Abstract：
OBJECTIVE:Given the familial influences on schizophrenia, it may be hypothesized that specific symptom domains also cluster within families, and that this applies to both clinical and subclinical levels of expression. This hypothesis was put to the test in a group of patients with a DSM-IV diagnosis of psychotic disorder together with their unaffected siblings, and a group of healthy sib-pairs. METHOD:Subclinical positive, negative and depressive symptoms in relatives and healthy controls were assessed with the Community Assessment of Psychic Experiences (CAPE). Positive and negative schizotypy in relatives and controls was measured with the Structured Interview for Schizotypy-Revised. Multilevel linear regression analyses were conducted to investigate clustering of symptom dimensions within patient-relative sib-pairs (N = 811 pairs), healthy sib-pairs of affected families (N = 136 pairs) and healthy control sib-pairs (N = 58 pairs). RESULTS:Familial clustering of symptoms was found in all three groups. Effect sizes were largest in healthy control sib-pairs, smallest in patient-relative sib-pairs and intermediate in healthy sib-pairs of affected families. CONCLUSION:Studies of sibling associations in genetic studies of psychometric expression of psychosis liability need to take into account the fact that the higher levels of background genetic risk and presence of diagnosed illness are inversely associated with sibling associations.
journal_name
Acta Psychiatr Scandjournal_title
Acta psychiatrica Scandinavicaauthors
Lataster T,Verweij K,Viechtbauer W,GROUP.doi
10.1111/acps.12102subject
Has Abstractpub_date
2014-01-01 00:00:00pages
44-53issue
1eissn
0001-690Xissn
1600-0447journal_volume
129pub_type
杂志文章abstract：:A total of 289 Greenlanders admitted for the first time to a mental hospital from 1980 to 1983, were followed for 7 years. Thirty-seven patients, 24 men and 13 women, were diagnosed with schizophrenia at least once during the follow-up period. The annual first admission rate per 100,000 was 41 for men and 23 for women...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1995.tb09802.x
更新日期：1995-06-01 00:00:00
abstract：:Twenty-five DSM-III-diagnosed schizophrenics and 37 normal and age-matched controls were examined using an oddball paradigm for the generation of P300 and smooth eye-pursuit tasks. Results were compared between groups and related to clinical characteristics, including a family history of psychiatric illness. Group dif...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1990.tb01385.x
更新日期：1990-10-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of depression in a community with 15 000 inhabitants in Brazil (Bambuí). METHOD:The Composite International Diagnostic Interview was applied in a random sample of 1041 residents aged 18+ years. RESULTS:The ICD-10 1-month, 1-year and lifetime prevalences of depression were 8.2% (9...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1034/j.1600-0447.2001.00440.x
更新日期：2001-10-01 00:00:00
abstract：OBJECTIVE:The endocannabinoid (EC) system is widely distributed throughout the brain and modulates many functions. It is involved in mood and related disorders, and its activity may be modified by exogenous cannabinoids. This article examines the therapeutic potential of cannabinoids in psychiatric disorders. METHOD:A...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0447.2011.01687.x
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:Schizophrenia is associated with alterations in blood inflammatory markers, including cytokines. Total white blood cell (WBC) count is a marker of low-grade inflammation. We conducted a meta-analysis of total and differential WBC counts in patients with schizophrenia. METHOD:Articles were identified through ...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/acps.13140
更新日期：2020-07-01 00:00:00
abstract：:A study of monozygotic (MZ) and dizygotic (DZ) twins was undertaken to assess further the properties of the Parental Bonding Instrument (PBI), a self-report measure of parental care and overprotection, to examine for associations between PBI and mood (trait anxiety and depression) scores, and to assess the genetic con...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1986.tb02660.x
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVE:The aim of this review is to summarize all data on suicidal behaviour reported in the Bible and to discuss basic implications for medical ethical positions. METHOD:All books of the Jerusalem Bible, including the apocrypha accepted in the Catholic canon, were searched for all cases of suicide, attempted suici...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.2005.00567.x
更新日期：2005-09-01 00:00:00
abstract：:A marked proportion of primary care patients have mental disorders and problems that remain unrecognized by the patients and their general practitioners. There is furthermore a great variation in the physicians' ability to detect mental disorders. The aim of the present study was to find out the overall prevalence of ...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1994.tb01522.x
更新日期：1994-05-01 00:00:00
abstract：:Interviews were conducted with 21 patients classified as neurotic or prepsychotic/psychotic, consecutively admitted to an intensive care unit (ICU) owing to suicide attempts by means of drug intoxication, with their 37 significant others and with care personnel concerning the patients' contacts with psychiatric, somat...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1987.tb02803.x
更新日期：1987-04-01 00:00:00
abstract：:In order to evaluate the effect of training primary health care (PHC) physicians to recognize mental disorders, an intervention randomized controlled trial was conducted. Three categories of PHC physicians were selected: the index group (n = 12 doctors), control group 1 (n = 12) and control group 2 (n = 4). For 1 week...
