Abstract:
OBJECTIVE:Our analysis aimed at comparing the placebo effect sizes from randomized controlled trials (RCTs) of two widely prescribed antidepressants, namely duloxetine and venlafaxine, and at analysing a potential influence of the investigated drugs on the placebo response. METHOD:We conducted a comprehensive systematic review and meta-analysis of placebo-controlled, double-blind RCTs, which examined the efficacy of duloxetine and venlafaxine in the acute treatment of major depressive disorder. RESULTS:We included 71 studies (29 duloxetine trials and 43 venlafaxine trials; one study provided data for the duloxetine and the venlafaxine data set). The placebo effect sizes, defined as pre-postscore change divided by baseline standard deviation, differed significantly between venlafaxine and duloxetine studies (-2.51 vs. -2.09; test for subgroup differences P = 0.028; high heterogeneity). The analysis of effect modifiers and the metaregression analyses confirmed the drug, next to baseline depression severity and publication status, as the most influential independent predictor. CONCLUSION:Our analyses show a significant difference in the placebo response between venlafaxine and duloxetine trials and suggest that the investigated drug has an influence on the placebo response that is not related to baseline severity, changes over the years or other variables we included.
journal_name
Acta Psychiatr Scandjournal_title
Acta psychiatrica Scandinavicaauthors
Breilmann J,Furukawa TA,Becker T,Koesters Mdoi
10.1111/acps.12881subject
Has Abstractpub_date
2018-06-01 00:00:00pages
472-480issue
6eissn
0001-690Xissn
1600-0447journal_volume
137pub_type
杂志文章,meta分析abstract::The aim of this study was to investigate whether there is any correlation between negative experiences in early infancy and the later occurrence of psychiatric disorders. The subjects in this study were a cohort of 2,215 adoptees born 1930-1949. Information about the probands' early experiences has been obtained from ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1982.tb00848.x
更新日期:1982-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to identify psychopathological factors associated with long-term functional outcome in euthymic bipolar disorder patients and to test new measures of mood instability and symptoms intensity. METHOD:Fifty-five patients with more than 12 months of follow-up were included. In addition ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12065
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the efficacy of zotepine in the treatment of acute episodes of schizophrenia. METHOD:Patients with acute exacerbation of schizophrenia (DSM-III-R criteria; n = 158) were allocated on a random, double-blind basis to receive zotepine (150 or 300 mg/day), chlorpromazine (30...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:The neurotransmitter serotonin (5-HT) has been linked to the underlying biological processes related to aggressive behaviour. However, only a few studies on this subject involving young people have been published so far. METHOD:We aimed to investigate the effects of acute tryptophan depletion (ATD) on reacti...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/acps.12001
更新日期:2013-08-01 00:00:00
abstract::Paranoid states beginning in middle life were selected from a case register. A search among the sibs of those probands uncovered no paranoid states and schizophrenia was no more common than in the general population. The implications for the aetiology of paranoid states and for the relationship between these and schiz...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1980.tb00880.x
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:To examine the risk factors for suicidal behaviour in human immunodeficiency virus (HIV) positive patients. METHOD:HIV substance dependent positive patients who had attempted suicide were compared with HIV substance dependent positive patients who had never attempted suicide for suicide risk factors. RESULT...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0447.2003.02033.x
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To examine the association between different levels of childhood attention deficit hyperactivity disorder (ADHD) symptoms and sex differences in psychosocial outcomes during adolescence. METHOD:Swedish children (n = 4635) were screened for neuropsychiatric symptoms at age 9 or 12. ADHD symptoms were divided ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12655
更新日期:2016-12-01 00:00:00
abstract::Bright-light therapy is widely regarded as an effective treatment for winter seasonal affective disorder (SAD). We attempted to identify predictors of light therapy response in 54 depressed, drug-free outpatients diagnosed with SAD by DSM-III-R criteria. After a baseline week, patients were treated for 2 weeks with 25...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1994.tb01494.x
更新日期:1994-02-01 00:00:00
abstract::Despite the atheoretical approach of the DSM-III-R, the personality disorders have their roots in specific theoretical schools. Due to clinical tradition, analogies with Axis I and the tradition in psychiatry and medicine, the personality disorders are presented as categories although there is more empirical support f...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1993.tb03436.x
更新日期:1993-09-01 00:00:00
abstract::The authors have repeated, on the average 29.7 years later, Rorschach test in 11 schizophrenic men and 19 schizophrenic women. This work was carried out in the course of a follow-up study of schizophrenics more than 65 years of age. Analysis of the records showed that the only differences between the first and second ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1976.tb00071.x
更新日期:1976-03-01 00:00:00
abstract:OBJECTIVE:About one-third of patients referred to services for people at high risk for psychosis may have already developed a first episode of psychosis (FEP). We compared clinical outcomes in FEP patients who presented to either high risk or conventional mental health services. METHOD:Retrospective study comparing du...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12480
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to ascertain whether suicide victims had ever been in contact with a primary health-care centre, a psychiatric out-patient treatment centre or any form of institutional psychiatric care, and whether there had been any change in such patterns over time. The results show an increase in the numb...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1996.tb10675.x
更新日期:1996-06-01 00:00:00
abstract::This study set out to describe the sexual attitudes and behaviour of 50 hospitalized alcoholic men by comparing them with a sample of the general population, matched in age and social class. This control sample was identified by random selection from a company register, and subjects were recruited into the study with ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1978.tb00236.x
更新日期:1978-10-01 00:00:00
