Comparison of participants and nonparticipants in a neuroendocrine investigation of psychosis.

Abstract:

:Of all neuroleptic-naive, acutely psychotic subjects admitted to hospital over a 2-year period (n = 62), 27 participated in a neuroendocrine study and 35 did not participate (51% refused consent, 19% were incapable of consent and 31% started neuroleptics immediately). However, all nonparticipants agreed to psychopathological evaluation, thus allowing comparison between participants and nonparticipants. The 2 groups were similar in most respects, except that more nonparticipants were hostile. Among subjects with schizophrenia, 47% of nonparticipants had the paranoid subtype vs 8% of participants. There was also a trend towards longer illness duration in nonparticipants. These results underline the need for neurobiological studies of psychosis to consider sample bias as a confounding variable.

journal_name

Acta Psychiatr Scand

authors

Keks NA,Copolov DL,Mackie B,Stuart GW,Singh BS,McGorry PD,Coffey C

doi

10.1111/j.1600-0447.1991.tb05558.x

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

373-6

issue

5

eissn

0001-690X

issn

1600-0447

journal_volume

83

pub_type

杂志文章
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