A placebo-controlled comparison of zotepine versus chlorpromazine in patients with acute exacerbation of schizophrenia.

Abstract:

OBJECTIVE:The aim of this study was to evaluate the efficacy of zotepine in the treatment of acute episodes of schizophrenia. METHOD:Patients with acute exacerbation of schizophrenia (DSM-III-R criteria; n = 158) were allocated on a random, double-blind basis to receive zotepine (150 or 300 mg/day), chlorpromazine (300 or 600 mg/day) or placebo for 8 weeks. Symptoms were assessed on the BPRS, SANS and CGI scales at baseline and weeks 1, 2, 4, 6 and 8 and patients were assessed at these times for adverse effects. Analysis was by analysis of variance on the intent-to-treat population, with last observation carried forward. RESULTS:Mean BPRS scores improved statistically significantly more with zotepine than chlorpromazine (point estimate of difference -12.4, 95% CI -18.3 to -6.5) or placebo (point estimate of difference -12.7, 95% CI -18.6 to -6.8). Zotepine produced significantly fewer extrapyramidal symptoms (EPS) than chlorpromazine. CONCLUSION:Zotepine is an effective antipsychotic with low propensity for EPS.

journal_name

Acta Psychiatr Scand

authors

Cooper SJ,Tweed J,Raniwalla J,Butler A,Welch C

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

218-25

issue

3

eissn

0001-690X

issn

1600-0447

journal_volume

101

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    doi:10.1111/j.1600-0447.1978.tb00236.x

    authors: Whalley LJ

    更新日期:1978-10-01 00:00:00

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    doi:10.1111/j.1600-0447.1999.tb00984.x

    authors: Gillberg C,Wing L

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    journal_title:Acta psychiatrica Scandinavica

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    doi:10.1111/j.1600-0447.1997.tb09900.x

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    更新日期:2004-08-01 00:00:00

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    更新日期:1996-09-01 00:00:00

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    journal_title:Acta psychiatrica Scandinavica

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    doi:10.1111/j.1600-0447.1984.tb04515.x

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    更新日期:1984-01-01 00:00:00

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    pub_type: 杂志文章

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    authors: Langevin R,Paitich D,Orchard B,Handy L,Russon A

    更新日期:1982-09-01 00:00:00

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    更新日期:1986-05-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1991-01-01 00:00:00

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    pub_type: 杂志文章,多中心研究

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    更新日期:1991-05-01 00:00:00

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    更新日期:1983-06-01 00:00:00

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    pub_type: 杂志文章,meta分析,评审

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    更新日期:1985-02-01 00:00:00

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    更新日期:1992-09-01 00:00:00