abstract::The present study was designed to test the hypothesis of "schizophrenic spectrum" disorders. The families of 60 process schizophrenics were systematically interviewed with structured interview forms, and evaluated for psychiatric illness according to strict diagnostic criteria. The interviewed persons were then separa...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1975.tb00001.x
更新日期:1975-03-01 00:00:00
abstract::Our clinical experience that lithium is an agent used infrequently for self-poisoning was investigated. The rate at which such overdoses occurred was determined from hospital records. A retrospective case notes study then compared overdose rates in patients taking lithium versus patients on antidepressant medication. ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1994.tb01555.x
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:To investigate the durability of positive effects of cognitive behaviour therapy (CBT) with coping training on psychotic symptoms and social functioning. METHOD:Forty patients with schizophrenia or related psychotic disorders and refractory auditory hallucinations were given CBT and coping training in an int...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0447.2001.00213.x
更新日期:2001-05-01 00:00:00
abstract:INTRODUCTION:This paper reviews studies on outcomes of involuntary hospital admissions in general adult psychiatry, and predictors of outcomes. METHOD:Studies assessing observer-rated clinical change and self-rated outcomes were identified. Relevant databases were searched and authors were contacted. Studies were clas...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0447.2006.00823.x
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:To examine secular trends in the prevalence of Alzheimer's disease (AD) and vascular dementia (VD) in a general Japanese population. METHOD:Four cross-sectional examinations were conducted among residents of a Japanese community aged >or=65 in 1985, 1992, 1998 and 2005. RESULTS:The age- and sex-adjusted pre...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2010.01587.x
更新日期:2010-10-01 00:00:00
abstract::Abnormal glucose tolerance is often found in patients with anorexia nervosa (AN). We attempted to evaluate pancreatic B-cell functioning after intravenous glucagon administration. Fourteen patients with the restricting type of AN (percentage of ideal body weight 71.5 +/- 1.6%, mean +/- SE) and 6 patients with the buli...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1992.tb01433.x
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To examine the association between preeclampsia and attention-deficit hyperactivity disorder (ADHD), using a large Swedish-based registry cohort. METHODS:This study comprised 2 047 619 children, with 114 934 (5.6%) cases of ADHD. Preeclampsia was based on two alternate definitions: (i) preeclampsia (using IC...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.13162
更新日期:2020-10-01 00:00:00
abstract::For patients dependent on benzodiazepines alone, or in combination with alcohol and/or other legal and illegal drugs, observed mortality rates were compared with the average population, and, in cases of isolated benzodiazepine dependence, also with a control group of non-dependent patients chosen to match each depende...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1986.tb02693.x
更新日期:1986-03-01 00:00:00
abstract:OBJECTIVE:To study autism over time in order to ascertain whether there has been an increase in its prevalence in recent years. METHOD:All English language papers on the prevalence of autism were reviewed. Ten of the studies retrieved were not used in the final analysis because they did not meet full criteria for incl...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0447.1999.tb00984.x
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:A higher incidence of childhood trauma (CT) has been reported in first episode of psychosis (FEP). There is, however, a lack of knowledge about the synergetic effect between CT and recent stressful events (RSE). METHODS:Information on specific types of CT (under 17 years) and RSE (within the past 3 years) w...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.13114
更新日期:2020-01-01 00:00:00
abstract::Speech recordings were made of 16 depressed patients during depression and after clinical improvement. The recordings were analyzed using a computer program which extracts acoustic parameters from the fundamental frequency contour of the voice. The percent pause time, the standard deviation of the voice fundamental fr...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1987.tb02891.x
更新日期:1987-09-01 00:00:00
abstract::In this research we investigated the effects of 4 antipsychotic drugs with different anticholinergic components on different memory functions of schizophrenic patients. Drugs were administered in cumulative doses and memory was tested 90 min after each drug was administered. The results show that chlorpromazine and th...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0447.1992.tb01446.x
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To combine the results of earlier comparison studies of in-patient aggression to quantitatively assess the strength of the association between patient factors and i) aggressive behaviour,ii) repetitive aggressive behaviour. METHOD:A systematic review and meta-analysis of empirical articles and reports of com...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,meta分析,评审
doi:10.1111/acps.12053
更新日期:2013-04-01 00:00:00
abstract::The construction of the clinical category dysmorphophobia (now known as body dysmorphic disorder) resulted from the historical convergence of a neologism (coined by Enrico Morselli), a family of clinical concepts (already available during the late 19th century), and a specifiable behaviour (an 'attitude' towards part ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 传,历史文章,杂志文章
doi:10.1111/j.1600-0447.1996.tb09817.x
更新日期:1996-07-01 00:00:00
abstract::Plasma concentrations of barbital and diazepam were measured daily during a double-blind study of the efficacy of the two drugs in the treatment of delirium tremens and less severe clinical states. Treatment was estimated as satisfactory in the majority of cases; the present study deals with the satisfactory groups on...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0447.1979.tb06966.x
更新日期:1979-03-01 00:00:00
abstract::Sleep disturbances commonly occur in the premenstruum in both Premenstrual Syndrome (PMS) patients and in women from the general population. Reports on the Post-Sleep Inventory were obtained from a clinic sample of PMS patients and samples from the general population dichotomized into a non-clinic group with and witho...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1988.tb06304.x
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to relate measures of psychoanalytically derived personality traits to descriptive diagnosis and psychopathology in severe mental disorders. METHOD:Sixty-one consecutive first-episode patients with schizophrenia, bipolar disorder and severe major depression were interviewed. Persona...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2003.00289.x
更新日期:2004-03-01 00:00:00