journal_title：Acta psychiatrica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-0447.1997.tb09945.x
更新日期：1997-12-01 00:00:00
abstract：OBJECTIVE:The follow-up since 1989 of a large sample of multigenerational families of eastern Québec that are densely affected by schizophrenia (SZ) or bipolar disorder (BP) has permitted to look at the rates of DSM diagnoses in the young offspring of a SZ parent (HRSZ) and of a BP parent (HRBP) who had an extremely lo...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.2007.01125.x
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:The paper provides the first syllabus on the prevalence of mental disorders in old-age focusing on surveys conducted in the 15 countries, which comprised the 'old' European Union. METHOD:A systematic search of the literature published from 1990 onwards was conducted. RESULTS:Mental disorders in old-age are ...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0447.2005.00632.x
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:Behaviour therapy with exposure and response prevention (ERP) or cognitive behavioural therapy (CBT) including ERP are considered the psychological treatments of choice for obsessive-compulsive disorder (OCD), but group CBT/ERP has received relatively little research attention in the treatment of OCD. The aim...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1600-0447.2008.01270.x
更新日期：2009-02-01 00:00:00
abstract：:Drug use and psychiatric symptoms were independently assessed in a random sample of 177 adolescents from a junior high school population. Pupils who used cigarettes, alcohol, cannabis, solutions (sniffing), and tranquilizers, all had higher frequencies of psychiatric symptoms than non-users. The use of alcohol was sho...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1986.tb02708.x
更新日期：1986-04-01 00:00:00
abstract：:The case of an autopsied patient with hypophyseal prolactinoma and dermatozoic delusions is reported, and the mechanism of onset of this special form of delusion is discussed from the neuroendocrinological view point, including response to medications, and neuropathological and pituitary hormonal studies. The subject ...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1985.tb02641.x
更新日期：1985-11-01 00:00:00
abstract：:This article reviews the 1980's literature on gender differences in schizophrenia outcome. Neuroleptic response, long-term course, and housing, appear to be superior in women. Mortality ratios are advantageous to schizophrenic men. After menopause, women may require higher neuroleptic doses than men and are more at ri...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1986.tb02732.x
更新日期：1986-06-01 00:00:00
abstract：:The first (or menstrual) and fourth (or premenstrual) week of the menstrual cycle may be associated with many suicide attempts in women. The study sample included 113 Spanish women who attempted suicide and contacted an emergency service. Inclusion criteria were as follows: fertility; regular menstrual cycles; lack of...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1998.tb09959.x
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:Cannabis is an acknowledged risk factor for some mental disorders, but for others the evidence is inconclusive. Prescribed medicinal drugs can be used as proxies for mental disorders. In this study, we investigate how use of cannabis is prospectively related to prescription of antipsychotics, mood stabilizers...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/acps.13104
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:To determine if the Beliefs about Medicines Questionnaire (BMQ) has satisfactory psychometric properties in patients with severe mental disorders and if their scores differ from those of patients with severe medical disorders. To investigate if the scores are related to medication adherence. METHOD:Two hundr...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.2008.01279.x
更新日期：2009-01-01 00:00:00
abstract：:Salivary secretion was measured in 54 psychiatric patients comprising four diagnostic groups: schizophrenia, mania, depression and anxiety state. Detailed psychometric assessment was carried out at the time of measurement. Although salivary flow failed to show an association with either diagnostic category or mental s...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1979.tb00253.x
