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Clinical diagnoses in young offspring from eastern Québec multigenerational families densely affected by schizophrenia or bipolar disorder.

Abstract：

OBJECTIVE:The follow-up since 1989 of a large sample of multigenerational families of eastern Québec that are densely affected by schizophrenia (SZ) or bipolar disorder (BP) has permitted to look at the rates of DSM diagnoses in the young offspring of a SZ parent (HRSZ) and of a BP parent (HRBP) who had an extremely loaded family history. METHOD:The sample (average age of 17.5, SD 4.5) consisted of 54 high-risk offspring (HR) having one parent affected by a DSM-IV SZ or BP. The parents descended from 21 multigenerational families that constitute a quasi-total sample of such kindred in eastern Québec. The HRs were administered a lifetime best estimate DSM-IV diagnosis. RESULTS:We observed that the rates, the diversity of diagnoses, the high comorbidity, the severity and the age of onset of the clinical diagnoses tended to be similar with those already reported in the offspring of affected parents with a low familial loading. Although the sample size was small, HRSZ and HRBP also tended to show similarities in their clinical status. CONCLUSION:Overall, taking into account methodological limitations, the observation early in life of some shared characteristics among HRSZ and HRBP in terms of non-psychotic diagnosis may be congruent with the accumulating evidence that several phenotypic features are shared in adulthood by the two major psychoses.

journal_name

Acta Psychiatr Scand

journal_title

Acta psychiatrica Scandinavica

authors

Maziade M,Gingras N,Rouleau N,Poulin S,Jomphe V,Paradis ME,Mérette C,Roy MA

doi

10.1111/j.1600-0447.2007.01125.x

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

118-26

issue

2

eissn

0001-690X

issn

1600-0447

pii

ACP1125

journal_volume

117

pub_type

杂志文章

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