute phase immune response, including raised IL-1beta production and hypothalamic pituitary adrenal axis hyperactivity. In this study the possible role of IL-1beta in major depression and postviral depression was investigated. METHOD:Plasma IL-1beta levels were measured in four groups; patients suffering from postviral depression (n= 17), patients with major depression (n = 20), subjects who were postviral and euthymic (n= 12) and normal controls (n = 20). RESULTS:IL-1beta serum concentrations were significantly elevated in both groups of depressed patients compared to controls. The serum concentrations of IL-1beta were higher in the postviral group than in the major depression group; this difference was not significant. CONCLUSION:These data confirm previous suggestions of elevated IL-1beta levels in major depression and postviral depression. IL-1beta is known to induce depressive symptoms as well as sickness behaviour and may contribute to the hypothalamic pituitary adrenal axis hyperactivity found in mood disorders.

journal_name

Acta Psychiatr Scand

authors

Owen BM,Eccleston D,Ferrier IN,Young AH

doi

10.1034/j.1600-0447.2001.00162.x

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

226-8

issue

3

eissn

0001-690X

issn

1600-0447

pii

acp162

journal_volume

103

pub_type

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