CSF biochemical correlates of mixed affective states.

Abstract:

:To evaluate the question of whether "mixed" bipolar disorder is a distinct entity, we compared selected cerebrospinal fluid (CSF) biochemical parameters from patients with bipolar disorder, mixed, to those with mania and major depression. Fourteen patients in each category (DSM-III) were studied with regard to CSF HVA, 5HIAA, sodium, potassium, calcium, and magnesium levels under carefully controlled conditions. CSF HVA, 5HIAA, and sodium were found to be significantly higher in manics than in major depressives. Discriminant analysis of the biochemical variables of the mixed affective group identified two biochemically distinct and clinically different subgroups of seven patients each, one resembling the manic group and the other the major depressive group. These findings suggest that mixed affective states do not exist as a separate entity, but are composed of two subgroups obtained from the manic and major depressive categories.

journal_name

Acta Psychiatr Scand

authors

Tandon R,Channabasavanna SM,Greden JF

doi

10.1111/j.1600-0447.1988.tb06339.x

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

289-97

issue

3

eissn

0001-690X

issn

1600-0447

journal_volume

78

pub_type

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