更新日期：1979-05-01 00:00:00
abstract：:A 3-year urban material of suicides in adolescents and young adults (age 15-29 years) was studied retrospectively by means of interviews with survivors (n = 58). Classification of mental disorders according to DSM-III-R showed that major depression was important as background to suicides in 41%, primary (22%) or secon...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1989.tb10292.x
更新日期：1989-05-01 00:00:00
abstract：:In this study a newly developed Self-rating Inventory for Posttraumatic Stress Disorder (PTSD) is presented. The instrument consists of 47 items, reflecting DSM-III-R criteria, associated features and items corresponding to the disorder of extreme stress not otherwise specified. All items are phrased in a trauma-indep...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1994.tb01574.x
更新日期：1994-09-01 00:00:00
abstract：:Beck's Depression Inventory was administered in a study of all students aged 16-17 years in the first year of high school in a Swedish town, and was completed by 93% of them (n = 2270). Cronbach's reliability coefficient alpha was 0.89, and there were strong correlations between item scores and total scores. A diagnos...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1997.tb09632.x
更新日期：1997-04-01 00:00:00
abstract：:Zuclopenthixol decanoate (ZPT-D) and haloperidol decanoate (HAL-D) were compared in the maintenance treatment of chronic schizophrenic patients. All patients were treated with either ZPT-D or HAL-D for at least 3 months and were then randomly allocated to treatment with either ZPT-D (100-600 mg every 4 weeks) or HAL-D...
journal_title：Acta psychiatrica Scandinavica
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1600-0447.1991.tb01414.x
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:Atypical depression may show lowered rather than raised short-term cortisol levels. Atypical major depressive episodes (A-MDE) may also be more closely linked to environmental factors and show overlap with somatic symptom disorders. Hair specimens allow measuring long-term cortisol levels. METHODS:Twenty-se...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章,多中心研究
doi：10.1111/acps.12852
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:To examine whether bipolar disorder patients who stop cannabis use during a manic/mixed episode have better clinical and functional outcomes than continued use or never use. METHOD:Data from the European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM), a 2-year prospective observational study...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/acps.12366
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:Relocations after disasters are known to cause added distress in survivors. This study examined the effects of migration and other factors on psychological status of survivors 4 years after the two severe earthquakes in Turkey. METHOD:Five hundred and twenty-six adult survivors of the 1999 earthquakes curren...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.2006.00786.x
更新日期：2006-09-01 00:00:00
abstract：:An intensive 1-year study was carried out on 41 male patients, mean age 49, mean hospitalization time 49 days, admitted to a special ward of the Beckomberga Hospital with the diagnosis of delirium tremens and 50 concomitant somatic and psychiatric diagnoses (1--9 per capita), and given a standardized treatment. The me...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1980.tb00616.x
更新日期：1980-10-01 00:00:00
abstract：:An indepth study was carried out over 1 year on all instances of overt heterosexual interactions among acute psychiatric patients on mixed-sex intensive treatment units. Sixteen of the 1060 patients treated on the units were involved in nine instances of overt heterosexual interactions. Analysis of the interactions sh...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1981.tb00804.x
更新日期：1981-11-01 00:00:00
abstract：:Thirty-seven patients with the diagnosis of senile dementia and 70 children aged 6 months to 4 years were observed in three tasks that stimulated exploratory behavior. The subjects were rated according to the frequencies of certain forms of behavior in 52 variables. It was assumed that certain behavior would be more f...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
